|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 650 out of 650 for Unc5c

<< First    < Previous  |  Next >    Last >>
0.023s
Type Details Score
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 950  
Fragment?: false
GXD Expression  
Probe: MGI:4830304
Assay Type: In situ reporter (knock in)
Annotation Date: 2018-12-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6258913
Age: embryonic day 15.5
Note: There was no colocalization with Unc5c staining.
Specimen Label: 5e
Detected: true
Specimen Num: 2
Publication
First Author: Tong J
Year: 2001
Journal: J Biol Chem
Title: Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.
Volume: 276
Issue: 44
Pages: 40917-25
Publication
First Author: Hibi K
Year: 2009
Journal: Anticancer Res
Title: Changes in UNC5C gene methylation during human gastric carcinogenesis.
Volume: 29
Issue: 11
Pages: 4397-9
Allele
Name: unc-5 netrin receptor C; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: unc-5 netrin receptor C; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele  
Name: unc-5 netrin receptor C; transgene insertion 5, Han-Woong Lee
Allele Type: Transgenic
Allele  
Name: unc-5 netrin receptor C; rostral cerebellar malformation (Tg(Ucp)1.23Kz)
Allele Type: Transgenic
Protein Domain
Type: Domain
Description: This entry represents the death domain (DD) found in Uncoordinated-5C (UNC5C), which is a receptor for the secreted netrin-1 and plays a role in axonal guidance, angiogenesis, and apoptosis. It belongs to the UNC-5 family. UNC5C plays a critical role in the development of spinal accessory motor neurons []. Methylation of the UNC5C gene is associated with early stages of colorectal carcinogenesis [, ].UNC5 proteins are transmembrane proteins with an extracellular domain consisting of two immunoglobulin repeats, two thrombospondin type-I modules and an intracellular region containing a ZU-5 domain, UPA domain and a DD [, , ].DDs (Death domains) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [, ].
Publication
First Author: O'Sullivan ML
Year: 2012
Journal: Neuron
Title: FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development.
Volume: 73
Issue: 5
Pages: 903-10
Allele  
Name: fibronectin leucine rich transmembrane protein 2; endonuclease-mediated mutation 1, Jeremy Kay
Allele Type: Endonuclease-mediated
Strain
Attribute String: transgenic, mutant strain, congenic
Genotype
Symbol: Unc5c/Unc5c
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Unc5c/Unc5c
Background: involves: C57BL/6J * SJL/J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Unc5c/Unc5c
Background: B6.Cg-Unc5c
Zygosity: hm
Has Mutant Allele: true
Strain
Attribute String: congenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Dcc/Dcc<+> Unc5c/Unc5c<+>
Background: involves: 129X1/SvJ * C57BL/6J * SJL/J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Dcc/Dcc<+> Unc5c/Unc5c
Background: involves: 129X1/SvJ * C57BL/6J * SJL/J
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Heiliger KJ
Year: 2012
Journal: Endocr Relat Cancer
Title: Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice.
Volume: 19
Issue: 3
Pages: 409-21
Publication
First Author: Leonardo ED
Year: 1997
Journal: Nature
Title: Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors.
Volume: 386
Issue: 6627
Pages: 833-8
Publication
First Author: Rajasekharan S
Year: 2009
Journal: Genome Biol
Title: The netrin protein family.
Volume: 10
Issue: 9
Pages: 239
Publication
First Author: Shao A
Year: 2022
Journal: Sci Rep
Title: Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney.
Volume: 12
Issue: 1
Pages: 17586
Protein
Organism: Mus musculus/domesticus
Length: 950  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 950  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 876  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 876  
Fragment?: false
Publication
First Author: Feinstein E
Year: 1995
Journal: Trends Biochem Sci
Title: The death domain: a module shared by proteins with diverse cellular functions.
Volume: 20
Issue: 9
Pages: 342-4
Publication  
First Author: Park HH
Year: 2007
Journal: Annu Rev Immunol
Title: The death domain superfamily in intracellular signaling of apoptosis and inflammation.
Volume: 25
Pages: 561-86
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89