Type |
Details |
Score |
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8-12 |
Stage: |
28 |
Structure . Name: |
bone marrow |
Notes: |
MPP3 (LSK CD34+ CD135- CD150- CD48+) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8-12 |
Stage: |
28 |
Structure . Name: |
bone marrow |
Notes: |
MPP3 (LSK CD34+ CD135- CD150- CD48+) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Female |
Age: |
postnatal week 8-12 |
Stage: |
28 |
Structure . Name: |
bone marrow |
Notes: |
MPP3 (LSK CD34+ CD135- CD150- CD48+) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
568
|
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion NK183, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Lenaerts A |
Year: |
2022 |
Journal: |
J Exp Med |
Title: |
EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors. |
Volume: |
219 |
Issue: |
11 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Pietras EM |
Year: |
2015 |
Journal: |
Cell Stem Cell |
Title: |
Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions. |
Volume: |
17 |
Issue: |
1 |
Pages: |
35-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dudak A |
Year: |
2011 |
Journal: |
Eur J Cell Biol |
Title: |
Membrane palmitoylated proteins regulate trafficking and processing of nectins. |
Volume: |
90 |
Issue: |
5 |
Pages: |
365-75 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH3 domain of MPP3, which is a scaffolding protein that colocalizes with MPP5 and CRB1 at the subapical region adjacent to adherens junctions and may function in photoreceptor polarity. It interacts with some nectins and regulates their trafficking and processing. Nectins are cell-cell adhesion proteins involved in the establishment apical-basal polarity at cell adhesion sites []. MPP3 belongs to the membrane-associated guanylate kinase (MAGUK) p55 subfamily. The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains []. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Katoh M |
Year: |
2004 |
Journal: |
Int J Mol Med |
Title: |
Identification and characterization of human MPP7 gene and mouse Mpp7 gene in silico. |
Volume: |
13 |
Issue: |
2 |
Pages: |
333-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stöhr H |
Year: |
2001 |
Journal: |
Genomics |
Title: |
Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins. |
Volume: |
74 |
Issue: |
3 |
Pages: |
377-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
te Velthuis AJ |
Year: |
2007 |
Journal: |
BMC Evol Biol |
Title: |
Molecular evolution of the MAGUK family in metazoan genomes. |
Volume: |
7 |
|
Pages: |
129 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|