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Search results 201 to 264 out of 264 for Bcl10

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Type Details Score
Publication
25365219 | -
First Author: Torres JM
Year: 2014
Journal: J Clin Invest
Title: Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.
Volume: 124
Issue: 12
Pages: 5239-48
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Publication
15125833 | J:122695
First Author: Sun L
Year: 2004
Journal: Mol Cell
Title: The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.
Volume: 14
Issue: 3
Pages: 289-301
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Publication
11259443 | J:114026
First Author: Wang L
Year: 2001
Journal: J Biol Chem
Title: Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.
Volume: 276
Issue: 24
Pages: 21405-9
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Publication
30022982 | -
 
First Author: Gehring T
Year: 2018
Journal: Front Immunol
Title: BCL10 - Bridging CARDs to Immune Activation.
Volume: 9
Pages: 1539
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Interaction Experiment
Liu Y (2004)
Description: BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2.
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Publication
18625728 | J:140363
First Author: McCully RR
Year: 2008
Journal: Mol Cell Biol
Title: The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.
Volume: 28
Issue: 18
Pages: 5668-86
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Publication
11278692 | -
First Author: Bertin J
Year: 2001
Journal: J Biol Chem
Title: CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
Volume: 276
Issue: 15
Pages: 11877-82
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GO Term
GO:0002096 | polkadots
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Publication
20685844 | -
First Author: Thome M
Year: 2010
Journal: Cold Spring Harb Perspect Biol
Title: Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1.
Volume: 2
Issue: 9
Pages: a003004
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Protein Domain
IPR033238 | BCL10/E10
Type: Family
Description: This entry includes animal B-cell lymphoma/leukemia 10 (BCL10) and Equine herpesvirus protein E10.In lymphoid cells BCL10 plays a critical role in the activation of the transcription factor nuclear factor kappa B (NF-kB) downstream of a variety of immune receptors, including the TCR, B cell receptor, NK-cell receptors, C type family lectin receptors, Ig family receptors and G protein-coupled receptors [, , ]. Activation of NF-kB through receptor-mediated pathways requires BCL10 to form a complex (known as CBM) with the paracaspase MALT1 and with CARD-containing adaptor protein CARMA []. BCL10 is involved in the regulation of apoptosis; a BCL10 gene tanslocation is found in mucosa-associated lymphoid tissue (MALT) lymphomas [, ]. BCL10 is involved in the adaptive and innate immune response [, ]. Equine herpesvirus protein E10 (v-E10) is the viral homologue of the BCL10 protein []. It induces membrane recruitment of cellular BCL10, and this induces TRAF-mediated NF-kappaB activation [].
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DO Term
DOID:0111939 | immunodeficiency 37
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Allele
Bcl10<m1Btlr> | MGI:6199632
Name: B cell leukemia/lymphoma 10; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6199633 | C57BL/6J-Bcl10<m1Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Allele
Bcl10<tm1.1Jrld> | MGI:6358379
Name: B cell leukemia/lymphoma 10; targeted mutation 1.1, Jurgen Ruland
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Bcl10/Bcl10
Background: C57BL/6J-Bcl10
Zygosity: hm
Has Mutant Allele: true
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Protein
Q80VN1
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: false
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Protein Domain
IPR043574 | CARD19
Type: Family
Description: Caspase recruiment domain-containing proteins (CARDs) are death domains (DDs) found associated with caspases []. They are known to be important in the signalling pathways for apoptosis, inflammation, and host-defense mechanisms [].This entry includes the Caspase-recruitment domain-containing protein 19 (CARD19), also known as Bcl10-interacting protein with CARD (BinCARD) which interacts with apoptosis inducer CARD protein Bcl10 through CARD. It inhibits Bcl10-mediated activation of NF-kappa B and to suppress Bcl10 phosphorylation [].
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Publication
26884334 | J:233726
First Author: Jattani RP
Year: 2016
Journal: J Biol Chem
Title: Intramolecular Interactions and Regulation of Cofactor Binding by the Four Repressive Elements in the Caspase Recruitment Domain-containing Protein 11 (CARD11) Inhibitory Domain.
Volume: 291
Issue: 16
Pages: 8338-48
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DO Term
DOID:0081064 | BN2 diffuse large B-cell lymphoma
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Publication
15637807 | -
First Author: Woo HN
Year: 2004
Journal: FEBS Lett
Title: Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein.
Volume: 578
Issue: 3
Pages: 239-44
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Publication
22880103 | -
First Author: Li S
Year: 2012
Journal: PLoS One
Title: Structural insights into the assembly of CARMA1 and BCL10.
Volume: 7
Issue: 8
Pages: e42775
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Publication
19076343 | -
 
First Author: Ruland J
Year: 2008
Journal: Ann N Y Acad Sci
Title: CARD9 signaling in the innate immune response.
Volume: 1143
Pages: 35-44
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Publication
19359218 | -
First Author: Hara H
Year: 2009
Journal: Trends Immunol
Title: CARD9 versus CARMA1 in innate and adaptive immunity.
Volume: 30
Issue: 5
Pages: 234-42
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Publication
17468049 | -
First Author: Thome M
Year: 2007
Journal: Trends Immunol
Title: Post-translational modifications regulate distinct functions of CARMA1 and BCL10.
Volume: 28
Issue: 6
Pages: 281-8
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Protein Domain
IPR042146 | CARD_BinCARD
Type: Domain
Description: This entry represents the CARD domain found in BinCARD, also known as CARD19. BinCARD interacts with apoptosis inducer CARD protein Bcl10 through CARD. It inhibits Bcl10-mediated activation of NF-kappa B and to suppress Bcl10 phosphorylation [].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Protein Domain
IPR042143 | CARD_BCL10
Type: Domain
Description: This entry represents the CARD domain found in B-cell lymphoma/leukemia 10 (BCL10). BCL10 and Malt1 (mucosa-associated lymphoid tissue-lymphoma-translocation gene 1) are the integral components of CBM signalosomes. They associate with CARD9 to form M-CBM (CBM complex in myeloid immune cells) and with CARMA1 to form L-CBM (CBM complex in lymphoid immune cells), to mediate activation of NF-kB and MAPK by ITAM-coupled receptors expressed on immune cells. Both CARMA1 and CARD9 associate with BCL10 via a CARD-CARD interaction [, ].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Protein Domain
IPR042142 | CARD_CARD9
Type: Domain
Description: This entry represents the CARD domain found in CARD9, which is a central regulator of innate immunity and is highly expressed in dendritic cells and macrophages []. Together with BCL10 (B-cell lymphoma 10) and Malt1 (mucosa-associated lymphoid tissue-lymphoma-translocation gene 1), it forms the M-CBM signalosome (the CBM complex in myeloid immune cells), which mediates activation of NF-kB and MAPK by ITAM-coupled receptors expressed on immune cells. CARD9 associates with BCL10 via a CARD-CARD interaction [].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Protein Domain
IPR042141 | CARD_CARD11
Type: Domain
Description: This entry represents the CARD domain found in CARD11, also known as CARMA1. CARMA1, together with BCL10 (B-cell lymphoma 10) and Malt1 (mucosa-associated lymphoid tissue-lymphoma-translocation gene 1), form the L-CBM signalosome (CBM complex in lymphoid immune cells) which mediates activation of NF-kB and MAPK by ITAM-coupled receptors expressed on immune cells. CARMA1 associates with BCL10 via a CARD-CARD interaction [].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Publication
23129749 | -
First Author: Snow AL
Year: 2012
Journal: J Exp Med
Title: Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.
Volume: 209
Issue: 12
Pages: 2247-61
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Publication
23374270 | -
First Author: Stepensky P
Year: 2013
Journal: J Allergy Clin Immunol
Title: Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects.
Volume: 131
Issue: 2
Pages: 477-85.e1
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Protein Domain
IPR033538 | CARD11
Type: Family
Description: The caspase recruitment domain (CARD) is a homotypic protein interaction module that participates in apoptosis signalling. This entry represents CARD11, which is a large multidomain scaffold protein that functions as upstream activator of NF-kappaB signalling []. It forms a CBM complex with BCL10 and MALT1. The CBM complex links AgR (antigen receptor) triggering to NF-kappaB activation []. Its activity is controlled by an Inhibitory Domain (ID) [].Mutations in the CARD11 gene cause B-cell expansion with NFKB and T-cell anergy (BENTA) []and Immunodeficiency 11 (IMD11) [].
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Publication
14576442 | J:86770
First Author: Ruefli-Brasse AA
Year: 2003
Journal: Science
Title: Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase.
Volume: 302
Issue: 5650
Pages: 1581-4
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Publication
24924627 | J:219442
First Author: Zhao Y
Year: 2014
Journal: Biochem Biophys Res Commun
Title: TCR-induced, PKC-θ-mediated NF-κB activation is regulated by a caspase-8-caspase-9-caspase-3 cascade.
Volume: 450
Issue: 1
Pages: 526-31
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Protein
Q9Z0H7
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
Q3THY9
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
B7ZWE5
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Publication
19815501 | J:153751
First Author: Kojo S
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Volume: 106
Issue: 42
Pages: 17847-51
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Publication
32343482 | J:292094
First Author: Van Nuffel E
Year: 2020
Journal: EMBO Rep
Title: MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice.
Volume: 21
Issue: 7
Pages: e49237
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Publication
30279415 | J:267271
First Author: Schlauderer F
Year: 2018
Journal: Nat Commun
Title: Molecular architecture and regulation of BCL10-MALT1 filaments.
Volume: 9
Issue: 1
Pages: 4041
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Publication
23690623 | J:197408
First Author: Park Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex.
Volume: 110
Issue: 23
Pages: 9433-8
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Publication
33419765 | J:304081
First Author: Zhang S
Year: 2021
Journal: J Immunol
Title: Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner.
Volume: 206
Issue: 4
Pages: 839-848
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Publication
35831018 | J:344986
First Author: Cheng L
Year: 2022
Journal: J Immunol
Title: Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells.
Volume: 209
Issue: 3
Pages: 456-464
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Protein
Q9D1I2
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: false
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Protein
B2RV71
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: false
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Publication
25087226 | -
First Author: Turvey SE
Year: 2014
Journal: J Allergy Clin Immunol
Title: The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.
Volume: 134
Issue: 2
Pages: 276-84
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Publication
9175472 | -
First Author: Hofmann K
Year: 1997
Journal: Trends Biochem Sci
Title: The CARD domain: a new apoptotic signalling motif.
Volume: 22
Issue: 5
Pages: 155-6
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Publication
12101092 | -
First Author: Bouchier-Hayes L
Year: 2002
Journal: EMBO Rep
Title: CARD games in apoptosis and immunity.
Volume: 3
Issue: 7
Pages: 616-21
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Publication
12356734 | J:84961
First Author: Pomerantz JL
Year: 2002
Journal: EMBO J
Title: CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex.
Volume: 21
Issue: 19
Pages: 5184-94
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Publication
15070758 | J:292666
First Author: Schmidt-Supprian M
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation.
Volume: 101
Issue: 13
Pages: 4566-71
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Publication
21771792 | J:176611
First Author: Rajasekaran K
Year: 2011
Journal: J Biol Chem
Title: Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production.
Volume: 286
Issue: 36
Pages: 31213-24
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Publication
18718996 | J:142282
First Author: Bhattacharyya S
Year: 2008
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Lipopolysaccharide activates NF-kappaB by TLR4-Bcl10-dependent and independent pathways in colonic epithelial cells.
Volume: 295
Issue: 4
Pages: G784-90
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Publication
32763502 | J:307276
 
First Author: Rios KE
Year: 2020
Journal: Cell Immunol
Title: CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement.
Volume: 356
Pages: 104179
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Publication
12775719 | J:85109
First Author: Stehlik C
Year: 2003
Journal: J Biol Chem
Title: CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways.
Volume: 278
Issue: 34
Pages: 31941-9
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Publication
17287209 | J:121164
First Author: Noels H
Year: 2007
Journal: J Biol Chem
Title: A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions.
Volume: 282
Issue: 14
Pages: 10180-9
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Publication
19124758 | J:143480
First Author: Goodridge HS
Year: 2009
Journal: J Immunol
Title: Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.
Volume: 182
Issue: 2
Pages: 1146-54
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Publication
19118383 | J:146202
First Author: Bidère N
Year: 2009
Journal: Nature
Title: Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
Volume: 458
Issue: 7234
Pages: 92-6
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Publication
19696203 | J:154132
First Author: Li Z
Year: 2009
Journal: Blood
Title: Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma.
Volume: 114
Issue: 19
Pages: 4158-68
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Protein
A2AIV8
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
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Protein
Q8BVX8
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Publication
24958727 | J:216620
First Author: Qiao H
Year: 2014
Journal: J Biol Chem
Title: The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.
Volume: 289
Issue: 32
Pages: 21973-83
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Publication
28052131 | J:245236
First Author: Ginster S
Year: 2017
Journal: PLoS One
Title: Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.
Volume: 12
Issue: 1
Pages: e0169026
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Protein
Q8CIS0
Organism: Mus musculus/domesticus
Length: 1159  
Fragment?: false
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Publication
17201679 | -
 
First Author: Park HH
Year: 2007
Journal: Annu Rev Immunol
Title: The death domain superfamily in intracellular signaling of apoptosis and inflammation.
Volume: 25
Pages: 561-86
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Protein Coding Gene
MGI:2445027 | Malt1
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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