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Search results 201 to 263 out of 263 for Cd48

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Type Details Score
Allele
Cd48<+> | MGI:2430267
   
Name: CD48 antigen; wild type
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Publication
20363967 | J:160444
First Author: Fortenbery NR
Year: 2010
Journal: J Immunol
Title: SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation.
Volume: 184
Issue: 9
Pages: 5065-74
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Allele
Cd48<tm1.1Vei> | MGI:6149228
Name: CD48 antigen; targeted mutation 1.1, Andre Veillette
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cd48<tm1Rsr> | MGI:2180770
Name: CD48 antigen; targeted mutation 1, Hans Reiser
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cd48<em1Cya> | MGI:7582860
Name: CD48 antigen; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cd48<tm1a(EUCOMM)Hmgu> | MGI:5472671
Name: CD48 antigen; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Strain
MGI:5524249 | B6.129S4-Cd48<tm1Rsr>/EpaulJ
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:3848364 | B6.129S4-Cd48<tm1Rsr>
Attribute String: congenic, targeted mutation
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Allele
Cd48<tm1e(EUCOMM)Hmgu> | MGI:5472448
Name: CD48 antigen; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cd48<em1Gpt> | MGI:7296597
Name: CD48 antigen; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:7590959 | C57BL/6J-Cd48<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Cd48<tm1(KOMP)Mbp> | MGI:5014547
Name: CD48 antigen; targeted mutation 1, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Cd48/Cd48
Background: B6.129S4-Cd48
Zygosity: hm
Has Mutant Allele: true
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Publication
12734329 | -
First Author: Lee KM
Year: 2003
Journal: J Immunol
Title: Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells.
Volume: 170
Issue: 10
Pages: 4881-5
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Publication
15850375 | -
First Author: Ames JB
Year: 2005
Journal: Biochemistry
Title: NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition.
Volume: 44
Issue: 17
Pages: 6416-23
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Protein Domain
IPR024303 | NK_rcpt_2B4_Ig_dom
Type: Domain
Description: 2B4 is a transmembrane receptor which is expressed primarily on natural killer (NK) cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells []. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two β-sheets. One of the β-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function [].This entry represents the 2B4 immunoglobulin domain.
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Protein Domain
IPR024304 | NK_rcpt_2B4
Type: Family
Description: 2B4 is a transmembrane receptor which is expressed primarily on natural killer (NK) cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells []. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two β-sheets. One of the β-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function [].
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Protein Domain
IPR015632 | CD2
Type: Family
Description: The CD2 adhesion molecule is a cell surface protein expressed by T cells and natural killer cells. CD2's extracellular domain contains immunoglobulin-like domains that are glycosylated at two sites and can mediate homodimerisation []. Ligation of CD2 by CD58 in humans or CD48 in mice helps T cells adhere to antigen-presenting cells, and initiates signal transduction pathways that enhance signalling through the T cell receptor for antigen. CD2 knockout mice exhibit essentially normal immune function [], and it is thought that CD2 is somewhat functionally redundant with other T cell co-stimulatory receptors such as CD28 [].
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Protein Domain
IPR015714 | Lymphocyte_func-assoc_Ag_3
Type: Family
Description: The LFA-3 (CD2) adhesion molecule is a cell surface protein expressed by T cells and natural killer cells. LFA-3's extracellular region contains immunoglobulin-like domains that are glycosylated at two sites and can mediate homodimerisation []. Ligation of LFA3 by CD58 in humans or CD48 in mice helps T cells adhere to antigen-presenting cells, and initiates signal transduction pathways that enhance signalling through the T cell receptor for antigen. LFA-3 knockout mice exhibit essentially normal immune function [], and it is thought that LFA-3 is somewhat functionally redundant with other T cell co-stimulatory receptors such as CD28 [].
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Publication
9314566 | J:111820
First Author: Wang J
Year: 1997
Journal: J Exp Med
Title: Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95.
Volume: 186
Issue: 7
Pages: 1171-6
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Publication
9834056 | J:51037
First Author: Latchman Y
Year: 1998
Journal: J Immunol
Title: Identification of the 2B4 molecule as a counter-receptor for CD48.
Volume: 161
Issue: 11
Pages: 5809-12
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Publication
12475217 | -
First Author: Chen HA
Year: 2002
Journal: Biochemistry
Title: The pH dependence of CD2 domain 1 self-association and 15N chemical exchange broadening is correlated with the anomalous pKa of Glu41.
Volume: 41
Issue: 50
Pages: 14680-8
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Publication
1358605 | J:3149
First Author: Killeen N
Year: 1992
Journal: EMBO J
Title: Development and function of T cells in mice with a disrupted CD2 gene.
Volume: 11
Issue: 12
Pages: 4329-36
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Publication
9794375 | -
First Author: Hutchcroft JE
Year: 1998
Journal: J Immunol
Title: Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28.
Volume: 161
Issue: 9
Pages: 4506-12
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Publication
11739483 | J:227396
First Author: Kambayashi T
Year: 2001
Journal: J Immunol
Title: Cutting edge: Regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions.
Volume: 167
Issue: 12
Pages: 6706-10
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Publication
10458751 | J:56786
First Author: Stepp SE
Year: 1999
Journal: Eur J Immunol
Title: Gene structure of the murine NK cell receptor 2B4: presence of two alternatively spliced isoforms with distinct cytoplasmic domains.
Volume: 29
Issue: 8
Pages: 2392-9
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Publication
19420357 | J:150760
First Author: McKinney-Freeman SL
Year: 2009
Journal: Blood
Title: Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.
Volume: 114
Issue: 2
Pages: 268-78
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Publication
8228228 | J:15522
First Author: Mathew PA
Year: 1993
Journal: J Immunol
Title: Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells.
Volume: 151
Issue: 10
Pages: 5328-37
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Publication
15998796 | J:100630
First Author: Bloch-Queyrat C
Year: 2005
Journal: J Exp Med
Title: Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.
Volume: 202
Issue: 1
Pages: 181-92
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Publication
11132158 | J:60849
First Author: Peck SR
Year: 2000
Journal: Immunogenetics
Title: Ly108: a new member of the mouse CD2 family of cell surface proteins.
Volume: 52
Issue: 1-2
Pages: 63-72
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Publication
27054584 | J:252393
First Author: Alari-Pahissa E
Year: 2016
Journal: PLoS One
Title: Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition.
Volume: 11
Issue: 4
Pages: e0153236
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Publication
26564814 | J:234522
First Author: Gonzalez Roldan N
Year: 2016
Journal: Eur J Immunol
Title: CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice.
Volume: 46
Issue: 2
Pages: 432-9
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Publication
16493031 | J:129400
First Author: Gao N
Year: 2006
Journal: J Immunol
Title: B cell induction of IL-13 expression in NK cells: role of CD244 and SLAM-associated protein.
Volume: 176
Issue: 5
Pages: 2758-64
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Publication
15356144 | J:92740
First Author: Mooney JM
Year: 2004
Journal: J Immunol
Title: The murine NK receptor 2B4 (CD244) exhibits inhibitory function independent of signaling lymphocytic activation molecule-associated protein expression.
Volume: 173
Issue: 6
Pages: 3953-61
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Publication
15634901 | J:94750
First Author: Vaidya SV
Year: 2005
Journal: J Immunol
Title: Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells.
Volume: 174
Issue: 2
Pages: 800-7
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Publication
18339657 | J:134466
First Author: Gao N
Year: 2008
Journal: Int Immunol
Title: Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes.
Volume: 20
Issue: 5
Pages: 645-57
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Publication
11513145 | J:70802
 
First Author: Boles KS
Year: 2001
Journal: Immunol Rev
Title: 2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes.
Volume: 181
Pages: 234-49
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Publication
11507070 | J:71198
First Author: Niethammer AG
Year: 2001
Journal: Cancer Res
Title: Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma.
Volume: 61
Issue: 16
Pages: 6178-84
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Publication
10458320 | J:57010
First Author: Boles KS
Year: 1999
Journal: Tissue Antigens
Title: Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4.
Volume: 54
Issue: 1
Pages: 27-34
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Publication
14764667 | J:88002
First Author: Gordy C
Year: 2004
Journal: J Immunol
Title: Visualization of antigen presentation by actin-mediated targeting of glycolipid-enriched membrane domains to the immune synapse of B cell APCs.
Volume: 172
Issue: 4
Pages: 2030-8
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Publication
18523281 | J:137232
First Author: Chlewicki LK
Year: 2008
Journal: J Immunol
Title: Molecular basis of the dual functions of 2B4 (CD244).
Volume: 180
Issue: 12
Pages: 8159-67
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Publication
19586919 | J:154885
First Author: Clarkson NG
Year: 2009
Journal: J Biol Chem
Title: Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1.
Volume: 284
Issue: 37
Pages: 24725-34
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Publication
18079432 | J:347202
First Author: Noda S
Year: 2008
Journal: Stem Cells
Title: Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population.
Volume: 26
Issue: 3
Pages: 646-55
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Protein
Q07763
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Q3TBI0
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q3S4B2
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
B9EK78
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q9ESE5
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
Q9JIE1
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q3TDI8
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Protein
D9J344
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
Q3S4B1
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Q3TAZ6
Organism: Mus musculus/domesticus
Length: 312  
Fragment?: false
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Publication
10542322 | J:58274
First Author: Chuang SS
Year: 1999
Journal: Biochim Biophys Acta
Title: Molecular cloning and characterization of the promoter region of murine natural killer cell receptor 2B4.
Volume: 1447
Issue: 2-3
Pages: 244-50
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Protein
Q9D806
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
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Protein
Q3UU70
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Publication
- | J:23411
 
First Author: Maltais LJ
Year: 1994
Journal: Mouse Genome
Title: Locus Map of mouse
Volume: 92
Pages: 62-85
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Protein
P08920
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
Q549Q4
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
Q9R201
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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