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Search results 101 to 194 out of 194 for Snx18

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_09
Specimen Label: euxassay_012165_09
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_10
Specimen Label: euxassay_012165_10
Detected: true
Specimen Num: 7
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_11
Specimen Label: euxassay_012165_11
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_12
Specimen Label: euxassay_012165_12
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_13
Specimen Label: euxassay_012165_13
Detected: true
Specimen Num: 10
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1832128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470687
Specimen Label: JAX_1470687
Detected: true
Specimen Num: 11
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_04
Specimen Label: euxassay_012165_04
Detected: true
Specimen Num: 1
•
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_05
Specimen Label: euxassay_012165_05
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_06
Specimen Label: euxassay_012165_06
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_07
Specimen Label: euxassay_012165_07
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_08
Specimen Label: euxassay_012165_08
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_15
Specimen Label: euxassay_012165_15
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_16
Specimen Label: euxassay_012165_16
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_17
Specimen Label: euxassay_012165_17
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_18
Specimen Label: euxassay_012165_18
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_19
Specimen Label: euxassay_012165_19
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_20
Specimen Label: euxassay_012165_20
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3271628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470721
Specimen Label: JAX_1470721
Detected: true
Specimen Num: 45
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470702
Specimen Label: JAX_1470702
Detected: true
Specimen Num: 26
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_06
Specimen Label: euxassay_012165_06
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470690
Specimen Label: JAX_1470690
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3590528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470685
Specimen Label: JAX_1470685
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1752528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470725
Specimen Label: JAX_1470725
Detected: true
Specimen Num: 49
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470696
Specimen Label: JAX_1470696
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424030
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828364
Age: embryonic day 14.5
Image: euxassay_012165_07
Specimen Label: euxassay_012165_07
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470704
Specimen Label: JAX_1470704
Detected: true
Specimen Num: 28
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3592628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470720
Specimen Label: JAX_1470720
Detected: true
Specimen Num: 44
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470714
Specimen Label: JAX_1470714
Detected: true
Specimen Num: 38
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470692
Specimen Label: JAX_1470692
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470694
Specimen Label: JAX_1470694
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470701
Specimen Label: JAX_1470701
Detected: true
Specimen Num: 25
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470698
Specimen Label: JAX_1470698
Detected: true
Specimen Num: 22
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692367
Age: postnatal adult
Image: JAX_1470705
Specimen Label: JAX_1470705
Detected: true
Specimen Num: 29
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Publication
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First Author: Cohn JB
Year: 2001
Journal: GenBank Submission
Title: Mus musculus SNAG1 (Snag1) mRNA, complete cds
Pages: AF408408
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Publication
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Journal: FEBS Lett
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Publication
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Publication
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First Author: Liu X
Year: 2016
Journal: BMC Immunol
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Volume: 17
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Publication
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First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
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First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
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First Author: Hansen J
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Journal: Proc Natl Acad Sci U S A
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Publication
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Publication
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Pages: D802-9
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Publication
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First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
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First Author: Cyagen Biosciences Inc.
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
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Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
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First Author: Hansen GM
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Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
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Publication
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First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Title: Nomenclature Committee Use
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Publication
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First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
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Year: 2003
Journal: Proc Natl Acad Sci U S A
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Publication
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
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Volume: 9
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
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First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
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First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
21969467 | -
First Author: Willenborg C
Year: 2011
Journal: J Cell Biol
Title: Interaction between FIP5 and SNX18 regulates epithelial lumen formation.
Volume: 195
Issue: 1
Pages: 71-86
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Allele
Snx18<em1Smoc> | MGI:7292508
Name: sorting nexin 18; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
14752159 | -
First Author: Yoo AS
Year: 2004
Journal: Science
Title: Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development.
Volume: 303
Issue: 5658
Pages: 663-6
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Publication
2271835 | -
First Author: DaCruz DJ
Year: 1990
Journal: BMJ
Title: Guidelines for management of asthma.
Volume: 301
Issue: 6763
Pages: 1276-7
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Protein Domain
IPR014536 | Snx9_fam
Type: Family
Description: Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 []. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module (), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis []. This entry also includes the sorting nexin lst-4 from Caenorhabditis elegans. It is involved in the signalling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling [].
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Protein Domain
IPR035557 | SNX18_SH3
Type: Domain
Description: Sorting nexin-18 (SNX18) is localized to peripheral endosomal structures, and acts in a trafficking pathway that is clathrin-independent but relies on AP-1 and PACS1 []. It binds FIP5 and is required for apical lumen formation []. It may also play a role in axonal elongation []. SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system [, ]. SNX18 also contains BAR and SH3 domains.This entry represent the SH3 domain of SNX18.
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Protein Domain
IPR028642 | SNX33
Type: Family
Description: Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have roles in cargo sorting through the endosomal netwrok []. Sorting nexins contain at least a PX domain (a phospholipid-binding motif). Some nexins contain a few additional domains. Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 []. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module (), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis []. This entry represents SNX33, which plays a role in maintaining cell shape and cell cycle progression through its interaction with WASp (Wiskott-Aldrich syndrome protein) []. It interferes with cellular prion protein (PrP) formation by modulation of its shedding []. It may also promote the formation of macropinosomes (large endocytic organelles) [].
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Protein Domain
IPR035703 | SNX18_PX
Type: Domain
Description: Sorting nexin-18 (SNX18) is localized to peripheral endosomal structures, and acts in a trafficking pathway that is clathrin-independent but relies on AP-1 and PACS1 []. It binds FIP5 and is required for apical lumen formation []. It may also play a role in axonal elongation []. SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system [, ]. SNX18 also contains BAR and SH3 domains.The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions. Sorting nexins (SNXs) make up the largest group among PX domain containing proteins. They are involved in regulating membrane traffic and protein sorting in the endosomal system. The PX domain of SNXs binds PIs and targets the protein to PI-enriched membranes [].
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Publication
19487689 | -
First Author: Zhang J
Year: 2009
Journal: J Biol Chem
Title: Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein.
Volume: 284
Issue: 32
Pages: 21659-69
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Publication
18419754 | -
First Author: Heiseke A
Year: 2008
Journal: Traffic
Title: The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding.
Volume: 9
Issue: 7
Pages: 1116-29
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Publication
21048941 | -
First Author: Wang JT
Year: 2010
Journal: PLoS One
Title: The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins.
Volume: 5
Issue: 10
Pages: e13763
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Protein Domain
IPR028644 | SNX9
Type: Family
Description: Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have roles in cargo sorting through the endosomal netwrok []. Sorting nexins contain at least a PX domain (a phospholipid-binding motif). Some nexins contain a few additional domains. Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 []. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module (), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis []. Sorting nexin 9 (SNX9) is a well-characterised member of this group; it is has been suggested to be involved in the endocytic process as an accessory factor []. SNX9 has binding sites for both clathrin and adaptor protein AP-2 in a low complexity region, and binds dynamin-2 (Dyn2) by its SH3 domain. SNX9 has its own membrane-binding activity, mediated by a carboxyl-terminal region containing the PX domain and the BAR domain []. Endogenous SNX9 partially co-localizes with AP-2 and Dyn2 at the plasma membrane, and over expression in K562 and HeLa cells of truncated versions of SNX9 inhibits the uptake of transferrin []. Moreover, SNX9 is required for efficient clathrin-mediated endocytosis, which suggests that it functions to regulate dynamin activity [].
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Protein Domain
IPR037427 | SNX33_BAR
Type: Domain
Description: Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have roles in cargo sorting through the endosomal netwrok []. Sorting nexins contain at least a PX domain (a phospholipid-binding motif). Some nexins contain a few additional domains. Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 []. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module (), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis []. SNX33 plays a role in maintaining cell shape and cell cycle progression through its interaction with WASp (Wiskott-Aldrich syndrome protein) []. It interferes with cellular prion protein (PrP) formation by modulation of its shedding []. It may also promote the formation of macropinosomes (large endocytic organelles) []. This entry represents the BAR domain of SNX33. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions [].
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Protein
Q4VAA7
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
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Publication
15703209 | -
First Author: Soulet F
Year: 2005
Journal: Mol Biol Cell
Title: SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.
Volume: 16
Issue: 4
Pages: 2058-67
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Publication
12952949 | -
First Author: Lundmark R
Year: 2003
Journal: J Biol Chem
Title: Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components.
Volume: 278
Issue: 47
Pages: 46772-81
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Publication
11879186 | -
First Author: Lundmark R
Year: 2002
Journal: Biochem J
Title: The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2.
Volume: 362
Issue: Pt 3
Pages: 597-607
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Protein
Q91VH2
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
Q3U1P2
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
Q3TZU7
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Publication
19379681 | -
First Author: Frost A
Year: 2009
Journal: Cell
Title: The BAR domain superfamily: membrane-molding macromolecules.
Volume: 137
Issue: 2
Pages: 191-6
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Protein
Q9CZK0
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: true
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Publication
16782399 | -
First Author: Seet LF
Year: 2006
Journal: Biochim Biophys Acta
Title: The Phox (PX) domain proteins and membrane traffic.
Volume: 1761
Issue: 8
Pages: 878-96
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