Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
64
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the KIX-binding domain bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 thoughbinding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300 []. |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE35593 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan H |
Year: |
2020 |
Journal: |
Cancer Cell |
Title: |
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. |
Volume: |
38 |
Issue: |
3 |
Pages: |
350-365.e7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
672
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
559
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
652
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
652
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
640
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao Y |
Year: |
2022 |
Journal: |
Cell |
Title: |
Mucus sialylation determines intestinal host-commensal homeostasis. |
Volume: |
185 |
Issue: |
7 |
Pages: |
1172-1188.e28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castets P |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. |
Volume: |
17 |
Issue: |
5 |
Pages: |
731-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ucar A |
Year: |
2012 |
Journal: |
Nat Commun |
Title: |
The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. |
Volume: |
3 |
|
Pages: |
1078 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng XL |
Year: |
2017 |
Journal: |
Nucleic Acids Res |
Title: |
MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. |
Volume: |
45 |
Issue: |
15 |
Pages: |
8785-8805 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kong DK |
Year: |
2010 |
Journal: |
Mol Biol Cell |
Title: |
Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. |
Volume: |
21 |
Issue: |
8 |
Pages: |
1335-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Furuyama T |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. |
Volume: |
279 |
Issue: |
33 |
Pages: |
34741-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santos MA |
Year: |
2014 |
Journal: |
Nature |
Title: |
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. |
Volume: |
514 |
Issue: |
7520 |
Pages: |
107-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
John GB |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation. |
Volume: |
331 |
Issue: |
2 |
Pages: |
292-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chacon-Cabrera A |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
MicroRNA expression and protein acetylation pattern in respiratory and limb muscles of Parp-1(-/-) and Parp-2(-/-) mice with lung cancer cachexia. |
Volume: |
1850 |
Issue: |
12 |
Pages: |
2530-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu S |
Year: |
2011 |
Journal: |
Blood |
Title: |
GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells. |
Volume: |
117 |
Issue: |
7 |
Pages: |
2166-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ren Y |
Year: |
2015 |
Journal: |
BMC Biol |
Title: |
Lhx8 regulates primordial follicle activation and postnatal folliculogenesis. |
Volume: |
13 |
|
Pages: |
39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress. |
Volume: |
285 |
Issue: |
26 |
Pages: |
19976-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng Y |
Year: |
2018 |
Journal: |
Diabetes |
Title: |
SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity. |
Volume: |
67 |
Issue: |
4 |
Pages: |
569-580 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rizzo A |
Year: |
2018 |
Journal: |
Cancer Immunol Res |
Title: |
RORγt-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells. |
Volume: |
6 |
Issue: |
9 |
Pages: |
1082-1092 |
|
•
•
•
•
•
|
Publication |
First Author: |
MartÃnez-Moreno M |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
FoxO-dependent regulation of diacylglycerol kinase α gene expression. |
Volume: |
32 |
Issue: |
20 |
Pages: |
4168-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu D |
Year: |
2010 |
Journal: |
Genes Dev |
Title: |
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. |
Volume: |
24 |
Issue: |
15 |
Pages: |
1620-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li N |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart. |
Volume: |
6 |
|
Pages: |
21228 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du X |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. |
Volume: |
192 |
Issue: |
4 |
Pages: |
1525-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spitali P |
Year: |
2013 |
Journal: |
PLoS Curr |
Title: |
Autophagy is Impaired in the Tibialis Anterior of Dystrophin Null Mice. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Puppa MJ |
Year: |
2014 |
Journal: |
FASEB J |
Title: |
Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma-induced cachexia. |
Volume: |
28 |
Issue: |
2 |
Pages: |
998-1009 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao H |
Year: |
2014 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. |
Volume: |
306 |
Issue: |
9 |
Pages: |
L816-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li XN |
Year: |
2009 |
Journal: |
Diabetes |
Title: |
Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. |
Volume: |
58 |
Issue: |
10 |
Pages: |
2246-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiong Z |
Year: |
2020 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice. |
Volume: |
1866 |
Issue: |
8 |
Pages: |
165806 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheung K |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CD31 signals confer immune privilege to the vascular endothelium. |
Volume: |
112 |
Issue: |
43 |
Pages: |
E5815-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoppstädter J |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage. |
Volume: |
34 |
Issue: |
3 |
Pages: |
4684-4701 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nanda V |
Year: |
2018 |
Journal: |
PLoS Genet |
Title: |
Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. |
Volume: |
14 |
Issue: |
11 |
Pages: |
e1007755 |
|
•
•
•
•
•
|
Publication |
First Author: |
González-Soria I |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
SerpinA3K Deficiency Reduces Oxidative Stress in Acute Kidney Injury. |
Volume: |
24 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Choi S |
Year: |
2019 |
Journal: |
Autophagy |
Title: |
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis. |
Volume: |
15 |
Issue: |
6 |
Pages: |
1069-1081 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ching JK |
Year: |
2013 |
Journal: |
Hum Mol Genet |
Title: |
mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy. |
Volume: |
22 |
Issue: |
6 |
Pages: |
1167-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gwag T |
Year: |
2013 |
Journal: |
Arch Biochem Biophys |
Title: |
Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways. |
Volume: |
537 |
Issue: |
1 |
Pages: |
21-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma W |
Year: |
2015 |
Journal: |
Biochem J |
Title: |
FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3. |
Volume: |
466 |
Issue: |
2 |
Pages: |
291-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bulstrode H |
Year: |
2017 |
Journal: |
Genes Dev |
Title: |
Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators. |
Volume: |
31 |
Issue: |
8 |
Pages: |
757-773 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu G |
Year: |
2019 |
Journal: |
Mol Reprod Dev |
Title: |
Primordial follicle activation is affected by the absence of Sohlh1 in mice. |
Volume: |
86 |
Issue: |
1 |
Pages: |
20-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang P |
Year: |
2014 |
Journal: |
Basic Res Cardiol |
Title: |
The alteration of Hippo/YAP signaling in the development of hypertrophic cardiomyopathy. |
Volume: |
109 |
Issue: |
5 |
Pages: |
435 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
505
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
505
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim KA |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. |
Volume: |
7 |
Issue: |
10 |
Pages: |
e47713 |
|
•
•
•
•
•
|
Publication |
First Author: |
Venkatraman A |
Year: |
2013 |
Journal: |
Nature |
Title: |
Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. |
Volume: |
500 |
Issue: |
7462 |
Pages: |
345-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Das A |
Year: |
2022 |
Journal: |
J Cachexia Sarcopenia Muscle |
Title: |
Systemic ablation of vitamin D receptor leads to skeletal muscle glycogen storage disorder in mice. |
Volume: |
13 |
Issue: |
1 |
Pages: |
467-480 |
|
•
•
•
•
•
|