Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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UniProt Feature |
Begin: |
277 |
Description: |
Cleavage; by BMP1 |
Type: |
site |
End: |
278 |
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•
•
•
•
•
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UniProt Feature |
Begin: |
22 |
Description: |
Removed by BMP1 |
Type: |
propeptide |
End: |
162 |
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•
•
•
•
•
|
UniProt Feature |
Begin: |
3513 |
Description: |
Cleavage; by BMP1 |
Type: |
site |
End: |
3514 |
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Publication |
First Author: |
Rosell-GarcĂa T |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain. |
Volume: |
294 |
Issue: |
29 |
Pages: |
11087-11100 |
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Publication |
First Author: |
Valencia M |
Year: |
2014 |
Journal: |
Am J Med Genet A |
Title: |
Report of a newly indentified patient with mutations in BMP1 and underlying pathogenetic aspects. |
Volume: |
164A |
Issue: |
5 |
Pages: |
1143-50 |
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•
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Allele |
Name: |
bone morphogenetic protein 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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DO Term |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Allele |
Name: |
bone morphogenetic protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Allele |
Name: |
transgene insertion IL335, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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Strain |
Attribute String: |
mutant stock, transgenic |
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Publication |
First Author: |
Li SW |
Year: |
1996 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. |
Volume: |
93 |
Issue: |
10 |
Pages: |
5127-30 |
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•
•
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Publication |
First Author: |
Prockop DJ |
Year: |
1998 |
Journal: |
Matrix Biol |
Title: |
Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling. |
Volume: |
16 |
Issue: |
7 |
Pages: |
399-408 |
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Publication |
First Author: |
Medeck RJ |
Year: |
2003 |
Journal: |
Biochem J |
Title: |
BMP-1-mediated proteolytic processing of alternatively spliced isoforms of collagen type XI. |
Volume: |
376 |
Issue: |
Pt 2 |
Pages: |
361-8 |
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Publication |
First Author: |
Anastasi C |
Year: |
2020 |
Journal: |
Sci Signal |
Title: |
BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1. |
Volume: |
13 |
Issue: |
639 |
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Publication |
First Author: |
Wang J |
Year: |
2021 |
Journal: |
J Periodontol |
Title: |
Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis. |
Volume: |
92 |
Issue: |
7 |
Pages: |
1018-1029 |
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Protein Domain |
Type: |
Family |
Description: |
Bone morphogenetic protein 1 (BMP1) is a member of the astacin family (MEROPS family M12A) of metalloproteinases which plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins []. During ECM formation, this protein is involved in the cleavage of the C-terminal propeptides of procollagen I, II and III and the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers [, , ]. BMP1 participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair[, ]. BMP1 is essential for human type I collagen fibrillogenesis []and induces cartilage and bone formation [, ]. Additional BMP1 substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation []. |
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Publication |
First Author: |
Ge G |
Year: |
2006 |
Journal: |
Birth Defects Res C Embryo Today |
Title: |
Developmental roles of the BMP1/TLD metalloproteinases. |
Volume: |
78 |
Issue: |
1 |
Pages: |
47-68 |
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•
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Publication |
First Author: |
Sarras MP Jr |
Year: |
1996 |
Journal: |
Bioessays |
Title: |
BMP-1 and the astacin family of metalloproteinases: a potential link between the extracellular matrix, growth factors and pattern formation. |
Volume: |
18 |
Issue: |
6 |
Pages: |
439-42 |
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Publication |
First Author: |
Mullins MC |
Year: |
1998 |
Journal: |
Trends Genet |
Title: |
Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs. |
Volume: |
14 |
Issue: |
4 |
Pages: |
127-9 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry includes the zinc-dependent metalloprotease domain of BMP1 and tolloid-like proteins. Procollagen C-peptidase (BMP1, Bone morphogenetic protein 1; MEROPS identifier M12.005) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The Drosophila protein tolloid (MEROPS identifier M12.010) and its Xenopus homologue xolloid (MEROPS identifier M12.015) cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning[, , ]. |
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Publication |
First Author: |
Ng D |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. |
Volume: |
7 |
Issue: |
2 |
Pages: |
e41 |
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Publication |
First Author: |
Zhu Q |
Year: |
2012 |
Journal: |
Connect Tissue Res |
Title: |
Partial blocking of mouse DSPP processing by substitution of Gly(451)-Asp(452) bond suggests the presence of secondary cleavage site(s). |
Volume: |
53 |
Issue: |
4 |
Pages: |
307-12 |
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Publication |
First Author: |
Borazjani A |
Year: |
2019 |
Journal: |
Biol Reprod |
Title: |
Role of lysyl oxidase like 1 in regulation of postpartum connective tissue metabolism in the mouse vagina†. |
Volume: |
101 |
Issue: |
5 |
Pages: |
916-927 |
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•
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•
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Publication |
First Author: |
He W |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. |
Volume: |
107 |
Issue: |
49 |
Pages: |
21110-5 |
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Publication |
First Author: |
Harlow CR |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Targeting lysyl oxidase reduces peritoneal fibrosis. |
Volume: |
12 |
Issue: |
8 |
Pages: |
e0183013 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
775
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
991
|
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
511
|
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1013
|
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1012
|
Fragment?: |
false |
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•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1013
|
Fragment?: |
false |
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•
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Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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