Type |
Details |
Score |
Protein Domain |
Type: |
Family |
Description: |
The band-7 protein family comprises a diverse set of membrane-bound proteins characterised by the presence of a conserved domain, the band-7 domain, also known as SPFH or PHB domain. The exact function of the band-7 domain is not known, but examples from animal and bacterial stomatin-type proteins demonstrate binding to lipids and the ability to assemble into membrane-bound oligomers that form putative scaffolds [].A variety of proteins belong to the band-7 family. These include the stomatins, prohibitins, flottins and the HflK/C bacterial proteins. Eukaryotic band 7 proteins tend to be oligomeric and are involved in membrane-associated processes. Stomatins are involved in ion channel function, prohibitins are involved in modulating the activity of a membrane-bound FtsH protease and the assembly of mitochondrial respiratory complexes, and flotillins are involved in signal transduction and vesicle trafficking [].Stomatin, also known as human erythrocyte membrane protein band 7.2b [], was first identified in the band 7 region of human erythrocyte membrane proteins. It is an oligomeric, monotopic membrane protein associated with cholesterol-rich membranes/lipid rafts. Human stomatin is ubiquitously expressed in all tissues; highly in hematopoietic cells, relatively low in brain. It is associated with the plasma membrane and cytoplasmic vesicles of fibroblasts, epithelial and endothelial cells [].Stomatin is believed to be involved in regulating monovalent cation transport through lipid membranes. Absence of the protein in hereditary stomatocytosis is believed to be the reason for the leakage of Na+and K+ions into and from erythrocytes []. Stomatin is also expressed in mechanosensory neurons, where it may interact directly with transduction components, including cation channels [].Stomatin proteins have been identified in various organisms, including Caenorhabditis elegans. There are nine stomatin-like proteins in C. elegans, MEC-2 being the one best characterised []. In mammals, other stomatin family members are stomatin-like proteins SLP1, SLP2 and SLP3, and NPHS2 (podocin), which display selective expression patterns []. Stomatin family members are oligomeric, they mostly localise to membrane domains, and in many cases have been shown to modulate ion channel activity.The stomatins and prohibitins, and to a lesser extent flotillins, are highly conserved protein families and are found in a variety of organisms ranging from prokaryotes to higher eukaryotes, whereas HflK and HflC homologues are only present in bacteria [].This entry matches Stomatin, HflK and HflC proteins. |
|
•
•
•
•
•
|
Publication |
First Author: |
Price MP |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Stomatin modulates gating of acid-sensing ion channels. |
Volume: |
279 |
Issue: |
51 |
Pages: |
53886-91 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
385
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
385
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
265
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gehl B |
Year: |
2014 |
Journal: |
Front Plant Sci |
Title: |
Mitochondrial Band-7 family proteins: scaffolds for respiratory chain assembly? |
Volume: |
5 |
|
Pages: |
141 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goldstein BJ |
Year: |
2003 |
Journal: |
J Assoc Res Otolaryngol |
Title: |
Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons. |
Volume: |
4 |
Issue: |
1 |
Pages: |
74-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lapatsina L |
Year: |
2012 |
Journal: |
Eur J Cell Biol |
Title: |
Stomatin-domain proteins. |
Volume: |
91 |
Issue: |
4 |
Pages: |
240-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rungaldier S |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Structure-function analysis of human stomatin: A mutation study. |
Volume: |
12 |
Issue: |
6 |
Pages: |
e0178646 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boehm M |
Year: |
2009 |
Journal: |
J Bacteriol |
Title: |
Structural and mutational analysis of band 7 proteins in the cyanobacterium Synechocystis sp. strain PCC 6803. |
Volume: |
191 |
Issue: |
20 |
Pages: |
6425-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Christov M |
Year: |
2018 |
Journal: |
JCI Insight |
Title: |
Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. |
Volume: |
3 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Frahsek M |
Year: |
2019 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Cre recombinase toxicity in podocytes: a novel genetic model for FSGS in adolescent mice. |
Volume: |
317 |
Issue: |
5 |
Pages: |
F1375-F1382 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rogg M |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton. |
Volume: |
7 |
Issue: |
1 |
Pages: |
15910 |
|
•
•
•
•
•
|
Publication |
First Author: |
Soda K |
Year: |
2012 |
Journal: |
J Clin Invest |
Title: |
Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. |
Volume: |
122 |
Issue: |
12 |
Pages: |
4401-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhong Y |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes. |
Volume: |
10 |
Issue: |
1 |
Pages: |
4523 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sachs N |
Year: |
2012 |
Journal: |
J Clin Invest |
Title: |
Blood pressure influences end-stage renal disease of Cd151 knockout mice. |
Volume: |
122 |
Issue: |
1 |
Pages: |
348-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pedigo CE |
Year: |
2016 |
Journal: |
J Clin Invest |
Title: |
Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury. |
Volume: |
126 |
Issue: |
9 |
Pages: |
3336-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schiffer M |
Year: |
2015 |
Journal: |
Nat Med |
Title: |
Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. |
Volume: |
21 |
Issue: |
6 |
Pages: |
601-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gödel M |
Year: |
2011 |
Journal: |
J Clin Invest |
Title: |
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. |
Volume: |
121 |
Issue: |
6 |
Pages: |
2197-209 |
|
•
•
•
•
•
|
Publication |
First Author: |
An YA |
Year: |
2023 |
Journal: |
Mol Metab |
Title: |
Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model. |
Volume: |
69 |
|
Pages: |
101680 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verissimo T |
Year: |
2023 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells. |
Volume: |
324 |
Issue: |
6 |
Pages: |
F532-F543 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujita Y |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
An adjustment in BMP4 function represents a treatment for diabetic nephropathy and podocyte injury. |
Volume: |
8 |
Issue: |
1 |
Pages: |
13011 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu F |
Year: |
2010 |
Journal: |
J Am Soc Nephrol |
Title: |
Anion exchanger 1 interacts with nephrin in podocytes. |
Volume: |
21 |
Issue: |
9 |
Pages: |
1456-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hartleben B |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Role of the polarity protein Scribble for podocyte differentiation and maintenance. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e36705 |
|
•
•
•
•
•
|
Publication |
First Author: |
Madhusudhan T |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy. |
Volume: |
6 |
|
Pages: |
6496 |
|
•
•
•
•
•
|
Publication |
First Author: |
Madhusudhan T |
Year: |
2017 |
Journal: |
Blood |
Title: |
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function. |
Volume: |
130 |
Issue: |
12 |
Pages: |
1445-1455 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rayes J |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
The podoplanin-CLEC-2 axis inhibits inflammation in sepsis. |
Volume: |
8 |
Issue: |
1 |
Pages: |
2239 |
|
•
•
•
•
•
|
Publication |
First Author: |
Canaud G |
Year: |
2013 |
Journal: |
Nat Med |
Title: |
AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. |
Volume: |
19 |
Issue: |
10 |
Pages: |
1288-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ducasa GM |
Year: |
2019 |
Journal: |
J Clin Invest |
Title: |
ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes. |
Volume: |
129 |
Issue: |
8 |
Pages: |
3387-3400 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harvey SJ |
Year: |
2007 |
Journal: |
Am J Pathol |
Title: |
Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity. |
Volume: |
171 |
Issue: |
1 |
Pages: |
139-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zimmerman SE |
Year: |
2018 |
Journal: |
J Am Soc Nephrol |
Title: |
Nephronectin Regulates Mesangial Cell Adhesion and Behavior in Glomeruli. |
Volume: |
29 |
Issue: |
4 |
Pages: |
1128-1140 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hartleben B |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. |
Volume: |
120 |
Issue: |
4 |
Pages: |
1084-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tagawa A |
Year: |
2016 |
Journal: |
Diabetes |
Title: |
Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy. |
Volume: |
65 |
Issue: |
3 |
Pages: |
755-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2020 |
Journal: |
EMBO Rep |
Title: |
Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS. |
Volume: |
21 |
Issue: |
2 |
Pages: |
e48781 |
|
•
•
•
•
•
|
Publication |
First Author: |
Höhne M |
Year: |
2013 |
Journal: |
Am J Pathol |
Title: |
Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions. |
Volume: |
182 |
Issue: |
2 |
Pages: |
332-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ren J |
Year: |
2022 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage. |
Volume: |
322 |
Issue: |
2 |
Pages: |
F164-F174 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rogg M |
Year: |
2021 |
Journal: |
J Am Soc Nephrol |
Title: |
SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance. |
Volume: |
32 |
Issue: |
3 |
Pages: |
563-579 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brukamp K |
Year: |
2007 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease. |
Volume: |
293 |
Issue: |
4 |
Pages: |
F1397-407 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schell C |
Year: |
2013 |
Journal: |
J Am Soc Nephrol |
Title: |
N-wasp is required for stabilization of podocyte foot processes. |
Volume: |
24 |
Issue: |
5 |
Pages: |
713-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brinkkoetter PT |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. |
Volume: |
27 |
Issue: |
5 |
Pages: |
1551-1566.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Payne H |
Year: |
2017 |
Journal: |
Blood |
Title: |
Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis. |
Volume: |
129 |
Issue: |
14 |
Pages: |
2013-2020 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steenhard BM |
Year: |
2010 |
Journal: |
Am J Pathol |
Title: |
Deletion of von Hippel-Lindau in glomerular podocytes results in glomerular basement membrane thickening, ectopic subepithelial deposition of collagen {alpha}1{alpha}2{alpha}1(IV), expression of neuroglobin, and proteinuria. |
Volume: |
177 |
Issue: |
1 |
Pages: |
84-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Potla U |
Year: |
2014 |
Journal: |
J Clin Invest |
Title: |
Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. |
Volume: |
124 |
Issue: |
4 |
Pages: |
1757-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bechtel W |
Year: |
2013 |
Journal: |
J Am Soc Nephrol |
Title: |
Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis. |
Volume: |
24 |
Issue: |
5 |
Pages: |
727-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Faria D |
Year: |
2014 |
Journal: |
Kidney Int |
Title: |
The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. |
Volume: |
85 |
Issue: |
6 |
Pages: |
1369-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henique C |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. |
Volume: |
8 |
Issue: |
1 |
Pages: |
1829 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pace JA |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney. |
Volume: |
7 |
Issue: |
36 |
Pages: |
eabg6600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eremina V |
Year: |
2008 |
Journal: |
N Engl J Med |
Title: |
VEGF inhibition and renal thrombotic microangiopathy. |
Volume: |
358 |
Issue: |
11 |
Pages: |
1129-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu H |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
Rac1 activation in podocytes induces rapid foot process effacement and proteinuria. |
Volume: |
33 |
Issue: |
23 |
Pages: |
4755-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Badal SS |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy. |
Volume: |
7 |
|
Pages: |
12076 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song K |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney. |
Volume: |
292 |
Issue: |
40 |
Pages: |
16491-16497 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2012 |
Journal: |
Cell Metab |
Title: |
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. |
Volume: |
15 |
Issue: |
2 |
Pages: |
186-200 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(NPHS2-rtTA2*M2)1Jbk/Tg(NPHS2-rtTA2*M2)1Jbk Tg(tetO-cre)LC1Bjd/Tg(tetO-cre)LC1Bjd |
Background: |
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(NPHS2-rtTA2*M2)1Jbk/Tg(NPHS2-rtTA2*M2)1Jbk Tg(tetO-cre)LC1Bjd/? |
Background: |
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
212
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
286
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
287
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
287
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
399
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
197
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
399
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
399
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
287
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Stewart GW |
Year: |
1997 |
Journal: |
Int J Biochem Cell Biol |
Title: |
Stomatin. |
Volume: |
29 |
Issue: |
2 |
Pages: |
271-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng M |
Year: |
2008 |
Journal: |
PLoS Genet |
Title: |
Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e1000061 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang L |
Year: |
2017 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. |
Volume: |
313 |
Issue: |
2 |
Pages: |
F430-F439 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jarad G |
Year: |
2011 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Dystroglycan does not contribute significantly to kidney development or function, in health or after injury. |
Volume: |
300 |
Issue: |
3 |
Pages: |
F811-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smeets B |
Year: |
2011 |
Journal: |
J Am Soc Nephrol |
Title: |
Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis. |
Volume: |
22 |
Issue: |
7 |
Pages: |
1262-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu J |
Year: |
2016 |
Journal: |
J Am Soc Nephrol |
Title: |
Comparison of Glomerular and Podocyte mRNA Profiles in Streptozotocin-Induced Diabetes. |
Volume: |
27 |
Issue: |
4 |
Pages: |
1006-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pitera JE |
Year: |
2012 |
Journal: |
Genesis |
Title: |
Generation of mice with a conditional null Fraser syndrome 1 (Fras1) allele. |
Volume: |
50 |
Issue: |
12 |
Pages: |
892-8 |
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Publication |
First Author: |
Hurcombe JA |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function. |
Volume: |
10 |
Issue: |
1 |
Pages: |
403 |
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Publication |
First Author: |
Cao A |
Year: |
2021 |
Journal: |
J Clin Invest |
Title: |
DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity. |
Volume: |
131 |
Issue: |
10 |
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Publication |
First Author: |
Goldberg S |
Year: |
2010 |
Journal: |
J Am Soc Nephrol |
Title: |
Maintenance of glomerular filtration barrier integrity requires laminin alpha5. |
Volume: |
21 |
Issue: |
4 |
Pages: |
579-86 |
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•
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Publication |
First Author: |
Widmeier E |
Year: |
2019 |
Journal: |
J Am Soc Nephrol |
Title: |
Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice. |
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Publication |
First Author: |
Li SY |
Year: |
2019 |
Journal: |
J Am Soc Nephrol |
Title: |
DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development. |
Volume: |
30 |
Issue: |
4 |
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594-609 |
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Publication |
First Author: |
Koehler S |
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2022 |
Journal: |
Kidney Int |
Title: |
Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier. |
Volume: |
101 |
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4 |
Pages: |
733-751 |
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Publication |
First Author: |
Bollée G |
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2011 |
Journal: |
Nat Med |
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Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. |
Volume: |
17 |
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10 |
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Publication |
First Author: |
Mitrofanova A |
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2019 |
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Nat Commun |
Title: |
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease. |
Volume: |
10 |
Issue: |
1 |
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2692 |
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Publication |
First Author: |
Tian X |
Year: |
2023 |
Journal: |
J Clin Invest |
Title: |
Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases. |
Volume: |
133 |
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24 |
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Publication |
First Author: |
Macé C |
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2020 |
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Kidney Int |
Title: |
The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases. |
Volume: |
97 |
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4 |
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753-764 |
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Publication |
First Author: |
Hathaway CK |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice. |
Volume: |
112 |
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18 |
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5815-20 |
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Publication |
First Author: |
Medina Rangel PX |
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2023 |
Journal: |
J Am Soc Nephrol |
Title: |
Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2. |
Volume: |
34 |
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3 |
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433-450 |
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Publication |
First Author: |
Oliva Trejo JA |
Year: |
2014 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. |
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446 |
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4 |
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1190-6 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
282
|
Fragment?: |
false |
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•
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•
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Publication |
First Author: |
Albert GI |
Year: |
2015 |
Journal: |
J Mol Cell Biol |
Title: |
The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function. |
Volume: |
7 |
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5 |
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402-14 |
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Publication |
First Author: |
Nelson T |
Year: |
2019 |
Journal: |
J Am Soc Nephrol |
Title: |
Early B Cell Factor 1 (EBF1) Regulates Glomerular Development by Controlling Mesangial Maturation and Consequently COX-2 Expression. |
Volume: |
30 |
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9 |
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1559-1572 |
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Publication |
First Author: |
Widmeier E |
Year: |
2020 |
Journal: |
J Am Soc Nephrol |
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ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment. |
Volume: |
31 |
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6 |
Pages: |
1191-1211 |
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Publication |
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Aypek H |
Year: |
2022 |
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J Clin Invest |
Title: |
Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy. |
Volume: |
132 |
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9 |
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Publication |
First Author: |
Chan TD |
Year: |
2012 |
Journal: |
Immunity |
Title: |
Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen. |
Volume: |
37 |
Issue: |
5 |
Pages: |
893-904 |
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Publication |
First Author: |
Hackl MJ |
Year: |
2013 |
Journal: |
Nat Med |
Title: |
Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. |
Volume: |
19 |
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12 |
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1661-6 |
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Publication |
First Author: |
Bork T |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk. |
Volume: |
23 |
Issue: |
7 |
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Publication |
First Author: |
Chuang PY |
Year: |
2014 |
Journal: |
Am J Pathol |
Title: |
In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells. |
Volume: |
184 |
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7 |
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Publication |
First Author: |
Zambrano S |
Year: |
2019 |
Journal: |
J Am Soc Nephrol |
Title: |
GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway. |
Volume: |
30 |
Issue: |
9 |
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1573-1586 |
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Publication |
First Author: |
Lenoir O |
Year: |
2015 |
Journal: |
Autophagy |
Title: |
Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. |
Volume: |
11 |
Issue: |
7 |
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1130-45 |
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Publication |
First Author: |
Grahammer F |
Year: |
2016 |
Journal: |
JCI Insight |
Title: |
A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. |
Volume: |
1 |
Issue: |
9 |
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