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Search results 101 to 200 out of 206 for Dsg3

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2694221
Stage: TS21
Assay Id: MGI:5636048
Age: embryonic day 13.5
Specimen Label: 3j
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2694222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5636048
Age: embryonic day 14.5
Specimen Label: 3k
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2694223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5636048
Age: embryonic day 15.5
Note: Expressed in the upper cell layers.
Specimen Label: 3l
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2694220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5636048
Age: embryonic day 12.5
Note: Much lower level expression in dental lamina. A far more superficial location than that of Dsc2.
Specimen Label: 4j
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:2449033
Assay Type: Immunohistochemistry
Annotation Date: 2003-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752825
Pattern: Spotted
Stage: TS25
Assay Id: MGI:2449101
Age: embryonic day 17.5
Image: 1G
Note: Expression was detected in desmosomes.
Specimen Label: 1G
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2449033
Assay Type: Immunohistochemistry
Annotation Date: 2003-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752825
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:2449101
Age: embryonic day 17.5
Image: 1H
Note: Expression was diffusely distributed over the cell membrane and in the cytoplasm.
Specimen Label: 1H
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5767158
Assay Type: Immunohistochemistry
Annotation Date: 2016-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752827
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:5767200
Age: postnatal newborn
Specimen Label: S5C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5767158
Assay Type: Immunohistochemistry
Annotation Date: 2016-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752827
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:5767200
Age: postnatal newborn
Note: Similar expression in basal layer of skin in both wild-type and Perp mutant newborns.
Specimen Label: S5D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5636048
Age: embryonic day 15.5
Note: Restricted to the intervening, suprabasal cell layers.
Specimen Label: 4l
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5636048
Age: embryonic day 15.5
Specimen Label: 2e
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1776321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5636048
Age: embryonic day 13.5
Note: Expressed in the interfollicular epithelium.
Specimen Label: 6j
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1776324
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5636048
Age: embryonic day 16.5
Note: Restricted to the basal layers.
Specimen Label: 6l
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760520
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5636048
Age: embryonic day 12.5
Note: Expressed in the more superficial parts.
Specimen Label: 5j
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760521
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5636048
Age: embryonic day 13.5
Note: Expression is strongly upregulated in the more differentiated inner cell layer cells.
Specimen Label: 5k
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5636048
Age: embryonic day 15.5
Note: Restricted to suprabasal cell layers.
Specimen Label: 5l
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2672021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5636048
Age: embryonic day 13.5
Note: Expression was more prominent over the inner cell layers of the downgrowth.
Specimen Label: 6j
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5636048
Age: embryonic day 14.5
Note: Expression was more strongly over the inner cell layers of the downgrowth. Lower level expression in the presumptive matrix region.
Specimen Label: 6k
Detected: true
Specimen Num: 12
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•
GXD Expression
GXD Expression
 
Probe: MGI:1196530
Assay Type: RNA in situ
Annotation Date: 2015-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2672024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5636048
Age: embryonic day 16.5
Note: Stronger expression over the inner layers of the outer root sheath.
Specimen Label: 6l
Detected: true
Specimen Num: 13
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Publication
8486729 | J:4712
First Author: Buxton RS
Year: 1993
Journal: J Cell Biol
Title: Nomenclature of the desmosomal cadherins.
Volume: 121
Issue: 3
Pages: 481-3
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Publication
12705872 | J:83118
First Author: Kljuic A
Year: 2003
Journal: Cell
Title: Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris.
Volume: 113
Issue: 2
Pages: 249-60
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Publication
12787123 | J:83879
First Author: Whittock NV
Year: 2003
Journal: J Invest Dermatol
Title: Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6.
Volume: 120
Issue: 6
Pages: 970-80
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Publication
11038185 | J:65187
First Author: Koch PJ
Year: 2000
Journal: J Cell Biol
Title: Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein.
Volume: 151
Issue: 2
Pages: 389-400
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Publication
8182278 | J:18223
First Author: Davisson MT
Year: 1994
Journal: J Hered
Title: Balding: a new mutation on mouse chromosome 18 causing hair loss and immunological defects.
Volume: 85
Issue: 2
Pages: 134-6
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Publication
10036185 | J:53316
First Author: Mao NC
Year: 1999
Journal: Genomics
Title: The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2.
Volume: 56
Issue: 1
Pages: 51-8
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Publication
7536656 | J:23776
First Author: Collins JE
Year: 1995
Journal: Development
Title: Regulation of desmocollin transcription in mouse preimplantation embryos.
Volume: 121
Issue: 3
Pages: 743-53
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Publication
7894164 | J:22181
First Author: Ishikawa H
Year: 1994
Journal: Mamm Genome
Title: cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen.
Volume: 5
Issue: 12
Pages: 803-4
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Publication
8786128 | J:33935
First Author: Griffith AJ
Year: 1996
Journal: Genomics
Title: Localization of the homolog of a mouse craniofacial mutant to human chromosome 18q11 and evaluation of linkage to human CLP and CPO.
Volume: 34
Issue: 3
Pages: 299-303
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Publication
36272714 | J:330612
 
First Author: Zheng X
Year: 2022
Journal: Bone
Title: Effects of Fam83h truncation mutation on enamel developmental defects in male C57/BL6J mice.
Volume: 166
Pages: 116595
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Publication
8662222 | J:33557
First Author: Griffith AJ
Year: 1996
Journal: Mamm Genome
Title: Location of the 9257 and ataxia mutations on mouse chromosome 18.
Volume: 7
Issue: 6
Pages: 417-9
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Publication
9837810 | J:51856
First Author: Semb H
Year: 1998
Journal: Am J Hum Genet
Title: The tumor-suppressor function of E-cadherin.
Volume: 63
Issue: 6
Pages: 1588-93
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Publication
12724416 | J:83058
First Author: Ciani L
Year: 2003
Journal: Mol Cell Biol
Title: Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.
Volume: 23
Issue: 10
Pages: 3575-82
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Publication
21844209 | J:176963
First Author: Sumigray KD
Year: 2011
Journal: J Cell Biol
Title: Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.
Volume: 194
Issue: 4
Pages: 631-42
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Publication
15797384 | J:97304
First Author: Ihrie RA
Year: 2005
Journal: Cell
Title: Perp is a p63-regulated gene essential for epithelial integrity.
Volume: 120
Issue: 6
Pages: 843-56
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Publication
16418220 | J:105239
First Author: Den Z
Year: 2006
Journal: J Cell Sci
Title: Desmocollin 3 is required for pre-implantation development of the mouse embryo.
Volume: 119
Issue: Pt 3
Pages: 482-9
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Publication
7738386 | J:25255
First Author: Hogan ME
Year: 1995
Journal: J Invest Dermatol
Title: Defects of pelage hairs in 20 mouse mutations.
Volume: 104
Issue: 5 Suppl
Pages: 31S-32S
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Publication
18692037 | J:142136
First Author: Owens P
Year: 2008
Journal: Dev Biol
Title: Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity.
Volume: 322
Issue: 1
Pages: 156-66
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Publication
11781569 | J:73084
First Author: Vasioukhin V
Year: 2001
Journal: Nat Cell Biol
Title: Desmoplakin is essential in epidermal sheet formation.
Volume: 3
Issue: 12
Pages: 1076-85
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Publication
9847250 | J:51129
First Author: Bierkamp C
Year: 1999
Journal: Development
Title: Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.
Volume: 126
Issue: 2
Pages: 371-81
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Publication
23108156 | J:191121
First Author: Ferone G
Year: 2013
Journal: Hum Mol Genet
Title: p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome.
Volume: 22
Issue: 3
Pages: 531-43
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Publication
30689641 | J:272423
First Author: Choi YJ
Year: 2019
Journal: PLoS Genet
Title: RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.
Volume: 15
Issue: 1
Pages: e1007914
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Publication
30923192 | J:277726
 
First Author: Lecland N
Year: 2019
Journal: Life Sci Alliance
Title: Epidermal development requires ninein for spindle orientation and cortical microtubule organization.
Volume: 2
Issue: 2
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Publication
29981310 | J:264609
First Author: Li J
Year: 2018
Journal: Dev Biol
Title: Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.
Volume: 441
Issue: 1
Pages: 191-203
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Publication
34905516 | J:320249
 
First Author: Godsel LM
Year: 2022
Journal: J Clin Invest
Title: Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor.
Volume: 132
Issue: 3
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Publication
- | J:30359
       
First Author: Sundberg JP (ed.)
Year: 1994
Title: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools
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Publication
28973166 | J:253459
First Author: Inoue SI
Year: 2017
Journal: Hum Mol Genet
Title: Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.
Volume: 26
Issue: 23
Pages: 4715-4727
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Allele
Dsg3<em1Smoc> | MGI:7289404
Name: desmoglein 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Dsg3<tm1Stan> | MGI:1857388
Name: desmoglein 3; targeted mutation 1, John R Stanley
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Dsg3<tm1.1(DSG3)Geno> | MGI:7366904
Name: desmoglein 3; targeted mutation 1.1, Genoway
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Publication
12138195 | J:78071
First Author: Merritt AJ
Year: 2002
Journal: Mol Cell Biol
Title: Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation.
Volume: 22
Issue: 16
Pages: 5846-58
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Strain
MGI:2164085 | B6;129X1-Dsg3<tm1Stan>/J
Attribute String: targeted mutation, mutant stock
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Strain
MGI:6144852 | 129S6-Dsg3<tm1Stan>/Rbrc
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Dsg3/Dsg3
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Allele
Tg(KRT1-DSG3)1Dga | MGI:2384724
Name: transgene insertion 1, David R Garrod
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
12631243 | J:82819
First Author: Kljuic A
Year: 2003
Journal: Exp Dermatol
Title: A novel mouse desmosomal cadherin family member, desmoglein 1 gamma.
Volume: 12
Issue: 1
Pages: 20-9
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Publication
23657501 | J:205085
First Author: Mao X
Year: 2014
Journal: J Invest Dermatol
Title: MAPKAP kinase 2 (MK2)-dependent and -independent models of blister formation in pemphigus vulgaris.
Volume: 134
Issue: 1
Pages: 68-76
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Publication
32169475 | J:297220
First Author: Gouin O
Year: 2020
Journal: J Invest Dermatol
Title: Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature.
Volume: 140
Issue: 6
Pages: 1184-1194
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Publication
34848535 | J:318031
 
First Author: Iriki H
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus.
Volume: 118
Issue: 49
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Publication
29535737 | J:319278
 
First Author: Lotti R
Year: 2018
Journal: Front Immunol
Title: Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus.
Volume: 9
Pages: 370
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Publication
25252957 | J:340711
First Author: Eming R
Year: 2014
Journal: J Immunol
Title: Pathogenic IgG antibodies against desmoglein 3 in pemphigus vulgaris are regulated by HLA-DRB1*04:02-restricted T cells.
Volume: 193
Issue: 9
Pages: 4391-9
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Publication
27338829 | J:244537
First Author: Ebert LM
Year: 2016
Journal: Angiogenesis
Title: A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis.
Volume: 19
Issue: 4
Pages: 463-86
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Publication
8143788 | J:17484
First Author: Schäfer S
Year: 1994
Journal: Exp Cell Res
Title: Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins.
Volume: 211
Issue: 2
Pages: 391-9
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Publication
2390969 | -
First Author: Liaw CW
Year: 1990
Journal: EMBO J
Title: Identification and cloning of two species of cadherins in bovine endothelial cells.
Volume: 9
Issue: 9
Pages: 2701-8
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Publication
2384753 | -
First Author: Walsh FS
Year: 1990
Journal: J Neurochem
Title: N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene.
Volume: 55
Issue: 3
Pages: 805-12
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Publication
9443898 | -
 
First Author: Marcozzi C
Year: 1998
Journal: J Cell Sci
Title: Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion.
Volume: 111 ( Pt 4)
Pages: 495-509
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Publication
12582396 | -
First Author: Amagai M
Year: 2003
Journal: J Am Acad Dermatol
Title: Desmoglein as a target in autoimmunity and infection.
Volume: 48
Issue: 2
Pages: 244-52
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Protein Domain
IPR009122 | Desmosomal_cadherin
Type: Family
Description: Cadherins, first discovered in mouse teratocarcinoma cells [], are structurally and functionally similar molecules []that take part in selective calcium-dependent adhesion interactions between cell surfaces []. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro, while those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers, suggesting they may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions, and in the control of intercellular spacing.Structurally, cadherins comprise a number of domains: these include a signal sequence; a propeptide of ~130 residues; an extracellular domain of ~600 residues; a single transmembrane (TM) domain; and a well-conserved C-terminal cytoplasmic domain of ~150 residues. The extracellular domain can be subdivided into 5 parts, 4 of which are repeats of ~110 residues, and the fifth contains 4 conserved cysteines. The calcium-binding region of cadherins is thought to be located in the extracellular domain.Desmosomes are localised junctions that hold cells tightly together, common in tissues subject to mechanical strain (e.g., epithelia). Desmosomal cadherins are TM protein components of desmosomes (for review, see [, , ]), whose extracellular cadherin repeats are responsible for adhesion and whose intracellular regions interact with intermediate filaments via desmosomal plaque proteins plakoglobin, plakobilin and desmoplakin. They are believed to play a wider role in regulation of epithelial differentiation. Two sub-families of desmosomal cadherin have been identified, desmocollin (DSC) and desmoglein (DSG).For each subfamily, three subtypes have been identified, expressed in a cell-type and differentiation-specific manner. Studies in normally desmosome-free cells have shown that expression of at least one DSC and one DSG in combination with plakoglobin is required to promote adhesion []. Little is known about functional differences between the DSG or DSC sub-families. In sequence, however, DSG differs from DSC in having a longer cytoplasmic region containing DSG repeats. Desmogleins have been implicated in autoimmune blistering skin lesion diseases. DSG1 has been shown to be a target antigen in pemphigus foliaceous, and DSG3 in pemphigus vulgaris []. DSG1 is also the target of the Staphylococcus aureus blister-causing toxin A. Mutations in DSG1 resulting in reduced levels or extracellularly truncated proteins are the cause of hepatokeratotic bands on palms and soles, a dominant inherited disease termed palmoplantar keratoderma [].
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Protein
Q8BK55
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: true
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Publication
1893866 | -
First Author: Ginsberg D
Year: 1991
Journal: Development
Title: Expression of a novel cadherin (EP-cadherin) in unfertilized eggs and early Xenopus embryos.
Volume: 111
Issue: 2
Pages: 315-25
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Publication
11509257 | -
First Author: Ishii K
Year: 2001
Journal: Curr Biol
Title: Cadherin function: breaking the barrier.
Volume: 11
Issue: 14
Pages: R569-72
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Publication
12126234 | -
First Author: Garrod DR
Year: 2002
Journal: Mol Membr Biol
Title: Desmosomal adhesion: structural basis, molecular mechanism and regulation (Review).
Volume: 19
Issue: 2
Pages: 81-94
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Publication
11171365 | -
First Author: Angst BD
Year: 2001
Journal: J Cell Sci
Title: The cadherin superfamily.
Volume: 114
Issue: Pt 4
Pages: 625-6
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Protein
Q8C5C8
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
Q9CUH7
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: true
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Protein
O35902
Organism: Mus musculus/domesticus
Length: 993  
Fragment?: false
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Protein
P55849
Organism: Mus musculus/domesticus
Length: 886  
Fragment?: false
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Protein
O55111
Organism: Mus musculus/domesticus
Length: 1122  
Fragment?: false
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Protein
P55850
Organism: Mus musculus/domesticus
Length: 896  
Fragment?: false
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Protein
Q7TMD7
Organism: Mus musculus/domesticus
Length: 1041  
Fragment?: false
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Protein
Q7TSF1
Organism: Mus musculus/domesticus
Length: 1060  
Fragment?: false
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Protein
Q7TSF0
Organism: Mus musculus/domesticus
Length: 911  
Fragment?: false
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Protein
Q61495
Organism: Mus musculus/domesticus
Length: 1057  
Fragment?: false
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Protein
P55292
Organism: Mus musculus/domesticus
Length: 902  
Fragment?: false
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