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Search results 801 to 844 out of 844 for Lmx1a

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Type Details Score
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Protein
Q9JKU8
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: false
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HT Experiment
E-MTAB-5986 | RNA-Seq analysis of mouse dopamine neurons identifies transcriptional repression of PlexinC1 by Lmx1a and Lmx1b
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-45831 | EH004: Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/b-catenin signaling activator Rspo2
Series Id: GSE45831
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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GXD Expression
GXD Expression
Probe: MGI:7338964
Assay Type: Immunohistochemistry
Annotation Date: 2022-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7338981
Age: embryonic day 11.5
Image: 7M
Note: Complementary expression of Lmx1a and Dll1 was seen.
Specimen Label: 7M
Detected: true
Specimen Num: 8
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Allele
Tg(Lmx1a-cre)1Kjmi | MGI:4359769
Name: transgene insertion 1, Kathleen J Millen
Allele Type: Transgenic
Attribute String: Recombinase
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GXD Expression
GXD Expression
 
Probe: MGI:7595694
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595751
Age: embryonic day 14.5
Note: High expression adjacent to and co-localizing with the Lmx1a expression area and the TH-positive domain.
Specimen Label: 3B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7595694
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595751
Age: embryonic day 14.5
Note: High expression adjacent to and co-localizing with the Lmx1a expression area and the TH-positive domain.
Specimen Label: 3K
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:7595694
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595751
Age: embryonic day 14.5
Note: High expression adjacent to and co-localizing with the Lmx1a expression area and the TH-positive domain.
Specimen Label: 3T
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3843207
Assay Type: RNA in situ
Annotation Date: 2009-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3290020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3843214
Age: embryonic day 12.5
Note: Authors state that the domain of expression overlaps and falls within that of Lmx1a but outside that of Wnt1.
Specimen Label: 4A
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:7595697
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595755
Age: embryonic day 14.5
Note: High levels of expression in the ventricular and intermediate zone. Co-localised with TH and Lmx1a in the mesodiencephalic dopamine progenitor area.
Specimen Label: 3D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7595697
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595755
Age: embryonic day 14.5
Note: High levels of expression in the ventricular and intermediate zone. Co-localised with TH and Lmx1a in the mesodiencephalic dopamine progenitor area.
Specimen Label: 3M
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:7595697
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595755
Age: embryonic day 14.5
Note: High levels of expression in the ventricular and intermediate zone. Co-localised with TH and Lmx1a in the mesodiencephalic dopamine progenitor area.
Specimen Label: 3V
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:7432362
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3814217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7432371
Age: embryonic day 10.5
Image: S8B
Note: The medial limit of the expression domain in the cortical hem was indicated. The expression domain did not overlap with the Lmx1a domain significantly.
Specimen Label: S8B
Detected: true
Specimen Num: 1
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Allele
Tg(Lmx1a-EGFP/cre)3Kjmi | MGI:4461311
Name: transgene insertion 3, Kathleen J Millen
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
7974745 | -
First Author: Sánchez-García I
Year: 1994
Journal: Trends Genet
Title: The LIM domain: a new structural motif found in zinc-finger-like proteins.
Volume: 10
Issue: 9
Pages: 315-20
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Publication
10652534 | J:60218
First Author: Hobert O
Year: 2000
Journal: Trends Genet
Title: Functions of LIM-homeobox genes.
Volume: 16
Issue: 2
Pages: 75-83
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Publication
20082688 | -
 
First Author: Srivastava M
Year: 2010
Journal: BMC Biol
Title: Early evolution of the LIM homeobox gene family.
Volume: 8
Pages: 4
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Publication
15215291 | -
First Author: Chizhikov VV
Year: 2004
Journal: J Neurosci
Title: Control of roof plate development and signaling by Lmx1b in the caudal vertebrate CNS.
Volume: 24
Issue: 25
Pages: 5694-703
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Protein Domain
IPR042688 | Lmx1a_LIM1
Type: Domain
Description: This entry represents the first LIM domain of Lmx1a. Lmx1a belongs to the LHX protein family, which features two tandem N-terminal LIM domains and a C-terminal DNA binding homeodomain. Members of LHX family are found in the nucleus and act as transcription factors or cofactors []. LHX proteins are critical for the development of specialized cells in multiple tissue types, including the nervous system, skeletal muscle, the heart, the kidneys, and endocrine organs, such as the pituitary gland and the pancreas []. Mouse Lmx1a is expressed in multiple tissues, including the roof plate of the neural tube, the developing brain, the otic vesicles, the notochord, and the pancreas []. Human Lmx1a can be found in pancreas, skeletal muscle, adipose tissue, developing brain, mammary glands, and pituitary. The functions of Lmx1a in the developing nervous system were revealed by studies of mutant mouse. In mouse, mutations in Lmx1a result in failure of the roof plate to develop. Lmx1a may act upstream of other roof plate markers such as MafB, Gdf7, Bmp 6, and Bmp7. Further characterization of these mice reveals numerous defects including disorganized cerebellum, hippocampus, and cortex; altered pigmentation; female sterility; skeletal defects; and behavioural abnormalities [, , ]. Within pancreatic cells, the Lmx1a protein interacts synergistically with the bHLH transcription factor E47 to activate the insulin gene enhancer/promoter [].As in other LIM domains, this domain family is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein [].
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GXD Expression
GXD Expression
 
Probe: MGI:7595695
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595758
Age: embryonic day 14.5
Note: Expressed in a specific group of cells located adjacent to the mesodiencephalic dopamine neuronal system, most likely in the red nucleus area, and did not overlap with TH or Lmx1a expression domains.
Specimen Label: 3G
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7595695
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595758
Age: embryonic day 14.5
Note: Expressed in a specific group of cells located adjacent to the mesodiencephalic dopamine neuronal system, most likely in the red nucleus area, and did not overlap with TH or Lmx1a expression domains.
Specimen Label: 3P
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:7595695
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595758
Age: embryonic day 14.5
Note: Expressed in a specific group of cells located adjacent to the mesodiencephalic dopamine neuronal system, most likely in the red nucleus area, and did not overlap with TH or Lmx1a expression domains.
Specimen Label: 2N
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7595695
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7595758
Age: embryonic day 14.5
Note: Expressed in a specific group of cells located adjacent to the mesodiencephalic dopamine neuronal system, most likely in the red nucleus area, and did not overlap with TH or Lmx1a expression domains.
Specimen Label: 2R
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7432362
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3814217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7432371
Age: embryonic day 10.5
Image: S8E
Note: The medial limit of the expression domain in the cortical hem was indicated. In the mutant, the Lhx2 expression domain extended medially and included almost the entire cortical hem with significant overlap with the Lmx1a expression. domain.
Specimen Label: S8E
Detected: true
Specimen Num: 2
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Publication
14647207 | -
First Author: Matthews JM
Year: 2003
Journal: EMBO Rep
Title: LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins.
Volume: 4
Issue: 12
Pages: 1132-7
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Strain
MGI:7496030 | STOCK Tg(Lmx1a-EGFP/cre)3Kjmi/J
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Lmx1b/Lmx1b Tg(Lmx1a-cre)1Kjmi/?
Background: involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
28092268 | J:253288
   
First Author: Haldipur P
Year: 2017
Journal: Elife
Title: Phenotypic outcomes in Mouse and Human Foxc1 dependent Dandy-Walker cerebellar malformation suggest shared mechanisms.
Volume: 6
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Genotype
Genotype
Symbol: Lmx1a/Lmx1a Lmx1b/Lmx1b Tg(Lmx1a-cre)1Kjmi/?
Background: involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Lmx1a-EGFP/cre)3Kjmi/?
Background: involves: 129S4/SvJaeSor * CD-1
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Lmx1a-cre)1Kjmi/?
Background: involves: 129S1/SvImJ * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE58813 | Dickkopf 3 Promotes the Differentiation of Substantia Nigra Dopaminergic Neurons In Vivo and from Pluripotent Stem Cells In Vitro
Series Id: E-GEOD-58813
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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Protein
Q543W2
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: false
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Publication
35322202 | J:327070
First Author: Li Q
Year: 2022
Journal: Cell Death Differ
Title: Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.
Volume: 29
Issue: 8
Pages: 1596-1610
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Publication
26999738 | J:236644
First Author: Li L
Year: 2016
Journal: Nat Cell Biol
Title: Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.
Volume: 18
Issue: 4
Pages: 418-30
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lmx1a/Lmx1a Tg(Lmx1a-EGFP/cre)3Kjmi/?
Background: involves: 129S4/SvJaeSor * CD-1
Zygosity: cn
Has Mutant Allele: true
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Publication
28831020 | J:259567
 
First Author: Zhang D
Year: 2017
Journal: Sci Signal
Title: Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP.
Volume: 10
Issue: 493
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Publication
26755703 | J:311568
First Author: Klafke R
Year: 2016
Journal: Development
Title: Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development.
Volume: 143
Issue: 4
Pages: 691-702
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Publication
22173107 | J:191519
First Author: Hagan N
Year: 2012
Journal: Mol Cell Neurosci
Title: Wnt1 expression temporally allocates upper rhombic lip progenitors and defines their terminal cell fate in the cerebellum.
Volume: 49
Issue: 2
Pages: 217-29
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Publication
31668390 | J:292845
 
First Author: Piccand J
Year: 2019
Journal: Mol Metab
Title: Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production.
Volume: 29
Pages: 24-39
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