Probable phospholipid-transporting ATPase IH (also known as ATP11A) belongs to the IV subfamily of the P-type ATPases (P4-ATPase) family, whose members transport phospholipids across the membrane. Most P4-ATPases are known to associate with an accessory or beta-subunit known as CDC50 to form a heteromeric complex. ATP11A is ubiquitously expressed and only binds CDC50A as its beta-subunit [, ]. ATP11A is a catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane [, , , , ].
