The serine incorporator/TMS membrane protein (TDE1/TMS) family include SERINC1-5 from mammals and membrane protein Tms1 from budding yeasts. Members in this family contain eleven transmembrane helices. SERINC1-5 function in incorporating serine into membranes and facilitating the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids []. Serinc3 (also known as TDE1) is overexpressed in tumours []. The function of Tms1 is not clear.
Serine incorporator (Serinc) 1-5 constitute a family of carrier proteins that incorporate serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Serinc family members contain 11 transmembrane domains [].This entry represents Serinc1 (also known as TDE1L or TDE2) and Serinc3 (also known as TDE1). Rat Serinc1 co-localises with lipid biosynthetic enzymes in endoplasmic reticulum membranes. Its two functions, serine synthesis and membrane incorporation, are linked to each other [].Serinc3 expression is increased in some tumours [, ].
