The Ska complex is an essential mitotic component required for accurate cell division in human cells. It is an important kinetochore component involved in the formation of kinetochore-microtubule interactions, and together with the Ndc80 complex couples chromosome movement to microtubule depolymerization []. The complex is composed of three subunits: Ska1, Ska2, and Ska3.Ska3 was the last subunit of the complex identified []. Ska3 accumulates on kinetochores in prometaphase after nuclear envelope breakdown. During mitosis, it is required for the maintenance of chromosome cohesion and may play an important role in silencing the spindle checkpoint [].
