Type |
Details |
Score |
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2006-07-27 |
Strength: |
Very strong |
Sex: |
Male |
Emaps: |
EMAPS:3281228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3639189 |
Age: |
postnatal day 50 |
Image: |
Mouse 135983 - Image 12564046 |
Note: |
Expression is present in practically all cells of the parathyroid gland. |
Specimen Label: |
Mouse 135983 - Image 12564046 |
Detected: |
true |
Specimen Num: |
40 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2006-07-27 |
Strength: |
Strong |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:3639189 |
Age: |
postnatal day 50 |
Image: |
Mouse 135993 - Image 12333546 |
Note: |
Expression is frequently seen in the blood vessels of the uterus. |
Specimen Label: |
Mouse 135993 - Image 12333546 |
Detected: |
true |
Specimen Num: |
58 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2006-07-27 |
Strength: |
Weak |
Sex: |
Male |
Emaps: |
EMAPS:3521728 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:3639189 |
Age: |
postnatal day 50 |
Image: |
Mouse 135983 - Image 12294336 |
Note: |
There is occasional staining in the basket cells. |
Specimen Label: |
Mouse 135983 - Image 12294336 |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2006-07-27 |
Strength: |
Very strong |
Sex: |
Male |
Emaps: |
EMAPS:3514628 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:3639189 |
Age: |
postnatal day 50 |
Image: |
Mouse 135983 - Image 12564051 |
Note: |
Expression is frequently seen in the arterioles of the kidney. |
Specimen Label: |
Mouse 135983 - Image 12564051 |
Detected: |
true |
Specimen Num: |
44 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2006-07-27 |
Strength: |
Strong |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:3639189 |
Age: |
postnatal day 50 |
Image: |
Mouse 135993 - Image 12333545 |
Note: |
Expression is frequently seen in the blood vessels of the ovary. |
Specimen Label: |
Mouse 135993 - Image 12333545 |
Detected: |
true |
Specimen Num: |
57 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2006-07-27 |
Strength: |
Strong |
Sex: |
Male |
Emaps: |
EMAPS:1868228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:3639189 |
Age: |
postnatal day 50 |
Image: |
Mouse 135983 - Image 12288449 |
Note: |
Expression is frequently seen in the smooth muscle cells. |
Specimen Label: |
Mouse 135983 - Image 12288449 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2006-07-27 |
Strength: |
Moderate |
Sex: |
Male |
Emaps: |
EMAPS:1868228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:3639189 |
Age: |
postnatal day 50 |
Image: |
Mouse 135983 - Image 12288450 |
Note: |
There is scattered expression in the nerves of the penis. |
Specimen Label: |
Mouse 135983 - Image 12288450 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2006-07-27 |
Strength: |
Moderate |
Sex: |
Male |
Emaps: |
EMAPS:1868228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:3639189 |
Age: |
postnatal day 50 |
|
Note: |
There is scattered expression in the blood vessels of the penis. |
Specimen Label: |
Mouse 135983 |
Detected: |
true |
Specimen Num: |
48 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2006-07-27 |
Strength: |
Weak |
Sex: |
Male |
Emaps: |
EMAPS:1786928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3639189 |
Age: |
postnatal day 50 |
Image: |
Mouse 135983 - Image 12316227 |
Note: |
Expression is frequently seen in the valves. |
Specimen Label: |
Mouse 135983 - Image 12316227 |
Detected: |
true |
Specimen Num: |
35 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7275252 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-05-09 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3286323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:7275301 |
Age: |
embryonic day 15.0 |
Image: |
2H |
Note: |
Expression is in the dental pulp. |
Specimen Label: |
2H |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7275252 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-05-09 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3286323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:7275301 |
Age: |
embryonic day 15.0 |
Image: |
2G |
Note: |
Expression is in the dental pulp. |
Specimen Label: |
2G |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7275252 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-05-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3808426 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7275301 |
Age: |
embryonic day 18.0 |
Image: |
3B |
Note: |
Expression is in ameloblasts. |
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7275252 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-05-09 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3808427 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7275301 |
Age: |
postnatal day 1 |
Image: |
3D |
Note: |
Expression is in ameloblasts. |
Specimen Label: |
3D |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7275252 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-05-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3808428 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7275301 |
Age: |
postnatal day 12 |
Image: |
3F |
Note: |
Expression is in ameloblasts. |
Specimen Label: |
3F |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma R |
Year: |
2007 |
Journal: |
J Neurochem |
Title: |
Minimal role for caspase 12 in the unfolded protein response in oligodendrocytes in vivo. |
Volume: |
101 |
Issue: |
4 |
Pages: |
889-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wootz H |
Year: |
2006 |
Journal: |
Exp Cell Res |
Title: |
XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice. |
Volume: |
312 |
Issue: |
10 |
Pages: |
1890-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiraishi H |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1. |
Volume: |
119 |
Issue: |
Pt 19 |
Pages: |
3958-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moorwood C |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Caspase-12 ablation preserves muscle function in the mdx mouse. |
Volume: |
23 |
Issue: |
20 |
Pages: |
5325-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakagawa T |
Year: |
2000 |
Journal: |
Nature |
Title: |
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. |
Volume: |
403 |
Issue: |
6765 |
Pages: |
98-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brezniceanu ML |
Year: |
2010 |
Journal: |
J Am Soc Nephrol |
Title: |
Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy. |
Volume: |
21 |
Issue: |
6 |
Pages: |
943-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanges D |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors. |
Volume: |
103 |
Issue: |
46 |
Pages: |
17366-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tan Y |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis. |
Volume: |
281 |
Issue: |
23 |
Pages: |
16016-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mockel A |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection ability. |
Volume: |
287 |
Issue: |
44 |
Pages: |
37483-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dupaul-Chicoine J |
Year: |
2010 |
Journal: |
Immunity |
Title: |
Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. |
Volume: |
32 |
Issue: |
3 |
Pages: |
367-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baltzis D |
Year: |
2004 |
Journal: |
J Virol |
Title: |
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR. |
Volume: |
78 |
Issue: |
23 |
Pages: |
12747-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morishima N |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. |
Volume: |
277 |
Issue: |
37 |
Pages: |
34287-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yin YB |
Year: |
2005 |
Journal: |
Acta Biochim Biophys Sin (Shanghai) |
Title: |
Comparative study of apoptosis-related gene loci in human, mouse and rat genomes. |
Volume: |
37 |
Issue: |
5 |
Pages: |
341-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kerrigan SW |
Year: |
2004 |
Journal: |
Blood |
Title: |
Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation. |
Volume: |
104 |
Issue: |
5 |
Pages: |
1327-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vesela B |
Year: |
2015 |
Journal: |
J Mol Histol |
Title: |
Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. |
Volume: |
46 |
Issue: |
4-5 |
Pages: |
443-55 |
|
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•
•
•
•
|
Publication |
First Author: |
Diamanti MA |
Year: |
2017 |
Journal: |
J Exp Med |
Title: |
IKKα controls ATG16L1 degradation to prevent ER stress during inflammation. |
Volume: |
214 |
Issue: |
2 |
Pages: |
423-437 |
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•
•
•
•
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Publication |
First Author: |
Hidvegi T |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. |
Volume: |
290 |
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50 |
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29742-57 |
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•
•
•
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Publication |
First Author: |
Skeldon AM |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance. |
Volume: |
196 |
Issue: |
1 |
Pages: |
437-47 |
|
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•
•
•
•
|
Publication |
First Author: |
Wang P |
Year: |
2010 |
Journal: |
Nat Immunol |
Title: |
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. |
Volume: |
11 |
Issue: |
10 |
Pages: |
912-9 |
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•
•
•
•
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Publication |
First Author: |
Harding HP |
Year: |
2000 |
Journal: |
Mol Cell |
Title: |
Perk is essential for translational regulation and cell survival during the unfolded protein response. |
Volume: |
5 |
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5 |
Pages: |
897-904 |
|
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•
•
•
•
|
Publication |
First Author: |
Niikura Y |
Year: |
2010 |
Journal: |
Cell Death Differ |
Title: |
BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD). |
Volume: |
17 |
Issue: |
6 |
Pages: |
1011-24 |
|
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•
•
•
•
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Publication |
First Author: |
Vesela B |
Year: |
2020 |
Journal: |
Front Cell Dev Biol |
Title: |
Caspase-12 Is Present During Craniofacial Development and Participates in Regulation of Osteogenic Markers. |
Volume: |
8 |
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Pages: |
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•
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Journal: |
J Cell Biol |
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Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. |
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Cell Death Differ |
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Caspase-14, a keratinocyte specific caspase: mRNA splice variants and expression pattern in embryonic and adult mouse. |
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Deltagen Inc |
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NIH initiative supporting placement of Deltagen, Inc. mice into public repositories |
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Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Allele |
Name: |
transgene insertion 1, Joseph Buxbaum |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Publication |
First Author: |
Saleh M |
Year: |
2004 |
Journal: |
Nature |
Title: |
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. |
Volume: |
429 |
Issue: |
6987 |
Pages: |
75-9 |
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Publication |
First Author: |
Fischer H |
Year: |
2002 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Human caspase 12 has acquired deleterious mutations. |
Volume: |
293 |
Issue: |
2 |
Pages: |
722-6 |
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Protein Domain |
Type: |
Family |
Description: |
This entry represents caspase-12 (CASP12). In mice, caspase-12 is associated with apoptosis resulting from endoplasmic reticulum stress []. In humans, CASP12 is inactive because of a number of mutations, including a frame shift mutation and a premature stop codon, as well as site-specific mutations affecting the SHG motif around the active site histidine []. Different isoforms of the protein are generated, with a form known as Csp12-L more prevalent in Africans and African-Americans, which confers hypo-responsiveness to lipopolysaccharide-stimulated cytokine production and may promote greater sensitivity to sepsis []. |
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Publication |
First Author: |
Yang IV |
Year: |
2011 |
Journal: |
Mamm Genome |
Title: |
A locus on chromosome 9 is associated with differential response of 129S1/SvImJ and FVB/NJ strains of mice to systemic LPS. |
Volume: |
22 |
Issue: |
9-10 |
Pages: |
518-29 |
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Strain |
Attribute String: |
mutant strain, transgenic, targeted mutation, congenic, variant allele |
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Publication |
First Author: |
Kajiwara Y |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
A critical role for human caspase-4 in endotoxin sensitivity. |
Volume: |
193 |
Issue: |
1 |
Pages: |
335-43 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
231
|
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
349
|
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
349
|
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
|
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
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Fragment?: |
false |
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