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Search results 101 to 117 out of 117 for Edem1

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Type Details Score
Publication
24737672 | -
First Author: Hüttner S
Year: 2014
Journal: Plant Cell
Title: Arabidopsis Class I α-Mannosidases MNS4 and MNS5 Are Involved in Endoplasmic Reticulum-Associated Degradation of Misfolded Glycoproteins.
Volume: 26
Issue: 4
Pages: 1712-1728
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Protein Domain
IPR044674 | EDEM1/2/3
Type: Family
Description: This entry represents a group of alpha-1,2-specific exomannosidases that are involved in endoplasmic reticulum-associated degradation (ERAD), including EDEM1/2/3 from humans, Mnl1 from yeasts and MNS4/5 from Arabidopsis. Mnl1 forms a complex with Pdi1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response []. In humans, mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 is performed mainly by EDEM3 and to a lesser extent by EDEM1, while EDEM2 catalyses the first mannose trimming step from Man9GlcNAc2 []. EDEM1 has been shown to recognise and deliver misfolded proteins to the SEL1L-containing ERAD complex []. MNS4/5 function in the formation of unique N-glycan structures that are specifically recognized by components of the endoplasmic reticulum-associated degradation (ERAD) machinery, which leads to the degradation of misfolded glycoproteins [].
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Publication
23650437 | J:198929
First Author: Das I
Year: 2013
Journal: J Exp Med
Title: Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins.
Volume: 210
Issue: 6
Pages: 1201-16
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Publication
25092655 | -
First Author: Ninagawa S
Year: 2014
Journal: J Cell Biol
Title: EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.
Volume: 206
Issue: 3
Pages: 347-56
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Protein
Q2HXL6
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
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Protein
Q925U4
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
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Protein
Q8BJT9
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Protein
B7ZNP0
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q6ZQG3
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: true
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Protein
Q8BYV2
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: true
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Protein
Q8C0J7
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Protein
Q3UX12
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
A0A087WQK5
Organism: Mus musculus/domesticus
Length: 917  
Fragment?: false
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Protein
A0A0N4SV08
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Protein
A0A087WR24
Organism: Mus musculus/domesticus
Length: 947  
Fragment?: false
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Protein
B7ZNN9
Organism: Mus musculus/domesticus
Length: 917  
Fragment?: false
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Protein
Q3U9S2
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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