FANCB (also known as FAAP95) is a component of the Fanconi anemia (FA) core complex []. The FA core complex mediates FANCD2 ubiquitination, a key activation step in the FA DNA damage response pathway [, , ]. The FANCB and the FA pathway also play a critical role in germ cell development []and in the maintenance of hematopoietic stem cell function [].FA is a recessive genetic disorder characterised by congenital abnormalities, progressive bone marrow failure and cancer susceptibility []. Eight proteins (FANCA, B, C, E, F, G, L and M) encoded by the FA causative genes have been demonstrated to form the FA nuclear core complex.
