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Search results 601 to 665 out of 665 for Grm1

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Type Details Score
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
28886343 | -
First Author: Watson LM
Year: 2017
Journal: Am J Hum Genet
Title: Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.
Volume: 101
Issue: 3
Pages: 451-458
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DO Term
DOID:0080286 | spinocerebellar ataxia 44
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Allele
Grm1<crv4> | MGI:3664783
 
Name: glutamate receptor, metabotropic 1; cervelet 4
Allele Type: Spontaneous
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Allele
Grm1<em2Smoc> | MGI:7263412
Name: glutamate receptor, metabotropic 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Grm1/Grm1
Background: BALB/cPas-Grm1
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0080062 | autosomal recessive spinocerebellar ataxia 13
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Publication
25051141 | J:230115
 
First Author: Schiffner S
Year: 2014
Journal: Exp Eye Res
Title: Tg(Grm1) transgenic mice: a murine model that mimics spontaneous uveal melanoma in humans?
Volume: 127
Pages: 59-68
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Publication
31591386 | J:335289
First Author: de Jel MM
Year: 2019
Journal: Oncogenesis
Title: Loss of CYLD accelerates melanoma development and progression in the Tg(Grm1) melanoma mouse model.
Volume: 8
Issue: 10
Pages: 56
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Allele
Tg(Dct-Grm1)ESzc | MGI:3525118
Name: transgene insertion E, Suzie Chen
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(tetO-Grm1)7Atai | MGI:3715306
Name: transgene insertion 7, Atsu Aiba
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Strain
MGI:5803979 | C57BL/6J-Tg(Dct-Grm1)ESzc
Attribute String: transgenic, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Tg(Dct-Grm1)ESzc/?
Background: involves: C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Dct-Grm1)ESzc/?
Background: C57BL/6J-Tg(Dct-Grm1)ESzc
Zygosity: ot
Has Mutant Allele: true
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Publication
35293595 | J:335159
 
First Author: Schott M
Year: 2022
Journal: Int J Mol Med
Title: Impact of CYLD on chromatin structure and histone methylation in malignant melanoma.
Volume: 49
Issue: 5
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Publication
26121214 | J:226341
First Author: Mairhofer DG
Year: 2015
Journal: J Invest Dermatol
Title: Impaired gp100-Specific CD8(+) T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model.
Volume: 135
Issue: 11
Pages: 2785-2793
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Genotype
Genotype
Symbol: Grm1/Grm1 Pcp2/Pcp2<+> Tg(tetO-Grm1)7Atai/?
Background: involves: 129S2/SvPas * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
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Publication
36671524 | J:339543
 
First Author: Leembruggen AJL
Year: 2023
Journal: Biomolecules
Title: Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon.
Volume: 13
Issue: 1
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Publication
7476890 | -
First Author: Desai MA
Year: 1995
Journal: Mol Pharmacol
Title: Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.
Volume: 48
Issue: 4
Pages: 648-57
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Publication
24603153 | -
First Author: Wu H
Year: 2014
Journal: Science
Title: Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
Volume: 344
Issue: 6179
Pages: 58-64
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Protein Domain
IPR001256 | GPCR_3_mGluR1
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.mRNA for GRM1 is widespread in the brain and is abundant in neuronal cells in hippocampaldentate gyrus and CA2-3 regions, cerebellum Purkinje cells, olfactory bulband thalamic nuclei. GRM1 activates the phophoinositide pathway. It is thought to participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum [, ]. Like GRM5 [], it is a potential therapeutic target for several diseases []. Crystallisation of its seven transmembrane domain shows a similar structure to this seen in the entire GPCR protein family [].
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Publication
20055706 | -
 
First Author: Niswender CM
Year: 2010
Journal: Annu Rev Pharmacol Toxicol
Title: Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Volume: 50
Pages: 295-322
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Publication
34614413 | J:337048
First Author: Sharma MD
Year: 2021
Journal: Immunity
Title: Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity.
Volume: 54
Issue: 10
Pages: 2354-2371.e8
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Publication
7908515 | -
First Author: Minakami R
Year: 1994
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.
Volume: 199
Issue: 3
Pages: 1136-43
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Publication
25042998 | -
First Author: Doré AS
Year: 2014
Journal: Nature
Title: Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Volume: 511
Issue: 7511
Pages: 557-62
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Publication
34469715 | -
First Author: Nasrallah C
Year: 2021
Journal: Cell Rep
Title: Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.
Volume: 36
Issue: 9
Pages: 109648
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Protein Domain
IPR000202 | GPCR_3_mGluR5
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drugtargets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.mRNA for GRM5 is widespread in the brain, with a unique distribution; it is found in highlevels in the striatum, cerebral cortex, hippocampus and olfactory bulb.GRM5 activates the phosphoinositide pathway. It plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity []. Like GRM1 [], it is a potential therapeutic target for several diseases []with a similar structure to this seen in the entire GPCR superfamily [, ].
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Protein
Q8BJY3
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: true
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Publication
26601142 | J:259779
First Author: Sharma MD
Year: 2015
Journal: Sci Adv
Title: The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.
Volume: 1
Issue: 10
Pages: e1500845
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Publication
29343444 | J:272351
First Author: Sharma MD
Year: 2018
Journal: Immunity
Title: Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors.
Volume: 48
Issue: 1
Pages: 91-106.e6
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Publication
1320017 | -
First Author: Abe T
Year: 1992
Journal: J Biol Chem
Title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.
Volume: 267
Issue: 19
Pages: 13361-8
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Publication
1847995 | -
First Author: Masu M
Year: 1991
Journal: Nature
Title: Sequence and expression of a metabotropic glutamate receptor.
Volume: 349
Issue: 6312
Pages: 760-5
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Publication
1656524 | -
First Author: Houamed KM
Year: 1991
Journal: Science
Title: Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain.
Volume: 252
Issue: 5010
Pages: 1318-21
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Protein
P97772
Organism: Mus musculus/domesticus
Length: 1199  
Fragment?: false
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Protein
Q3V0U2
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: true
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Publication
10773016 | -
First Author: Sullivan R
Year: 2000
Journal: J Pharmacol Exp Ther
Title: Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.
Volume: 293
Issue: 2
Pages: 460-7
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Publication
9292726 | J:42626
First Author: Ryba NJ
Year: 1997
Journal: Neuron
Title: A new multigene family of putative pheromone receptors.
Volume: 19
Issue: 2
Pages: 371-9
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Publication
17266540 | -
First Author: Bräuner-Osborne H
Year: 2007
Journal: Curr Drug Targets
Title: Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Volume: 8
Issue: 1
Pages: 169-84
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Publication
8255296 | -
First Author: Brown EM
Year: 1993
Journal: Nature
Title: Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.
Volume: 366
Issue: 6455
Pages: 575-80
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Publication
1309649 | -
First Author: Tanabe Y
Year: 1992
Journal: Neuron
Title: A family of metabotropic glutamate receptors.
Volume: 8
Issue: 1
Pages: 169-79
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Protein
Q3UVX5
Organism: Mus musculus/domesticus
Length: 1203  
Fragment?: false
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Protein
E9QMC2
Organism: Mus musculus/domesticus
Length: 1171  
Fragment?: false
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Protein
B7ZMP7
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
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Protein
Q4VA56
Organism: Mus musculus/domesticus
Length: 1065  
Fragment?: true
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Protein
B2BH30
Organism: Mus musculus/domesticus
Length: 1203  
Fragment?: false
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Publication
12679517 | J:83410
First Author: Vassilatis DK
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: The G protein-coupled receptor repertoires of human and mouse.
Volume: 100
Issue: 8
Pages: 4903-8
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Publication
8170923 | -
First Author: Attwood TK
Year: 1994
Journal: Protein Eng
Title: Fingerprinting G-protein-coupled receptors.
Volume: 7
Issue: 2
Pages: 195-203
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Publication
8081729 | -
First Author: Kolakowski LF Jr
Year: 1994
Journal: Receptors Channels
Title: GCRDb: a G-protein-coupled receptor database.
Volume: 2
Issue: 1
Pages: 1-7
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Publication
15914470 | -
First Author: Foord SM
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume: 57
Issue: 2
Pages: 279-88
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Publication
18948278 | -
First Author: Harmar AJ
Year: 2009
Journal: Nucleic Acids Res
Title: IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume: 37
Issue: Database issue
Pages: D680-5
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Publication
16753280 | J:115055
First Author: Bjarnadóttir TK
Year: 2006
Journal: Genomics
Title: Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Volume: 88
Issue: 3
Pages: 263-73
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Publication
23020293 | -
 
First Author: Civelli O
Year: 2013
Journal: Annu Rev Pharmacol Toxicol
Title: G protein-coupled receptor deorphanizations.
Volume: 53
Pages: 127-46
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom