RNA-binding protein 45 (RBM45), also known as Drb1, is a neural RNA-binding protein that forms cytoplasmic inclusions in neurons and glia in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) [, ]. It may function as a homo-oligomer and its oligomerization contributes to ALS/FTLD RNA-binding protein aggregation [].
This entry represents the RNA recognition motif 1 (RRM1) of RBM45, also termed developmentally-regulated RNA-binding protein 1 (DRB1), a member of RNA recognition motif (RRM)-type neural RNA-binding proteins, which is expressed under spatiotemporal control. It is encoded by gene drb1 that is expressed in neurons, not in glial cells. RBM45 predominantly localizes in the cytoplasm of cultured cells and specifically binds to poly(C) RNA. It could play an important role during neurogenesis []. RBM45 carries four RRMs.
This entry represents the RNA recognition motif 2 (RRM2) of RBM45, also termed developmentally-regulated RNA-binding protein 1 (DRB1), a member of RNA recognition motif (RRM)-type neural RNA-binding proteins, which is expressed under spatiotemporal control. It is encoded by gene drb1 that is expressed in neurons, not in glial cells. RBM45 predominantly localizes in the cytoplasm of cultured cells and specifically binds to poly(C) RNA. It could play an important role during neurogenesis []. RBM45 carries four RRMs.
This entry represents the RNA recognition motif3 (RRM3) of RBM45, also termed developmentally-regulated RNA-binding protein 1 (DRB1), a member of RNA recognition motif (RRM)-type neural RNA-binding proteins, which is expressed under spatiotemporal control. It is encoded by gene drb1 that is expressed in neurons, not in glial cells. RBM45 predominantly localizes in the cytoplasm of cultured cells and specifically binds to poly(C) RNA. It could play an important role during neurogenesis []. RBM45 carries four RRMs.
This entry represents the RNA recognition motif 4 (RRM4) of RBM45, also termed developmentally-regulated RNA-binding protein 1 (DRB1), a member of RNA recognition motif (RRM)-type neural RNA-binding proteins, which is expressed under spatiotemporal control. It is encoded by gene drb1 that is expressed in neurons, not in glial cells. RBM45 predominantly localizes in the cytoplasm of cultured cells and specifically binds to poly(C) RNA. It could play an important role during neurogenesis []. RBM45 carries four RRMs.
