This entry represents the MBL-fold found in integrator complex subunit 11 (INTS11 or Int11, also known as RC-68). Integrator (INT) is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1-Int14 (Integrator subunits). Integrator complex has been implicated in a variety of Pol II transcription events including 3' end processing of snRNA, transcription initiation, promoter-proximal pausing, termination of protein-coding transcripts, and in HVS pre-miRNA 3' end processing [, ]. INTS11 is the endonuclease subunit for INT, responsible for the cleavage reaction at the 3' end of target RNAs []. INTS11 belongs to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions [].
