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Search results 1101 to 1177 out of 1177 for Otx1

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Type Details Score
Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
19893048 | J:155319
First Author: Omodei D
Year: 2009
Journal: Am J Pathol
Title: Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma.
Volume: 175
Issue: 6
Pages: 2609-17
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Allele
Tg(Otx1-cre)1Eag | MGI:3612835
Name: transgene insertion 1, Elizabeth A Grove
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Otx1<tm6(cre/ERT)Asim> | MGI:6468494
Name: orthodenticle homeobox 1; targeted mutation 6, Antonio Simeone
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase
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Protein
Q3TYJ4
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
Q5SS54
Organism: Mus musculus/domesticus
Length: 355  
Fragment?: false
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Strain
MGI:6335496 | STOCK Otx1<tm6(cre/ERT)Asim>/Cnrm
Attribute String: mutant stock, targeted mutation
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GXD Expression
GXD Expression
Probe: MGI:1309322
Assay Type: Immunohistochemistry
Annotation Date: 2004-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3045224
Age: embryonic day 10.5
Image: 1I
Note: Expression is at the midbrain-hindbrain boundary. The authors state that at this stage endogenous Otx1 is also expressed and this antibody does not distinguish between Otx1 and Otx2.
Specimen Label: 1I
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1309322
Assay Type: Immunohistochemistry
Annotation Date: 2004-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3045224
Age: embryonic day 10.5
Image: 1I
Note: The authors state that at this stage endogenous Otx1 is also expressed and this antibody does not distinguish between Otx1 and Otx2.
Specimen Label: 1I
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1309322
Assay Type: Immunohistochemistry
Annotation Date: 2004-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3045224
Age: embryonic day 10.5
Image: 1I
Note: The authors state that at this stage endogenous Otx1 is also expressed and this antibody does not distinguish between Otx1 and Otx2.
Specimen Label: 1I
Detected: true
Specimen Num: 3
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Allele
Otx1<jv> | MGI:1856925
 
Name: orthodenticle homeobox 1; Jackson waltzer
Allele Type: Spontaneous
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Strain
MGI:2162503 | C57BL/6J-Otx1<jv>/GrsrJ
Attribute String: mutant strain, coisogenic, spontaneous mutation
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Allele
Otx1<tm4(cre)Asim> | MGI:2661060
Name: orthodenticle homeobox 1; targeted mutation 4, Antonio Simeone
Allele Type: Targeted
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Otx1/Otx1
Background: C57BL/6J-Otx1/GrsrJ
Zygosity: hm
Has Mutant Allele: true
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Allele
Otx2<tm1(OTX1)Asim> | MGI:2153202
Name: orthodenticle homeobox 2; targeted mutation 1, Antonio Simeone
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Strain
MGI:5498654 | STOCK Otx1<tm4(cre)Asim>/Cnrm
Attribute String: mutant stock, targeted mutation
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Strain
MGI:3691140 | B6.129-Otx1<tm4(cre)Asim>/J
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Otx1<tm3(OTX2)Asim> | MGI:2153200
Name: orthodenticle homeobox 1; targeted mutation 3, Antonio Simeone
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Strain
MGI:5499142 | STOCK Otx2<tm1(OTX1)Asim>/Cnrm
Attribute String: targeted mutation, mutant stock
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Allele
Otx1<tm2(otd)Asim> | MGI:2153199
Name: orthodenticle homeobox 1; targeted mutation 2, Antonio Simeone
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Allele
Otx2<tm7(OTX1)Asim> | MGI:3042842
Name: orthodenticle homeobox 2; targeted mutation 7, Antonio Simeone
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Genotype
Genotype
Symbol: Tg(Otx1-cre)1Eag/? Wnt3a/Wnt3a<+>
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Otx2/Otx2
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: hm
Has Mutant Allele: true
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Publication
7590242 | J:29682
First Author: Matsuo I
Year: 1995
Journal: Genes Dev
Title: Mouse Otx2 functions in the formation and patterning of rostral head.
Volume: 9
Issue: 21
Pages: 2646-58
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Strain
MGI:5498651 | STOCK Otx1<tm2(otd)Asim>/Cnrm
Attribute String: targeted mutation, mutant stock
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Allele
Otx2<tm2(Otx1)Sia> | MGI:2153203
Name: orthodenticle homeobox 2; targeted mutation 2, Shinichi Aizawa
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Genotype
Genotype
Symbol: Otx2/Otx2
Background: involves: 129P2/OlaHsd * C57BL/6 * (C57BL/6 x DBA/2)F1 * DBA/2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Otx1/Otx1
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Otx1/Otx1
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Otx1/Otx1<+> Otx2/Otx2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Otx2/Otx2
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Otx2/Otx2<+>
Background: involves: C57BL/6 * CBA
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Otx1/Otx1 Otx2/Otx2<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Publication
7896134 | J:24067
First Author: Boncinelli E
Year: 1994
Journal: Genetica
Title: Vertebrate homeobox genes.
Volume: 94
Issue: 2-3
Pages: 127-40
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Protein Domain
IPR003025 | Otx_TF
Type: Family
Description: Otx proteins constitute a class of vertebrate homeodomain-containingtranscription factors that have been shown to be essential for anteriorhead formation, including brain morphogenesis. They are orthologous to theproduct of the Drosophila head gap gene, orthodenticle (Otd), and appear toplay similar roles in both, since the developmental abnormalities caused bydisruption of these transcription factors in one, can be recovered bysubstitution of the factor(s) from the other. Such studies have providedstrong evidence that there exists a conserved genetic programme for insectand mammalian brain development, which presumably arose in a more primitivecommon ancestor [, ].Two vertebrate orthodenticle-related transcription factors have beenindentified, Otx1 and Otx2, which have sizes of 355 and 289 residuesrespectively. They contain a bicoid-like homeodomain, which features aconserved lysine residue at position 9 of the DNA recognition helix, whichis thought to confer high-affinity binding to TAATCC/T elements on DNA [].Otd-like transcription factors have also been found in zebrafish and certain lamprey species.
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Genotype
Genotype
Symbol: Otx1/Otx1<+> Otx2/Otx2<+>
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gbx2/Gbx2 Otx2/Otx2
Background: involves: 129 * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Otx1/Otx1 Otx2/Otx2<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR003022 | Otx2_TF
Type: Family
Description: Otx proteins constitute a class of vertebrate homeodomain-containingtranscription factors that have been shown to be essential for anteriorhead formation, including brain morphogenesis. They are orthologous to theproduct of the Drosophila head gap gene, orthodenticle (Otd), and appear toplay similar roles in both, since the developmental abnormalities caused bydisruption of these transcription factors in one, can be recovered bysubstitution of the factor(s) from the other. Such studies have providedstrong evidence that there exists a conserved genetic programme for insectand mammalian brain development, which presumably arose in a more primitivecommon ancestor [, ].Two vertebrate orthodenticle-related transcription factors have been indentified, Otx1 and Otx2, which have sizes of 355 and 289 residuesrespectively. They contain a bicoid-like homeodomain, which features aconserved lysine residue at position 9 of the DNA recognition helix, whichis thought to confer high-affinity binding to TAATCC/T elements on DNA [].Otd-like transcription factors have also been found in zebrafish and certain lamprey species. Mice completely lacking Otx2 (due to targeted gene disruption) die duringearly embryogenesis. Analysis reveals that they lack the neuroectodermthat is destined to become the forebrain, midbrain and rostral hindbrain.They also show major abnormalities in their body plan. Mice that haveartificially-reduced levels of Otx2 develop head abnormalities reminiscentof otocephaly [].
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Protein Domain
IPR013851 | Otx_TF_C
Type: Domain
Description: Otx proteins constitute a class of vertebrate homeodomain-containingtranscription factors that have been shown to be essential for anteriorhead formation, including brain morphogenesis. They are orthologous to theproduct of the Drosophila head gap gene, orthodenticle (Otd), and appear toplay similar roles in both, since the developmental abnormalities caused bydisruption of these transcription factors in one, can be recovered bysubstitution of the factor(s) from the other. Such studies have providedstrong evidence that there exists a conserved genetic programme for insectand mammalian brain development, which presumably arose in a more primitivecommon ancestor [, ].Two vertebrate orthodenticle-related transcription factors have beenindentified, Otx1 and Otx2, which have sizes of 355 and 289 residuesrespectively. They contain a bicoid-like homeodomain, which features aconserved lysine residue at position 9 of the DNA recognition helix, whichis thought to confer high-affinity binding to TAATCC/T elements on DNA [].Otd-like transcription factors have also been found in zebrafish and certain lamprey species. This entry represents a conserved region found in the C-terminal region of these proteins.
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Publication
16600992 | J:109536
First Author: Arnold JS
Year: 2006
Journal: Hum Mol Genet
Title: Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients.
Volume: 15
Issue: 10
Pages: 1629-39
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Publication
15242798 | J:92326
First Author: Burton Q
Year: 2004
Journal: Dev Biol
Title: The role of Pax2 in mouse inner ear development.
Volume: 272
Issue: 1
Pages: 161-75
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Publication
14999075 | J:90129
First Author: Shin DM
Year: 2004
Journal: J Neurosci
Title: Loss of glutamatergic pyramidal neurons in frontal and temporal cortex resulting from attenuation of FGFR1 signaling is associated with spontaneous hyperactivity in mice.
Volume: 24
Issue: 9
Pages: 2247-58
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Publication
16410414 | J:104373
First Author: Yoshida M
Year: 2006
Journal: Development
Title: Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order.
Volume: 133
Issue: 3
Pages: 537-45
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Protein
P80206
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
Q8VD35
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
D3YZ94
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
Q8R0B5
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Publication
11731460 | J:72726
First Author: Acampora D
Year: 2001
Journal: Development
Title: OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation.
Volume: 128
Issue: 23
Pages: 4801-13
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Protein
O54751
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
Q543C9
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
A0A0A0MQN6
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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