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Search results 601 to 675 out of 675 for Comt

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Type Details Score
Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Comt<tm2(COMT)Xzho> | MGI:5661843
Name: catechol-O-methyltransferase; targeted mutation 1, Xianjin Zhou
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Allele
Comt<tm1(COMT)Xzho> | MGI:5661839
Name: catechol-O-methyltransferase; targeted mutation 1, Xianjin Zhou
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Publication
28315782 | J:259963
 
First Author: Solís O
Year: 2017
Journal: Neurobiol Dis
Title: Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice.
Volume: 102
Pages: 133-139
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Publication
22872161 | J:323337
 
First Author: Kimoto S
Year: 2012
Journal: Transl Psychiatry
Title: Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome.
Volume: 2
Pages: e146
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Pathway
R-MMU-379397 | Enzymatic degradation of dopamine by COMT
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Publication
34455061 | J:321015
 
First Author: Gass N
Year: 2021
Journal: Neuroimage
Title: Differential resting-state patterns across networks are spatially associated with Comt and Trmt2a gene expression patterns in a mouse model of 22q11.2 deletion.
Volume: 243
Pages: 118520
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Publication
19617637 | J:152368
First Author: Suzuki G
Year: 2009
Journal: Hum Mol Genet
Title: Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice.
Volume: 18
Issue: 20
Pages: 3914-25
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MP Term
MP:0012584 | abnormal catechol O-methyltransferase activity
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MP Term
MP:0012586 | increased catechol O-methyltransferase activity
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Protein
O88587
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
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MP Term
MP:0012588 | increased brain catechol O-methyltransferase activity
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Protein Coding Gene
MGI:3769724 | Tomt
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A1Y9I9
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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GO Term
GO:0016206 | catechol O-methyltransferase activity
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Publication
9605753 | -
First Author: Thompson PA
Year: 1998
Journal: Cancer Res
Title: Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk.
Volume: 58
Issue: 10
Pages: 2107-10
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Publication
8807664 | -
First Author: Lachman HM
Year: 1996
Journal: Pharmacogenetics
Title: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Volume: 6
Issue: 3
Pages: 243-50
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Protein Domain
IPR017128 | Catechol_O-MeTrfase_euk
Type: Family
Description: This entry represents a family of catechol O-methyltransferases found in eukaryotes. Catechol O-methyl transferase (COMT), along with several other enzymes, degrades catecholamines such as dopamine, epinephrine and norepinephrine. It introduces a methyl group, donated by S-adenosyl methionine (SAM) to the catecholamine. It is found in the postsynaptic neurons []. COMT inactivates catecholamines as well as catechol drugs such as L-DOPA. It is possible that the COMT gene is involved in neuropsychiatric conditions in which there are abnormalities in catecholamine neurotransmission, including mood disorders, schizophrenia, obsessive compulsive disorder, alcohol and substance abuse and attention deficit hyperactivity disorder []. An association between the COMT Val158Met polymorphism and aggressive schizophrenia has been established.
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MP Term
MP:0012585 | decreased catechol O-methyltransferase activity
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MP Term
MP:0012587 | decreased brain catechol O-methyltransferase activity
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Allele
Tg(tetO-Comt)1Kndl | MGI:5693612
Name: transgene insertion 1, Eric R Kandel
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Allele
Comt<tm1Mkae> | MGI:4830700
Name: catechol-O-methyltransferase; targeted mutation 1, Mikko Kaenmaki
Allele Type: Targeted
Attribute String: Modified isoform(s)
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Strain
MGI:5693627 | B6.Cg-Tg(tetO-Comt)1Kndl/J
Attribute String: congenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Comt/Comt
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:96915 | Maoa
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q64133
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-Comt)1Kndl/?
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
E-GEOD-20160 | Gene Expression Data from Prefrontal Cortex and Nucleus Accumbens from Inbred Strains of Mice
Series Id: GSE20160
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
28504928 | J:249939
   
First Author: Cunningham CL
Year: 2017
Journal: Elife
Title: The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.
Volume: 6
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Publication
18794526 | J:137493
First Author: Du X
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A catechol-O-methyltransferase that is essential for auditory function in mice and humans.
Volume: 105
Issue: 38
Pages: 14609-14
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Publication
16234811 | J:102517
First Author: Paterlini M
Year: 2005
Journal: Nat Neurosci
Title: Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.
Volume: 8
Issue: 11
Pages: 1586-94
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Publication
1572656 | J:12680
First Author: Grossman MH
Year: 1992
Journal: Genomics
Title: Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1----q11.2.
Volume: 12
Issue: 4
Pages: 822-5
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Publication
23916480 | J:214166
 
First Author: Rodriguez-Arias M
Year: 2013
Journal: Neuropharmacology
Title: CB1 cannabinoid receptor-mediated aggressive behavior.
Volume: 75
Pages: 172-80
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Publication
16566897 | J:129528
First Author: Hill RA
Year: 2007
Journal: Biol Psychiatry
Title: Estrogen deficient male mice develop compulsive behavior.
Volume: 61
Issue: 3
Pages: 359-66
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Publication
17617387 | J:123773
 
First Author: Weimer JM
Year: 2007
Journal: Brain Res
Title: Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis.
Volume: 1162
Pages: 98-112
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Publication
24735585 | J:312072
First Author: Moskovitz J
Year: 2014
Journal: Int J Neuropsychopharmacol
Title: Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity.
Volume: 17
Issue: 10
Pages: 1707-13
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Publication
1347500 | J:3000
First Author: Winqvist R
Year: 1992
Journal: Cytogenet Cell Genet
Title: The human catechol-O-methyltransferase (COMT) gene maps to band q11.2 of chromosome 22 and shows a frequent RFLP with BglI.
Volume: 59
Issue: 4
Pages: 253-7
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Publication
32133633 | J:340342
First Author: Mouri A
Year: 2020
Journal: Br J Pharmacol
Title: Hispidulin attenuates the social withdrawal in isolated disrupted-in-schizophrenia-1 mutant and chronic phencyclidine-treated mice.
Volume: 177
Issue: 14
Pages: 3210-3224
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Publication
11060283 | J:67294
First Author: Sun QA
Year: 2001
Journal: J Biol Chem
Title: Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing.
Volume: 276
Issue: 5
Pages: 3106-14
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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