CDK5RAP3 (also known as C53 or LZAP) serves as a probable tumour suppressor initially identified as a CDK5R1 interactor controllingcell proliferation [, ]. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation [, ]. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint [, ]. It has been shown to bind Wip1 and stimulates its phosphatase activity [].
