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Search results 701 to 800 out of 908 for Sim1

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Type Details Score
Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
24315371 | J:206137
First Author: Xu Y
Year: 2013
Journal: Cell Metab
Title: Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.
Volume: 18
Issue: 6
Pages: 860-70
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Publication
37033219 | J:345404
 
First Author: Semple EA
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice.
Volume: 14
Pages: 983670
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Publication
16709610 | J:113731
First Author: Kublaoui BM
Year: 2006
Journal: Endocrinology
Title: SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.
Volume: 147
Issue: 10
Pages: 4542-9
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Publication
27334347 | J:257110
 
First Author: Soylu-Kucharz R
Year: 2016
Journal: Sci Rep
Title: Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington's disease.
Volume: 6
Pages: 28322
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Publication
28053040 | J:237909
First Author: Ghosal S
Year: 2017
Journal: J Neurosci
Title: Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.
Volume: 37
Issue: 1
Pages: 184-193
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Publication
27106110 | J:236943
First Author: Novoselova TV
Year: 2016
Journal: J Endocrinol
Title: Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol.
Volume: 230
Issue: 1
Pages: 13-26
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Publication
30615192 | J:332619
First Author: Nyamugenda E
Year: 2019
Journal: J Neurochem
Title: Injury to hypothalamic Sim1 neurons is a common feature of obesity by exposure to high-fat diet in male and female mice.
Volume: 149
Issue: 1
Pages: 73-97
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HT Experiment
GSE166616 | Ectopic misexpression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to hyperphagia and neurodevelopmental defects in Sim1 haploinsufficiency
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
35020776 | J:318734
First Author: Tanaka J
Year: 2022
Journal: PLoS One
Title: Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
Volume: 17
Issue: 1
Pages: e0262577
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Allele
Gt(ROSA)26Sor<tm2Ndav> | MGI:6287267
 
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Nadav Ahituv
Allele Type: Targeted
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MP Term
MP:0021105 | abnormal ventral interneuron 3 morphology
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Publication
32229422 | J:308997
 
First Author: Xiao C
Year: 2020
Journal: Mol Metab
Title: BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice.
Volume: 36
Pages: 100969
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Allele
Sim1<tm1.1(cre)Gld> | MGI:3839912
Name: single-minded family bHLH transcription factor 1; targeted mutation 1.1, Martyn Goulding
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Sim1<tm1.1(cre)Lowl> | MGI:7444470
Name: single-minded family bHLH transcription factor 1; targeted mutation 1.1, Bradford B Lowell
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Tg(Sim1-cre)KJ27Gsat | MGI:4847416
Name: transgene insertion KJ27, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Sim1-cre)2Lowl | MGI:3692527
Name: transgene insertion 2, Bradford B Lowell
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Rr53<em1Axvi> | MGI:7489590
Name: regulatory region 53; endonuclease-mediated mutation 1, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Tg(Sim1-cre)KJ21Gsat | MGI:4940654
Name: transgene insertion KJ21, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Sim1-cre)KJ40Gsat | MGI:5051778
Name: transgene insertion KJ40, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Sim1-cre)1Lowl | MGI:3692526
Name: transgene insertion 1, Bradford B Lowell
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
34788630 | J:321532
First Author: Yoo ES
Year: 2021
Journal: Cell Rep
Title: Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents.
Volume: 37
Issue: 7
Pages: 109997
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Publication
26098212 | J:224544
First Author: Xu P
Year: 2015
Journal: J Clin Invest
Title: Estrogen receptor-α in medial amygdala neurons regulates body weight.
Volume: 125
Issue: 7
Pages: 2861-76
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Publication
27595593 | J:238330
First Author: Zhang R
Year: 2017
Journal: Mol Psychiatry
Title: Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice.
Volume: 22
Issue: 5
Pages: 733-744
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Publication
16484282 | J:112724
First Author: Metz RP
Year: 2006
Journal: J Biol Chem
Title: Differential transcriptional regulation by mouse single-minded 2s.
Volume: 281
Issue: 16
Pages: 10839-48
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Protein
Q56DJ6
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
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Publication
7756254 | -
First Author: Borgstahl GE
Year: 1995
Journal: Biochemistry
Title: 1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore.
Volume: 34
Issue: 19
Pages: 6278-87
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Publication
11091086 | -
First Author: Coumailleau P
Year: 2000
Journal: Mech Dev
Title: Characterization and developmental expression of xSim, a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded.
Volume: 99
Issue: 1-2
Pages: 163-6
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Protein Domain
IPR010578 | SIM_C
Type: Domain
Description: In Drosophila, single-minded (sim) is a transcription factor that acts as the master regulator of neurogenesis. Two mammalian homologues of Sim which have been identified, Sim1 and Sim2, are novel heterodimerisation partners for ARNT in vitro, and may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism []. SIM2 is thought to contribute to some specific Down syndrome phenotypes []. There is a high level of homology among mammalian and Drosophila sim proteins in their amino-terminal half where the conserved bHLH, PAS () and PAC motifs are present (). The PAC region occurs C-terminal to the PAS domains and are proposed to contribute to the PAS domain fold [, , ]. In contrast, the carboxy-terminal parts are only conserved in vertebrates []. The Sim1 C terminus contains a Ser-rich region, whereas the Sim2 C terminus both contain Ser/Thr-rich regions, Pro/Ser-rich regions, Pro/Ala-rich regions, and positively charged regions. Sim2s, a splice variant of Sim2, still contains the Ser/Thr- and Pro/Ser-rich regions shown to harbor repressive activities, but is missing the Pro/Ala-rich repressor region [, , ].
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Allele
Tg(Sim1-cre)#Lowl | MGI:5447031
Name: transgene insertion, Bradford B Lowell
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:5004196 | STOCK Tg(Sim1-cre)KJ27Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Strain
MGI:6348308 | FVB/NCrl-Rr53<em1Axvi>/Mmucd
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
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Strain
MGI:7489912 | FVB-Rr53<em1Axvi>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:5004364 | STOCK Tg(Sim1-cre)KJ21Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
31839450 | J:284859
First Author: Vandrey B
Year: 2020
Journal: Curr Biol
Title: Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory.
Volume: 30
Issue: 1
Pages: 169-175.e5
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Strain
MGI:5519909 | B6.FVB(Cg)-Tg(Sim1-cre)KJ40Gsat/Mmucd
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:5519907 | STOCK Tg(Sim1-cre)KJ40Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Strain
MGI:3771875 | B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:3699159 | STOCK Tg(Sim1-cre)1Lowl/J
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Rr53/Rr53
Background: FVB-Rr53
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sim1/Sim1<+>
Background: involves: 129S6/SvEvTac
Zygosity: ht
Has Mutant Allele: true
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Publication
30698681 | J:271662
First Author: Singha AK
Year: 2019
Journal: Endocrinology
Title: Glucose-Lowering by Leptin in the Absence of Insulin Does Not Fully Rely on the Central Melanocortin System in Male Mice.
Volume: 160
Issue: 3
Pages: 651-663
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Allele
Gli2<tm5(GLI3)Alj> | MGI:3032718
Name: GLI-Kruppel family member GLI2; targeted mutation 5, Alexandra L Joyner
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Shh<tm1Ptch> | MGI:3051902
 
Name: sonic hedgehog; targeted mutation 1, Pao-Tien Chuang
Allele Type: Targeted
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Genotype
Genotype
Symbol: Gli1/Gli1 Gli2/Gli2
Background: involves: 129S6/SvEvTac * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Publication
26046806 | J:226372
First Author: Solomon MB
Year: 2015
Journal: Endocrinology
Title: Neuroendocrine Function After Hypothalamic Depletion of Glucocorticoid Receptors in Male and Female Mice.
Volume: 156
Issue: 8
Pages: 2843-53
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Publication
21920410 | J:182812
 
First Author: Dubreucq S
Year: 2012
Journal: Neuroscience
Title: Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors.
Volume: 204
Pages: 230-44
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Publication
36307046 | J:330964
 
First Author: Deng Y
Year: 2022
Journal: Mol Metab
Title: Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice.
Volume: 66
Pages: 101622
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Publication
37232416 | J:336093
 
First Author: Wesselman HM
Year: 2023
Journal: Development
Title: Esrrγa regulates nephron and ciliary development by controlling prostaglandin synthesis.
Volume: 150
Issue: 10
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Sim1/Sim1<+>
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sim1/Sim1<+> Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld/?
Background: involves: 129S1/Sv * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nr3c1/Nr3c1<+> Tg(Sim1-cre)1Lowl/?
Background: involves: 129 * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nr3c1/Nr3c1 Tg(Sim1-cre)1Lowl/?
Background: involves: 129 * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1 Tg(Sim1-cre)1Lowl/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mrap2/Mrap2 Tg(Sim1-cre)1Lowl/?
Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mc4r/Mc4r Tg(Sim1-cre)1Lowl/?
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rai1/Rai1 Tg(Sim1-cre)1Lowl/?
Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rai1/Rai1<+> Tg(Sim1-cre)1Lowl/?
Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh Tg(Sim1-cre)1Lowl/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Akirin2/Akirin2<+> Tg(Sim1-cre)1Lowl/?
Background: involves: 129X1/SvJ * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Akirin2/Akirin2 Tg(Sim1-cre)1Lowl/?
Background: involves: 129X1/SvJ * FVB
Zygosity: cn
Has Mutant Allele: true
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Publication
9382818 | -
First Author: Ponting CP
Year: 1997
Journal: Curr Biol
Title: PAS: a multifunctional domain family comes to light.
Volume: 7
Issue: 11
Pages: R674-7
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Allele
Rnf220<em1Chek> | MGI:6393918
Name: ring finger protein 220; endonuclease-mediated mutation 1, Cheol-Hee Kim
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Gli2/Gli2
Background: involves: Swiss Webster
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh
Background: involves: 129P2/OlaHsd * FVB/N * various
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Ptch1/Ptch1
Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pax6/Pax6
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3
Background: involves: 101/H * C3H/HeH * C57BL * CBA/H * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Publication
23486953 | J:196357
First Author: de Kloet AD
Year: 2013
Journal: J Neurosci
Title: Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity.
Volume: 33
Issue: 11
Pages: 4825-33
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Publication
26637556 | J:232504
First Author: Biancardi VC
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus.
Volume: 310
Issue: 3
Pages: H404-15
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Publication
25587115 | J:235112
First Author: Gilbert ML
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype.
Volume: 308
Issue: 6
Pages: F627-38
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Publication
23979842 | J:210716
First Author: Laryea G
Year: 2013
Journal: Mol Endocrinol
Title: Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity.
Volume: 27
Issue: 10
Pages: 1655-65
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Publication
36180454 | J:330249
First Author: Strembitska A
Year: 2022
Journal: Nat Commun
Title: Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion.
Volume: 13
Issue: 1
Pages: 5761
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Publication
21209091 | J:170536
First Author: Chiappini F
Year: 2011
Journal: J Biol Chem
Title: Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity.
Volume: 286
Issue: 10
Pages: 8094-105
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Publication
27791019 | J:238802
First Author: Samuelsson AS
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity.
Volume: 113
Issue: 43
Pages: 12298-12303
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Genotype
Genotype
Symbol: Mc4r/Mc4r Tg(Sim1-cre)1Lowl/?
Background: involves: 129S4/SvJae * C57BL/6J * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mc4r/Mc4r Tg(Sim1-cre)2Lowl/?
Background: involves: 129S4/SvJae * C57BL/6J * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mc4r/Mc4r Tg(Sim1-cre)#Lowl/?
Background: involves: 129S4/SvJae * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Sim1-cre)1Lowl/?
Background: involves: 129S4/SvJaeSor * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Sim1-cre)KJ27Gsat/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dnmt3a/Dnmt3a Tg(Sim1-cre)#Lowl/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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