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Search results 1 to 100 out of 138 for Pcsk2

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Type Details Score
Publication
12191492 | J:77569
First Author: Mbikay M
Year: 2002
Journal: Brain Res Mol Brain Res
Title: Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene.
Volume: 102
Issue: 1-2
Pages: 35-47
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Publication
27999871 | J:240112
First Author: Courtade JA
Year: 2017
Journal: Diabetologia
Title: Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide.
Volume: 60
Issue: 3
Pages: 453-463
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Publication
9192619 | J:41505
First Author: Furuta M
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.
Volume: 94
Issue: 13
Pages: 6646-51
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Publication
12860111 | J:119037
First Author: Miller R
Year: 2003
Journal: Neuropeptides
Title: Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice.
Volume: 37
Issue: 3
Pages: 140-8
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Publication
19968759 | J:159031
First Author: Zhang X
Year: 2010
Journal: J Neurochem
Title: Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis.
Volume: 112
Issue: 5
Pages: 1168-79
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Publication
24456331 | J:236905
First Author: Jones HB
Year: 2014
Journal: Int J Exp Pathol
Title: Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis.
Volume: 95
Issue: 1
Pages: 29-48
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Publication
10987860 | J:126657
First Author: Berman Y
Year: 2000
Journal: J Neurochem
Title: Defective prodynorphin processing in mice lacking prohormone convertase PC2.
Volume: 75
Issue: 4
Pages: 1763-70
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Publication
16905251 | J:112641
First Author: Croissandeau G
Year: 2006
Journal: Neurosci Lett
Title: Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.
Volume: 406
Issue: 1-2
Pages: 71-5
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Publication
25070661 | J:316742
First Author: Yuan R
Year: 2015
Journal: J Gerontol A Biol Sci Med Sci
Title: Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1.
Volume: 70
Issue: 7
Pages: 817-26
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Publication
20185691 | J:159247
First Author: Fujita Y
Year: 2010
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut.
Volume: 298
Issue: 5
Pages: G608-14
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Publication
11812747 | J:74302
First Author: Webb GC
Year: 2002
Journal: Diabetes
Title: Glucagon replacement via micro-osmotic pump corrects hypoglycemia and alpha-cell hyperplasia in prohormone convertase 2 knockout mice.
Volume: 51
Issue: 2
Pages: 398-405
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Publication
27208618 | J:235963
 
First Author: Lutfy K
Year: 2016
Journal: Neuroscience
Title: Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence.
Volume: 329
Pages: 318-25
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Publication
10089884 | J:53349
First Author: Westphal CH
Year: 1999
Journal: Cell
Title: The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease.
Volume: 96
Issue: 5
Pages: 689-700
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Publication
11356850 | J:120493
First Author: Furuta M
Year: 2001
Journal: J Biol Chem
Title: Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.
Volume: 276
Issue: 29
Pages: 27197-202
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Publication
2017186 | J:11129
First Author: Seidah NG
Year: 1991
Journal: Mol Endocrinol
Title: Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.
Volume: 5
Issue: 1
Pages: 111-22
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Publication
2169760 | J:10744
First Author: Seidah NG
Year: 1990
Journal: DNA Cell Biol
Title: cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
Volume: 9
Issue: 6
Pages: 415-24
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Publication
14576186 | J:88673
First Author: Laurent V
Year: 2004
Journal: Endocrinology
Title: Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice.
Volume: 145
Issue: 2
Pages: 519-28
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Publication
15878971 | J:129821
First Author: Peinado JR
Year: 2005
Journal: Endocrinology
Title: Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes.
Volume: 146
Issue: 8
Pages: 3438-44
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Publication
11755537 | J:73621
First Author: Rehfeld JF
Year: 2002
Journal: FEBS Lett
Title: Progastrin processing differs in 7B2 and PC2 knockout animals: a role for 7B2 independent of action on PC2.
Volume: 510
Issue: 1-2
Pages: 89-93
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Publication
22013069 | J:178715
First Author: Helwig M
Year: 2011
Journal: J Biol Chem
Title: Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis.
Volume: 286
Issue: 49
Pages: 42504-13
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Publication
10873584 | J:62889
First Author: Vishnuvardhan D
Year: 2000
Journal: Biochem Biophys Res Commun
Title: PC2 and 7B2 null mice demonstrate that PC2 is essential for normal pro-CCK processing.
Volume: 273
Issue: 1
Pages: 188-91
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Publication
11854475 | J:126986
First Author: Laurent V
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.
Volume: 99
Issue: 5
Pages: 3087-92
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Publication
15956344 | J:112500
First Author: Hardiman A
Year: 2005
Journal: J Mol Endocrinol
Title: Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry.
Volume: 34
Issue: 3
Pages: 739-51
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Publication
20412386 | J:161820
First Author: Wardman JH
Year: 2010
Journal: J Neurochem
Title: Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics.
Volume: 114
Issue: 1
Pages: 215-25
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Publication
16174778 | J:103825
First Author: Beinfeld MC
Year: 2005
Journal: J Biol Chem
Title: Cholecystokinin levels in prohormone convertase 2 knock-out mouse brain regions reveal a complex phenotype of region-specific alterations.
Volume: 280
Issue: 46
Pages: 38410-5
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Publication
12697744 | J:82967
First Author: Ni XP
Year: 2003
Journal: J Clin Invest
Title: Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse.
Volume: 111
Issue: 8
Pages: 1251-8
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Publication
12859669 | J:84637
First Author: Miller R
Year: 2003
Journal: J Neurochem
Title: Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice.
Volume: 86
Issue: 3
Pages: 556-63
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Publication
20138041 | J:329319
First Author: Fujita Y
Year: 2010
Journal: Gastroenterology
Title: Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion.
Volume: 138
Issue: 5
Pages: 1966-75
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Publication
11246872 | J:78535
First Author: Wang J
Year: 2001
Journal: Diabetes
Title: The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.
Volume: 50
Issue: 3
Pages: 534-9
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Publication
16893422 | J:117471
First Author: Poirier S
Year: 2006
Journal: J Neurochem
Title: Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system.
Volume: 98
Issue: 3
Pages: 838-50
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Publication
8262946 | J:131459
First Author: Breslin MB
Year: 1993
Journal: J Biol Chem
Title: Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.
Volume: 268
Issue: 36
Pages: 27084-93
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Publication
8397508 | J:135486
 
First Author: Benjannet S
Year: 1993
Journal: Biochem J
Title: Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.
Volume: 294 ( Pt 3)
Pages: 735-43
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Publication
1988934 | J:33623
First Author: Smeekens SP
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
Volume: 88
Issue: 2
Pages: 340-4
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7925129 | J:20976
First Author: Marcinkiewicz M
Year: 1994
Journal: Endocrinology
Title: Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.
Volume: 135
Issue: 4
Pages: 1651-60
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12358783 | J:78623
First Author: Villeneuve P
Year: 2002
Journal: J Neurochem
Title: Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.
Volume: 82
Issue: 4
Pages: 783-93
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22396549 | J:184882
First Author: Refaie S
Year: 2012
Journal: J Biol Chem
Title: Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.
Volume: 287
Issue: 18
Pages: 14703-17
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7720862 | J:24358
First Author: Benjannet S
Year: 1995
Journal: FEBS Lett
Title: Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex.
Volume: 362
Issue: 2
Pages: 151-5
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7730317 | J:34511
First Author: Rothenberg ME
Year: 1995
Journal: J Biol Chem
Title: Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro.
Volume: 270
Issue: 17
Pages: 10136-46
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Publication
18554181 | J:140372
First Author: Rehfeld JF
Year: 2008
Journal: Biochem J
Title: Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.
Volume: 415
Issue: 1
Pages: 35-43
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Publication
16476726 | J:112681
First Author: Ugleholdt R
Year: 2006
Journal: J Biol Chem
Title: Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.
Volume: 281
Issue: 16
Pages: 11050-7
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Publication
15181538 | J:90699
First Author: Warden CH
Year: 2004
Journal: Mamm Genome
Title: Identification of a congenic mouse line with obesity and body length phenotypes.
Volume: 15
Issue: 6
Pages: 460-71
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Publication
19647035 | J:154947
First Author: Kedees MH
Year: 2009
Journal: Mol Cell Endocrinol
Title: Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia.
Volume: 311
Issue: 1-2
Pages: 69-76
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9242664 | J:139345
First Author: Schaner P
Year: 1997
Journal: J Biol Chem
Title: Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.
Volume: 272
Issue: 32
Pages: 19958-68
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Publication
8940009 | J:137491
First Author: Decroly E
Year: 1996
Journal: J Biol Chem
Title: Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.
Volume: 271
Issue: 48
Pages: 30442-50
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1765368 | J:419
First Author: Seidah NG
Year: 1991
Journal: Genomics
Title: Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region).
Volume: 11
Issue: 1
Pages: 103-7
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14693708 | J:87252
First Author: Marzban L
Year: 2004
Journal: Diabetes
Title: Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
Volume: 53
Issue: 1
Pages: 141-8
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10701998 | J:59052
First Author: Seidah NG
Year: 1999
Journal: Brain Res
Title: Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.
Volume: 848
Issue: 1-2
Pages: 45-62
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Publication
17050541 | J:117652
First Author: Zhu X
Year: 2006
Journal: J Biol Chem
Title: On the processing of proghrelin to ghrelin.
Volume: 281
Issue: 50
Pages: 38867-70
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Publication
18410501 | J:137265
First Author: Funkelstein L
Year: 2008
Journal: J Neurochem
Title: Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression.
Volume: 106
Issue: 1
Pages: 384-91
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Publication
19837164 | J:158324
First Author: Minokadeh A
Year: 2010
Journal: Mol Cell Neurosci
Title: Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression.
Volume: 43
Issue: 1
Pages: 98-107
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Publication
9452465 | J:45717
First Author: Furuta M
Year: 1998
Journal: J Biol Chem
Title: Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.
Volume: 273
Issue: 6
Pages: 3431-7
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Publication
17536020 | J:127206
First Author: Chiu S
Year: 2007
Journal: Physiol Genomics
Title: Identification of positional candidate genes for body weight and adiposity in subcongenic mice.
Volume: 31
Issue: 1
Pages: 75-85
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1429684 | J:52522
First Author: Steiner DF
Year: 1992
Journal: J Biol Chem
Title: The new enzymology of precursor processing endoproteases.
Volume: 267
Issue: 33
Pages: 23435-8
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8389457 | J:35634
First Author: Marcinkiewicz M
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.
Volume: 90
Issue: 11
Pages: 4922-6
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9291583 | J:42730
First Author: Rancourt SL
Year: 1997
Journal: Dev Genet
Title: Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation.
Volume: 21
Issue: 1
Pages: 75-81
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Publication
10818213 | J:80573
First Author: Wang CC
Year: 2000
Journal: Mamm Genome
Title: Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals.
Volume: 11
Issue: 6
Pages: 466-8
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15337773 | J:92513
First Author: Jurczyk A
Year: 2004
Journal: J Cell Biol
Title: Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly.
Volume: 166
Issue: 5
Pages: 637-43
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Publication
26261055 | J:236511
 
First Author: Yu R
Year: 2016
Journal: Mol Cell Endocrinol
Title: Animal models of spontaneous pancreatic neuroendocrine tumors.
Volume: 421
Pages: 60-7
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10894496 | J:62933
First Author: Kayo T
Year: 2000
Journal: Comp Med
Title: Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain.
Volume: 50
Issue: 3
Pages: 296-302
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7916325 | J:18309
First Author: Hess EJ
Year: 1994
Journal: Genomics
Title: Deletion map of the coloboma (Cm) locus on mouse chromosome 2.
Volume: 21
Issue: 1
Pages: 257-61
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23027401 | J:191140
First Author: Grigoryan M
Year: 2012
Journal: Dev Dyn
Title: Phenotype of entero-endocrine L cells becomes restricted during development.
Volume: 241
Issue: 12
Pages: 1986-92
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17366624 | J:119468
First Author: Kedees MH
Year: 2007
Journal: Dev Dyn
Title: Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling.
Volume: 236
Issue: 4
Pages: 1126-33
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7819324 | J:23191
First Author: Seidah NG
Year: 1994
Journal: Biochimie
Title: The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.
Volume: 76
Issue: 3-4
Pages: 197-209
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9885250 | J:52417
First Author: Constam DB
Year: 1999
Journal: J Cell Biol
Title: Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.
Volume: 144
Issue: 1
Pages: 139-49
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26516211 | J:227851
First Author: Pataskar A
Year: 2016
Journal: EMBO J
Title: NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program.
Volume: 35
Issue: 1
Pages: 24-45
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16627579 | J:129652
First Author: Vuguin PM
Year: 2006
Journal: Endocrinology
Title: Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.
Volume: 147
Issue: 9
Pages: 3995-4006
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Publication
17426285 | J:121843
First Author: Kita A
Year: 2007
Journal: Mol Endocrinol
Title: Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development.
Volume: 21
Issue: 6
Pages: 1458-66
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Publication
15181537 | J:90700
First Author: Diament AL
Year: 2004
Journal: Mamm Genome
Title: A novel mouse Chromosome 2 congenic strain with obesity phenotypes.
Volume: 15
Issue: 6
Pages: 452-9
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Publication
12049785 | J:77320
First Author: Wilson ME
Year: 2002
Journal: Mech Dev
Title: Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.
Volume: 115
Issue: 1-2
Pages: 171-6
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16163737 | J:104961
First Author: St Germain C
Year: 2005
Journal: Mol Reprod Dev
Title: Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.
Volume: 72
Issue: 4
Pages: 483-93
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Publication
20377917 | J:160437
 
First Author: Dames P
Year: 2010
Journal: BMC Dev Biol
Title: Relative roles of the different Pax6 domains for pancreatic alpha cell development.
Volume: 10
Pages: 39
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Publication
15680365 | J:96332
First Author: Lee CS
Year: 2005
Journal: Dev Biol
Title: Foxa2 is required for the differentiation of pancreatic alpha-cells.
Volume: 278
Issue: 2
Pages: 484-95
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Publication
15587270 | J:94589
First Author: Lamotte L
Year: 2004
Journal: Transgenic Res
Title: Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.
Volume: 13
Issue: 5
Pages: 463-73
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Publication
12933680 | J:85590
First Author: Vincent M
Year: 2003
Journal: Endocrinology
Title: Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.
Volume: 144
Issue: 9
Pages: 4061-9
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1354647 | J:1676
First Author: Copeland NG
Year: 1992
Journal: Genomics
Title: Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.
Volume: 13
Issue: 4
Pages: 1356-8
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Publication
16465594 | J:105312
First Author: MacLaren EJ
Year: 2006
Journal: Mamm Genome
Title: Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs.
Volume: 17
Issue: 2
Pages: 147-56
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Publication
11076772 | J:65594
First Author: Sander M
Year: 2000
Journal: Development
Title: Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
Volume: 127
Issue: 24
Pages: 5533-40
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9616220 | J:48038
First Author: Mehrabian M
Year: 1998
Journal: J Clin Invest
Title: Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.
Volume: 101
Issue: 11
Pages: 2485-96
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Publication
17367776 | J:122509
First Author: Raetzman LT
Year: 2007
Journal: Dev Biol
Title: Hes1 is required for pituitary growth and melanotrope specification.
Volume: 304
Issue: 2
Pages: 455-66
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Publication
18996108 | J:143548
First Author: Himes AD
Year: 2009
Journal: Dev Biol
Title: Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1.
Volume: 325
Issue: 1
Pages: 151-61
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Publication
20876279 | J:165252
First Author: Mesnard D
Year: 2010
Journal: J Cell Biol
Title: Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.
Volume: 191
Issue: 1
Pages: 129-39
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Publication
32694784 | J:310126
First Author: Quarta C
Year: 2019
Journal: Nat Metab
Title: Functional identity of hypothalamic melanocortin neurons depends on Tbx3.
Volume: 1
Issue: 2
Pages: 222-235
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