Type |
Details |
Score |
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
931
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
950
|
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4830304 |
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2018-12-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270323 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:6258913 |
Age: |
embryonic day 15.5 |
|
Note: |
There was no colocalization with Unc5c staining. |
Specimen Label: |
5e |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tong J |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain. |
Volume: |
276 |
Issue: |
44 |
Pages: |
40917-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hibi K |
Year: |
2009 |
Journal: |
Anticancer Res |
Title: |
Changes in UNC5C gene methylation during human gastric carcinogenesis. |
Volume: |
29 |
Issue: |
11 |
Pages: |
4397-9 |
|
•
•
•
•
•
|
Allele |
Name: |
unc-5 netrin receptor C; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
unc-5 netrin receptor C; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
unc-5 netrin receptor C; transgene insertion 5, Han-Woong Lee |
Allele Type: |
Transgenic |
|
|
•
•
•
•
•
|
Allele |
Name: |
unc-5 netrin receptor C; rostral cerebellar malformation (Tg(Ucp)1.23Kz) |
Allele Type: |
Transgenic |
|
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the death domain (DD) found in Uncoordinated-5C (UNC5C), which is a receptor for the secreted netrin-1 and plays a role in axonal guidance, angiogenesis, and apoptosis. It belongs to the UNC-5 family. UNC5C plays a critical role in the development of spinal accessory motor neurons []. Methylation of the UNC5C gene is associated with early stages of colorectal carcinogenesis [, ].UNC5 proteins are transmembrane proteins with an extracellular domain consisting of two immunoglobulin repeats, two thrombospondin type-I modules and an intracellular region containing a ZU-5 domain, UPA domain and a DD [, , ].DDs (Death domains) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Sullivan ML |
Year: |
2012 |
Journal: |
Neuron |
Title: |
FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. |
Volume: |
73 |
Issue: |
5 |
Pages: |
903-10 |
|
•
•
•
•
•
|
Allele |
Name: |
fibronectin leucine rich transmembrane protein 2; endonuclease-mediated mutation 1, Jeremy Kay |
Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Unc5c/Unc5c |
Background: |
involves: FVB/N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Unc5c/Unc5c |
Background: |
involves: C57BL/6J * SJL/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Unc5c/Unc5c |
Background: |
B6.Cg-Unc5c |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dcc/Dcc<+> Unc5c/Unc5c<+> |
Background: |
involves: 129X1/SvJ * C57BL/6J * SJL/J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dcc/Dcc<+> Unc5c/Unc5c |
Background: |
involves: 129X1/SvJ * C57BL/6J * SJL/J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Heiliger KJ |
Year: |
2012 |
Journal: |
Endocr Relat Cancer |
Title: |
Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice. |
Volume: |
19 |
Issue: |
3 |
Pages: |
409-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leonardo ED |
Year: |
1997 |
Journal: |
Nature |
Title: |
Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. |
Volume: |
386 |
Issue: |
6627 |
Pages: |
833-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajasekharan S |
Year: |
2009 |
Journal: |
Genome Biol |
Title: |
The netrin protein family. |
Volume: |
10 |
Issue: |
9 |
Pages: |
239 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shao A |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney. |
Volume: |
12 |
Issue: |
1 |
Pages: |
17586 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
950
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
950
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
876
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
876
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Feinstein E |
Year: |
1995 |
Journal: |
Trends Biochem Sci |
Title: |
The death domain: a module shared by proteins with diverse cellular functions. |
Volume: |
20 |
Issue: |
9 |
Pages: |
342-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park HH |
Year: |
2007 |
Journal: |
Annu Rev Immunol |
Title: |
The death domain superfamily in intracellular signaling of apoptosis and inflammation. |
Volume: |
25 |
|
Pages: |
561-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|