This leucine zipper-containing domain is found in apoptosis antagonizing transcription factor (AATF, also known as Che-1) and related proteins. AATF may function as a general inhibitor of the histone deacetylase HDAC1 []. AATF has been shown to inhibit the abberant production of the amyloid beta peptide 1-42 by direct interaction with Par4 []. This interaction occurs via the leucine zipper.
Apoptosis antagonizing transcription factor (AATF, also known as Che-1) is a adaptor that connects transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis []. It contains a leucine zipper-containing domain []. AATF has been shown to inhibit the aberrant production of the amyloid beta peptide 1-42 by direct interaction with Par4; this interaction occurs via the leucine zipper. []. AATF has also been shown to form a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis [].This entry also includes the yeast protein Bfr2, which is a component of the SSU processome and 90S preribosomes [].
This C-terminal domain is found in apoptosis-antagonizing transcription factor (AATF) proteins []. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.
