A-kinase anchor protein 9 (AKAP9, also known as AKAP 350) and pericentrin (pericentrin-B, kendrin) are large coiled-coil proteins found in mammalian centrosomes that serve to recruit structural and regulatory components including dynein and protein kinase [, ]. These scaffold proteins contain a pericentrin-AKAP-450 centrosomal targeting (PACT) domain [].Mutations of AKAP9 cause long QT syndrome 11 (LQT11), which is a heart disorder characterised by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias []. AKAP9 has also been implicated in breast cancer []and sporadic papillary thyroid carcinomas []. In mice, AKAP9 is essential for Spermatogenesis and sertoli cell maturation [].
Cep72 is a centrosomal protein that interacts with Kizuna and plays an important role in maintaining microtubule-organizing activity and structural integrity of the centrosome. It is required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) []and for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization [].
