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Search results 1 to 100 out of 4281 for C3

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Hits by Category

Type Details Score
Gene
718 | C3
Type: gene
Organism: human
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Gene
703613 | C3
Type: gene
Organism: macaque, rhesus
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Gene
100216255 | c3
Type: gene
Organism: frog, western clawed
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Gene
24232 | C3
Type: gene
Organism: rat
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Gene
476728 | C3
Type: gene
Organism: dog, domestic
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Gene
455644 | C3
Type: gene
Organism: chimpanzee
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Gene
280677 | C3
Type: gene
Organism: cattle
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Gene
396370 | C3
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:88227 | C3
Type: protein_coding_gene
Organism: mouse, laboratory
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HT Sample
C3
Organism Name: mouse, laboratory
Sex: Female
Age: embryonic day 11.75
Stage: 19
Structure . Name: handplate
Notes: anterior handplate
Curation Status: Curated
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HT Sample
C3
 
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 18.5
Stage: 26
Structure . Name: liver
Curation Status: Curated
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HT Sample
C3
 
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 8
Stage: 28
Structure . Name: lung
Curation Status: Curated
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HT Sample
C3
 
Organism Name: mouse, laboratory
Sex: Female
Age: postnatal week 22
Stage: 28
Structure . Name: islets of Langerhans
Curation Status: Curated
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Gene
345 | APOC3
Type: gene
Organism: human
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Publication
7964485 | J:21740
First Author: Cahen-Kramer Y
Year: 1994
Journal: J Exp Med
Title: The structure of an alternate form of complement C3 that displays costimulatory growth factor activity for B lymphocytes.
Volume: 180
Issue: 6
Pages: 2079-88
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Publication
12081998 | J:103349
First Author: Buono C
Year: 2002
Journal: Circulation
Title: Influence of C3 deficiency on atherosclerosis.
Volume: 105
Issue: 25
Pages: 3025-31
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Gene
4607 | MYBPC3
Type: gene
Organism: human
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Gene
3801 | KIFC3
Type: gene
Organism: human
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Gene
139081 | MAGEC3
Type: gene
Organism: human
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GXD Expression
GXD Expression
 
Probe: MGI:7531778
Assay Type: RNA in situ
Annotation Date: 2023-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Ubiquitous
Stage: TS28
Assay Id: MGI:7531805
Age: postnatal adult
Note: Uniform expression throughout liver hepatocytes.
Specimen Label: 7 C3 Antisense
Detected: true
Specimen Num: 6
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Publication
29018286 | J:255522
First Author: Peterson SL
Year: 2017
Journal: Sci Rep
Title: Complement Protein C3 Suppresses Axon Growth and Promotes Neuron Loss.
Volume: 7
Issue: 1
Pages: 12904
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Publication
22194859 | J:182250
First Author: Bauer EM
Year: 2011
Journal: PLoS One
Title: Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice.
Volume: 6
Issue: 12
Pages: e28578
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Publication
24260573 | J:209669
First Author: Ehrnthaller C
Year: 2013
Journal: PLoS One
Title: Complement C3 and C5 deficiency affects fracture healing.
Volume: 8
Issue: 11
Pages: e81341
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Publication
29867343 | J:265671
 
First Author: Gorelik A
Year: 2018
Journal: Front Mol Neurosci
Title: Complement C3 Affects Rac1 Activity in the Developing Brain.
Volume: 11
Pages: 150
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Publication
18160458 | J:133454
First Author: Paglialunga S
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice.
Volume: 294
Issue: 3
Pages: E521-9
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Publication
35250972 | J:324373
 
First Author: Wu X
Year: 2022
Journal: Front Immunol
Title: Reduced Neutrophil Extracellular Trap Formation During Ischemia Reperfusion Injury in C3 KO Mice: C3 Requirement for NETs Release.
Volume: 13
Pages: 781273
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Publication
6961437 | J:20069
First Author: Domdey H
Year: 1982
Journal: Proc Natl Acad Sci U S A
Title: Characterization of the mRNA and cloned cDNA specifying the third component of mouse complement.
Volume: 79
Issue: 24
Pages: 7619-23
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Publication
15870025 | J:105037
First Author: Welch TR
Year: 2005
Journal: Clin Immunol
Title: C3 is central to the interstitial component of experimental immune complex glomerulonephritis.
Volume: 115
Issue: 1
Pages: 80-4
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Publication
16778128 | J:123658
First Author: Mocco J
Year: 2006
Journal: Circ Res
Title: Complement component C3 mediates inflammatory injury following focal cerebral ischemia.
Volume: 99
Issue: 2
Pages: 209-17
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Publication
29746835 | J:264666
First Author: Sorbara MT
Year: 2018
Journal: Cell Host Microbe
Title: Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria.
Volume: 23
Issue: 5
Pages: 644-652.e5
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Publication
12244109 | J:80546
First Author: Xia Z
Year: 2002
Journal: J Biol Chem
Title: Acylation-stimulating protein (ASP) deficiency induces obesity resistance and increased energy expenditure in ob/ob mice.
Volume: 277
Issue: 48
Pages: 45874-9
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GXD Expression
GXD Expression
     
Probe: MGI:6728844
Assay Type: RT-PCR
Annotation Date: 2021-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6728883
Age: postnatal day 10
Specimen Label: C3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7711154
Assay Type: Western blot
Annotation Date: 2024-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691021
Stage: TS21
Assay Id: MGI:7711365
Age: embryonic day 13.5
Image: 4
Specimen Label: C3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:2681700
Assay Type: RT-PCR
Annotation Date: 2003-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Stage: TS26
Assay Id: MGI:2681733
Age: embryonic day 18.0
Specimen Label: c3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2681703
Assay Type: RT-PCR
Annotation Date: 2003-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Stage: TS26
Assay Id: MGI:2681765
Age: embryonic day 18.0
Specimen Label: C3
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:2681702
Assay Type: RT-PCR
Annotation Date: 2003-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757726
Stage: TS26
Assay Id: MGI:2681772
Age: embryonic day 18.0
Specimen Label: C3
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3056517
Assay Type: RT-PCR
Annotation Date: 2004-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3056537
Age: postnatal day 21
Specimen Label: C3
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:3056515
Assay Type: RT-PCR
Annotation Date: 2004-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3056539
Age: postnatal day 21
Specimen Label: C3
Detected: true
Specimen Num: 8
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Publication
32682912 | J:304007
First Author: Jackson WD
Year: 2021
Journal: J Invest Dermatol
Title: C3 Drives Inflammatory Skin Carcinogenesis Independently of C5.
Volume: 141
Issue: 2
Pages: 404-414.e6
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Publication
19581397 | J:152233
First Author: Tsoni SV
Year: 2009
Journal: Infect Immun
Title: Complement C3 plays an essential role in the control of opportunistic fungal infections.
Volume: 77
Issue: 9
Pages: 3679-85
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Publication
14607939 | J:119310
First Author: Verschoor A
Year: 2003
Journal: J Immunol
Title: Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection.
Volume: 171
Issue: 10
Pages: 5363-71
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Publication
34762761 | J:324318
First Author: Li Y
Year: 2021
Journal: FASEB J
Title: Intracellular C3 prevents hepatic steatosis by promoting autophagy and very-low-density lipoprotein secretion.
Volume: 35
Issue: 12
Pages: e22037
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Publication
1332870 | J:3378
First Author: Goldman MB
Year: 1992
Journal: Eur J Immunol
Title: T lymphocytes mediate immunologic control of C3 gene expression.
Volume: 22
Issue: 12
Pages: 3103-9
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Publication
34071589 | J:314509
 
First Author: Götz P
Year: 2021
Journal: Int J Mol Sci
Title: C3 Deficiency Leads to Increased Angiogenesis and Elevated Pro-Angiogenic Leukocyte Recruitment in Ischemic Muscle Tissue.
Volume: 22
Issue: 11
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Publication
34489939 | J:335344
 
First Author: Agostinis C
Year: 2021
Journal: Front Immunol
Title: The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis.
Volume: 12
Pages: 693118
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Publication
34673149 | J:329528
 
First Author: Bourel J
Year: 2021
Journal: Neurobiol Dis
Title: Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis.
Volume: 160
Pages: 105533
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Publication
28605809 | J:254679
First Author: Natoli R
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration.
Volume: 58
Issue: 7
Pages: 2977-2990
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Publication
16449793 | J:105786
First Author: Farrar CA
Year: 2006
Journal: FASEB J
Title: Local extravascular pool of C3 is a determinant of postischemic acute renal failure.
Volume: 20
Issue: 2
Pages: 217-26
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Publication
20800648 | J:166093
First Author: Guo Q
Year: 2010
Journal: Neurosci Lett
Title: Effects of C3 deficiency on inflammation and regeneration following spinal cord injury in mice.
Volume: 485
Issue: 1
Pages: 32-6
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Publication
18039928 | J:135262
First Author: Sheerin NS
Year: 2008
Journal: FASEB J
Title: Synthesis of complement protein C3 in the kidney is an important mediator of local tissue injury.
Volume: 22
Issue: 4
Pages: 1065-72
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Publication
27876407 | J:240044
First Author: Giacomassi C
Year: 2017
Journal: J Invest Dermatol
Title: Complement C3 Exacerbates Imiquimod-Induced Skin Inflammation and Psoriasiform Dermatitis.
Volume: 137
Issue: 3
Pages: 760-763
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Publication
33088172 | J:336612
 
First Author: Jiao H
Year: 2020
Journal: Mol Vis
Title: Ablation of C3 modulates macrophage reactivity in the outer retina during photo-oxidative damage.
Volume: 26
Pages: 679-690
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Publication
11433344 | J:70251
First Author: Springall T
Year: 2001
Journal: Nat Med
Title: Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli.
Volume: 7
Issue: 7
Pages: 801-6
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Publication
18587006 | J:140250
First Author: Flierl MA
Year: 2008
Journal: FASEB J
Title: Functions of the complement components C3 and C5 during sepsis.
Volume: 22
Issue: 10
Pages: 3483-90
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Publication
21408070 | J:171714
First Author: O'Brien KB
Year: 2011
Journal: PLoS One
Title: A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection.
Volume: 6
Issue: 3
Pages: e17377
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Publication
16517700 | J:129540
First Author: Peng Q
Year: 2006
Journal: J Immunol
Title: Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype.
Volume: 176
Issue: 6
Pages: 3330-41
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Publication
21767994 | J:177207
First Author: Gao X
Year: 2011
Journal: Clin Immunol
Title: Complement C3 deficiency prevent against the onset of streptozotocin-induced autoimmune diabetes involving expansion of regulatory T cells.
Volume: 140
Issue: 3
Pages: 236-43
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Publication
28566429 | J:249633
 
First Author: Shi Q
Year: 2017
Journal: Sci Transl Med
Title: Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.
Volume: 9
Issue: 392
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Publication
38035266 | J:343236
 
First Author: Schartz ND
Year: 2023
Journal: Front Mol Neurosci
Title: Mice deficient in complement C3 are protected against recognition memory deficits and astrogliosis induced by status epilepticus.
Volume: 16
Pages: 1265944
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Publication
21813769 | J:179122
First Author: Kenyon KD
Year: 2011
Journal: J Immunol
Title: IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity.
Volume: 187
Issue: 5
Pages: 2101-11
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Publication
12514742 | J:81697
First Author: Sohn JH
Year: 2003
Journal: Nat Med
Title: Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells.
Volume: 9
Issue: 2
Pages: 206-12
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Publication
9815267 | J:79296
First Author: Kopf M
Year: 1998
Journal: J Exp Med
Title: Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component.
Volume: 188
Issue: 10
Pages: 1895-906
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Publication
10408374 | J:56193
First Author: Circolo A
Year: 1999
Journal: Immunopharmacology
Title: Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA.
Volume: 42
Issue: 1-3
Pages: 135-49
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Publication
17433074 | J:125538
First Author: Coles B
Year: 2007
Journal: Immunology
Title: CD59 or C3 are not requred for angiotensin II-dependent hypertension or hypertrophy in mice.
Volume: 121
Issue: 4
Pages: 518-25
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Publication
101594 | J:6057
First Author: Natsuume-Sakai S
Year: 1978
Journal: J Immunol
Title: Preparation of an alloantiserum to murine C3 and demonstration of multiple alleles.
Volume: 121
Issue: 5
Pages: 2025-9
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Publication
21187447 | J:168910
First Author: Woods KM
Year: 2011
Journal: J Immunol
Title: CR2+ marginal zone B cell production of pathogenic natural antibodies is C3 independent.
Volume: 186
Issue: 3
Pages: 1755-62
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Publication
20584999 | J:169632
First Author: Lin M
Year: 2010
Journal: Diabetes
Title: Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin.
Volume: 59
Issue: 9
Pages: 2247-52
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Publication
37499656 | J:341063
First Author: Kiss MG
Year: 2023
Journal: Immunity
Title: Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis.
Volume: 56
Issue: 8
Pages: 1809-1824.e10
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Publication
31461345 | J:293381
First Author: Cui J
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Complement C3 exacerbates renal interstitial fibrosis by facilitating the M1 macrophage phenotype in a mouse model of unilateral ureteral obstruction.
Volume: 317
Issue: 5
Pages: F1171-F1182
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Publication
29716893 | J:276247
First Author: Müller-Calleja N
Year: 2018
Journal: Blood Adv
Title: Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies.
Volume: 2
Issue: 9
Pages: 979-986
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Publication
34543680 | J:336629
 
First Author: Westacott LJ
Year: 2022
Journal: Brain Behav Immun
Title: Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.
Volume: 99
Pages: 70-82
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Publication
15590640 | J:105051
First Author: Li J
Year: 2005
Journal: J Biol Chem
Title: Regulation of complement C3 expression by the bile acid receptor FXR.
Volume: 280
Issue: 9
Pages: 7427-34
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Publication
31955888 | J:296516
First Author: Shahini N
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling.
Volume: 523
Issue: 4
Pages: 867-873
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Publication
28446616 | J:242217
First Author: Harder JM
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.
Volume: 114
Issue: 19
Pages: E3839-E3848
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Publication
22438044 | J:183868
First Author: Fu H
Year: 2012
Journal: Glia
Title: Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia.
Volume: 60
Issue: 6
Pages: 993-1003
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Publication
458159 | J:6177
First Author: Natsuume-Sakai S
Year: 1979
Journal: J Immunol
Title: Genetic mapping of the locus controlling structural variations of murine C3 in the chromosome 17.
Volume: 123
Issue: 2
Pages: 947-8
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Publication
38618959 | J:348473
 
First Author: Jash A
Year: 2024
Journal: J Clin Invest
Title: Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice.
Volume: 134
Issue: 8
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Publication
30714990 | J:295266
First Author: Smith-Jackson K
Year: 2019
Journal: J Clin Invest
Title: Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice.
Volume: 129
Issue: 3
Pages: 1061-1075
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Publication
32733467 | J:308435
 
First Author: Anania JC
Year: 2020
Journal: Front Immunol
Title: IgG Suppresses Antibody Responses to Sheep Red Blood Cells in Double Knock-Out Mice Lacking Complement Factor C3 and Activating Fcγ-Receptors.
Volume: 11
Pages: 1404
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Publication
24842924 | J:319035
First Author: Yang Z
Year: 2014
Journal: Infect Immun
Title: Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum.
Volume: 82
Issue: 8
Pages: 3154-63
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Publication
21060153 | J:171870
First Author: Han R
Year: 2010
Journal: J Clin Invest
Title: Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice.
Volume: 120
Issue: 12
Pages: 4366-74
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Publication
6906228 | J:320299
First Author: Kerr MA
Year: 1980
Journal: Biochem J
Title: The human complement system: assembly of the classical pathway C3 convertase.
Volume: 189
Issue: 1
Pages: 173-81
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Publication
11509581 | J:71173
First Author: Verschoor A
Year: 2001
Journal: J Immunol
Title: Cutting edge: myeloid complement C3 enhances the humoral response to peripheral viral infection.
Volume: 167
Issue: 5
Pages: 2446-51
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Publication
16310250 | J:108114
First Author: Osmers I
Year: 2006
Journal: Mol Immunol
Title: Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated.
Volume: 43
Issue: 10
Pages: 1722-5
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Publication
11927943 | J:126202
First Author: Kopf M
Year: 2002
Journal: Nat Med
Title: Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.
Volume: 8
Issue: 4
Pages: 373-8
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Publication
18452991 | J:136225
First Author: Clark A
Year: 2008
Journal: Mol Immunol
Title: Evidence for non-traditional activation of complement factor C3 during murine liver regeneration.
Volume: 45
Issue: 11
Pages: 3125-32
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Publication
19729477 | J:153060
First Author: Leung VW
Year: 2009
Journal: Am J Pathol
Title: Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice.
Volume: 175
Issue: 4
Pages: 1757-67
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Publication
1590761 | J:1120
 
First Author: Kawamura N
Year: 1992
Journal: Biochem J
Title: Cis- and trans-acting elements required for constitutive and cytokine-regulated expression of the mouse complement C3 gene.
Volume: 283 ( Pt 3)
Pages: 705-12
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Publication
32244854 | J:301188
 
First Author: Klein AD
Year: 2020
Journal: Int J Mol Sci
Title: Complement Component C3 Participates in Early Stages of Niemann-Pick C Mouse Liver Damage.
Volume: 21
Issue: 6
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Publication
17353050 | J:120805
First Author: Szalai AJ
Year: 2007
Journal: Mol Immunol
Title: Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease.
Volume: 44
Issue: 12
Pages: 3132-6
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GXD Expression
GXD Expression
 
Probe: MGI:5473641
Assay Type: Immunohistochemistry
Annotation Date: 2013-04-10
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:1604611
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:5473685
Age: embryonic day 7.5
Note: No increased C3 deposition was noted in the trophectoderm.
Specimen Label: 1D
Detected: true
Specimen Num: 4
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Publication
30068650 | J:336578
 
First Author: Kim YJ
Year: 2018
Journal: J Virol
Title: Complement C3 Plays a Key Role in Inducing Humoral and Cellular Immune Responses to Influenza Virus Strain-Specific Hemagglutinin-Based or Cross-Protective M2 Extracellular Domain-Based Vaccination.
Volume: 92
Issue: 20
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Publication
23204401 | J:264171
First Author: Lesher AM
Year: 2013
Journal: J Am Soc Nephrol
Title: Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.
Volume: 24
Issue: 1
Pages: 53-65
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Publication
23747511 | J:198723
First Author: Hoh Kam J
Year: 2013
Journal: Am J Pathol
Title: Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration.
Volume: 183
Issue: 2
Pages: 480-92
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Publication
31076642 | J:287894
First Author: Zhong F
Year: 2019
Journal: Cell Res
Title: Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis.
Volume: 29
Issue: 7
Pages: 548-561
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Publication
16547268 | J:129872
First Author: Kerepesi LA
Year: 2006
Journal: J Immunol
Title: Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice.
Volume: 176
Issue: 7
Pages: 4315-22
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Publication
29565179 | J:264720
First Author: Okamoto T
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.
Volume: 315
Issue: 1
Pages: L1-L10
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Publication
24474777 | J:206648
First Author: Baudino L
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.
Volume: 111
Issue: 4
Pages: 1503-8
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Publication
19648268 | J:151871
First Author: Nakayama Y
Year: 2009
Journal: J Immunol
Title: C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection.
Volume: 183
Issue: 5
Pages: 2921-31
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Publication
24038599 | J:203114
First Author: Michel B
Year: 2013
Journal: Int Immunol
Title: Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease.
Volume: 25
Issue: 12
Pages: 697-702
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