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Search results 101 to 136 out of 136 for Pan2

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Type Details Score
Allele
Pan2<Gt(350D1)Cmhd> | MGI:4952194
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap 350D1, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Strain
MGI:5566630 | C57BL/6NCrlAnu-Pan2<m1Anu>
Attribute String: coisogenic, chemically induced mutation, mutant strain
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Strain
MGI:5564678 | C57BL/6NCrlAnu-Pan2<m1Anu>/AnuApb
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Allele
Pan2<Gt(PST18019)Mfgc> | MGI:3901770
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap PST18019, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Pan2<Gt(IST14536H1)Tigm> | MGI:5240427
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap IST14536H1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Pan2<tm1b(KOMP)Wtsi> | MGI:5605785
Name: PAN2 poly(A) specific ribonuclease subunit; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Pan2<Gt(PST7139)Mfgc> | MGI:4343040
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap PST7139, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Pan2<Gt(XT0188)Wtsi> | MGI:3867175
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap XT0188, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Pan2<tm1a(KOMP)Wtsi> | MGI:5014572
Name: PAN2 poly(A) specific ribonuclease subunit; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Pan2<Gt(PST25182)Mfgc> | MGI:3904662
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap PST25182, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Pan2<Gt(IST12491A11)Tigm> | MGI:4071844
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap IST12491A11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Genotype
Genotype
Symbol: Pan2/Pan2
Background: C57BL/6NCrlAnu-Pan2
Zygosity: hm
Has Mutant Allele: true
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Publication
23932717 | -
First Author: Christie M
Year: 2013
Journal: Mol Cell
Title: Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins.
Volume: 51
Issue: 3
Pages: 360-73
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Protein Coding Gene
MGI:1920402 | Rdh14
Type: protein_coding_gene
Organism: mouse, laboratory
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Strain
MGI:6771906 | C57BL/6N-Pan2<tm1b(KOMP)Wtsi>/Mhzh
Attribute String: coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Pan2/Pan2
Background: C57BL/6N-Pan2/Mhzh
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:98510 | Tcf3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21078877 | -
First Author: Clement SL
Year: 2011
Journal: Mol Cell Biol
Title: Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.
Volume: 31
Issue: 2
Pages: 256-66
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Protein
A0A0J9YV55
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
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Protein
H3BJ17
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
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Publication
24880344 | -
First Author: Schäfer IB
Year: 2014
Journal: Nat Struct Mol Biol
Title: The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase.
Volume: 21
Issue: 7
Pages: 591-8
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Publication
17595167 | -
First Author: Siddiqui N
Year: 2007
Journal: J Biol Chem
Title: Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein.
Volume: 282
Issue: 34
Pages: 25067-75
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Protein Domain
IPR028881 | PAN2_UCH_dom
Type: Domain
Description: The poly(A)-specific nuclease (PAN) is a deadenylating enzyme involved in cytoplasmic mRNA turnover and consists of two subunits, PAN2 and PAN3, which form a conserved complex acting in the initial trimming of poly(A) tails, a process followed by the processive action of CCR4-NOT complex. PAN2 is the catalytic subunit and has two independent structural units, the N-terminal assembly unit which engages in a bipartite interaction with PAN3 dimers and the C-terminal catalytic unit [, , ]. The C-terminal unit contains the ubiquitin C-terminal hydrolase (UCH) domain, represented in this entry, and a RNase domain of the DEDD superfamily () [, ].
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Protein Domain
IPR030844 | PAN3
Type: Family
Description: Pan3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of the two eukaryotic poly(A) nuclease complexes (Ccr4-Caf1 and Pan2-Pan3) involved in mRNA decay [, ]. It contains a PABP-interacting motif 2 (PAM2) that binds to the C-terminal domain of polyA binding proteins (PABPs) []. It recruits the Pan2-Pan3 complex to mRNA through the Pan3-PABP interaction [].Regulation of mRNA decay rates in eukaryotic cells affects gene expression []. The Pan2-Pan3 complex shortens cytoplasmic mRNA 3' polyA tails to regulate mRNA stability []. In the complex Pan2 provides the catalytic activity, whereas Pan3 mediates Pan2 recruitment to mRNA targets [].
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Protein
H3BJA8
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Publication
15044470 | J:90734
First Author: Viswanathan P
Year: 2004
Journal: J Biol Chem
Title: Mouse CAF1 can function as a processive deadenylase/3'-5'-exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly(A) removal.
Volume: 279
Issue: 23
Pages: 23988-95
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Publication
26134871 | J:224533
First Author: Ma J
Year: 2015
Journal: Biol Reprod
Title: Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation.
Volume: 93
Issue: 2
Pages: 48
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Protein
Q5U221
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
H3BLB9
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: true
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Protein
Q80XN5
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
H3BJH6
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: true
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Protein
Q640Q5
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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Protein
H3BKF3
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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