Ring Finger Protein 14 (RNF14, ARA54, Triad2) belongs to the ring between ring fingers (RBR) family []. It is an E3 ubiquitin ligase that acts on unknown substrates and has autoubiquitination activity []. It is an enhancer of the Wnt-dependent transcriptional outputs acting at the level of the TCF/LEF-beta-catenin complex [, ]. It may function as an AR (androgen receptor) coactivators to induce AR target gene expression []. RNF14 may play a regulatory role in mitochondrial and immune gene expression [].
