Type |
Details |
Score |
Allele |
Name: |
NOP2 nucleolar protein; gene trap 320H4, Centre for Modeling Human Disease |
Allele Type: |
Gene trapped |
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•
•
•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Allele |
Name: |
NOP2 nucleolar protein; gene trap IST13520C8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
NOP2 nucleolar protein; gene trap IST14073H9, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
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•
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Genotype |
Symbol: |
Nop2/Nop2 |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
793
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
794
|
Fragment?: |
false |
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•
•
•
•
•
|
Publication |
First Author: |
Tscherne JS |
Year: |
1999 |
Journal: |
Biochemistry |
Title: |
Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli. |
Volume: |
38 |
Issue: |
6 |
Pages: |
1884-92 |
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•
•
•
•
•
|
Publication |
First Author: |
Reid R |
Year: |
1999 |
Journal: |
Nucleic Acids Res |
Title: |
Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences. |
Volume: |
27 |
Issue: |
15 |
Pages: |
3138-45 |
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•
•
•
•
•
|
Publication |
First Author: |
King MY |
Year: |
2002 |
Journal: |
Biochemistry |
Title: |
RNA methyltransferases utilize two cysteine residues in the formation of 5-methylcytosine. |
Volume: |
41 |
Issue: |
37 |
Pages: |
11218-25 |
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•
•
•
•
•
|
Publication |
First Author: |
Pavlopoulou A |
Year: |
2009 |
Journal: |
Genomics |
Title: |
Phylogenetic analysis of the eukaryotic RNA (cytosine-5)-methyltransferases. |
Volume: |
93 |
Issue: |
4 |
Pages: |
350-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Motorin Y |
Year: |
2010 |
Journal: |
Nucleic Acids Res |
Title: |
5-methylcytosine in RNA: detection, enzymatic formation and biological functions. |
Volume: |
38 |
Issue: |
5 |
Pages: |
1415-30 |
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•
•
•
•
•
|
Publication |
First Author: |
Gu XR |
Year: |
1999 |
Journal: |
Biochemistry |
Title: |
Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli. |
Volume: |
38 |
Issue: |
13 |
Pages: |
4053-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Bujnicki JM |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
Sequence-structure-function studies of tRNA:m5C methyltransferase Trm4p and its relationship to DNA:m5C and RNA:m5U methyltransferases. |
Volume: |
32 |
Issue: |
8 |
Pages: |
2453-63 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Repeat |
Description: |
This characteristic repeat of proliferating cell nuclear antigen P120 is found in three copies []. This repeat can be found in the human NOP2 protein, a probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase. |
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•
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Publication |
First Author: |
Hikida Y |
Year: |
2010 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
Structure of an archaeal homologue of the bacterial Fmu/RsmB/RrmB rRNA cytosine 5-methyltransferase. |
Volume: |
66 |
Issue: |
Pt 12 |
Pages: |
1301-7 |
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Protein Domain |
Type: |
Domain |
Description: |
The C-terminal catalytic domain of ribosomal RNA cysteine methyltransferases is highly conserved in archaeal, bacterial and eukaryotic proteins [], such as ribosomal RNA methyltransferase B (RsmB, Sun, Fmu) and Nop2. Escherichia coli RsmB methylates cytosine C967 in 16S rRNA []. Nop2 methylates cytosine C2870 in the 25S rRNA of S. cerevisiae []and is critical for 60S biogenesis []. |
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HT Experiment |
Series Id: |
GSE57824 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
ArrayExpress |
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•
•
•
•
•
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Publication |
First Author: |
Schubert HL |
Year: |
2003 |
Journal: |
Trends Biochem Sci |
Title: |
Many paths to methyltransfer: a chronicle of convergence. |
Volume: |
28 |
Issue: |
6 |
Pages: |
329-35 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
724
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
705
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
700
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hong B |
Year: |
1997 |
Journal: |
Mol Cell Biol |
Title: |
Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast. |
Volume: |
17 |
Issue: |
1 |
Pages: |
378-88 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
465
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
381
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
348
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
476
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
757
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
425
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
782
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
722
|
Fragment?: |
false |
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•
•
•
•
•
|
Publication |
First Author: |
Staub E |
Year: |
2004 |
Journal: |
Bioessays |
Title: |
Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. |
Volume: |
26 |
Issue: |
5 |
Pages: |
567-81 |
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•
•
•
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•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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