This entry represents a group of thioredoxin domain-containing proteins, including TXNDC17 from animals, SPBC21C3.12c from fission yeasts and AtClot from Arabidopsis. TXNDC17, also known as TRP14, is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways. TXNDC17 has been shown to efficiently reduce l-cystine and can directly reactivate oxidized protein-tyrosine phosphatase PTP1B [].
This domain can be found in thioredoxin domain-containing protein 17 (also known as TRP14), which is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways. TXNDC17 has been shown to efficiently reduce l-cystine and can directly reactivate oxidized protein-tyrosine phosphatase PTP1B [].
