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Cdc45
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0.039s
Type
Details
Score
Protein Domain
Type:
Family
Description:
Geminin coiled-coil domain-containing protein 1 (GEMC1) is a regulator of DNA replication. It promotes initiation of chromosomal DNA replication by mediating TopBP1- and cdk2-dependent recruitment of cdc45 onto replication origins []. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein. However, only some of the amino acid residues critical for geminin function are conserved in GEMC1 [].
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Protein
Organism:
Mus musculus/domesticus
Length:
1889
Fragment?:
false
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Protein
Organism:
Mus musculus/domesticus
Length:
718
Fragment?:
false
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Protein
Organism:
Mus musculus/domesticus
Length:
968
Fragment?:
false
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Protein
Organism:
Mus musculus/domesticus
Length:
968
Fragment?:
false
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Protein
Organism:
Mus musculus/domesticus
Length:
409
Fragment?:
false
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Publication
First Author:
Kumagai A
Year:
2010
Journal:
Cell
Title:
Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.
Volume:
140
Issue:
3
Pages:
349-59
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Publication
First Author:
Sansam CL
Year:
2010
Journal:
Genes Dev
Title:
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.
Volume:
24
Issue:
2
Pages:
183-94
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Publication
First Author:
Kneissl M
Year:
2003
Journal:
J Mol Biol
Title:
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
Volume:
327
Issue:
1
Pages:
111-28
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Publication
First Author:
Liu H
Year:
2010
Journal:
Nature
Title:
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
Volume:
467
Issue:
7313
Pages:
343-6
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Publication
First Author:
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:
2005
Journal:
Database Download
Title:
MGI download of GENSAT transgene data
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