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Search results 1 to 78 out of 78 for Arpc5

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
10092 | ARPC5
Type: gene
Organism: human
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Gene
549996 | arpc5
Type: gene
Organism: frog, western clawed
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Gene
360854 | Arpc5
Type: gene
Organism: rat
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Gene
480037 | ARPC5
Type: gene
Organism: dog, domestic
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Gene
457574 | ARPC5
Type: gene
Organism: chimpanzee
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Gene
614345 | ARPC5
Type: gene
Organism: cattle
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Gene
429075 | ARPC5
Type: gene
Organism: chicken
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Gene
714896 | ARPC5
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1915021 | Arpc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR006789 | ARPC5
Type: Family
Description: Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures []. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family protein []. Arp2 and Arp3 are thought to be brought together after activation, forming an actin-like nucleus for actin monomers to bind and create a new actin filament. In the absence of an activating protein, Arp2/3 shows very little nucleation activity. Recent research has focused on the binding and hydrolysis of ATP by Arp2 and Arp3 [], and crystal structures of the Arp2/3 complex have been solved [].The human Arp2/3 complex consists of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. This family represents the ARPC5/p16-ARC subunit.
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Publication
37382373 | J:334465
 
First Author: Sindram E
Year: 2023
Journal: Dis Model Mech
Title: ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality.
Volume: 16
Issue: 7
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Publication
22447776 | J:183553
First Author: Chang YF
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation.
Volume: 109
Issue: 15
Pages: 5750-5
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GXD Expression
GXD Expression
 
Probe: MGI:2463539
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354801
Age: embryonic day 14.5
Note: Expression is present in the upper and lower cortical plate.
Specimen Label: Table S5 - Arpc5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2463539
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354801
Age: embryonic day 14.5
Specimen Label: Table S5 - Arpc5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2463539
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754722
Stage: TS22
Assay Id: MGI:4354801
Age: embryonic day 14.5
Specimen Label: Table S5 - Arpc5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6198383
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:7518231
Age: embryonic day 9.5
Image: 6D Arpc5 KO
Specimen Label: 6D Arpc5 KO
Detected: true
Specimen Num: 2
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Protein
Q9D898
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
Q9CPW4
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
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Protein
Q3UA72
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
Q3UC32
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
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Protein
Q3TK56
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Protein
Q3TKM9
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
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Protein
A0A0R3P9C9
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: false
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Publication
9889097 | -
First Author: Machesky LM
Year: 1998
Journal: Curr Biol
Title: Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.
Volume: 8
Issue: 25
Pages: 1347-56
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Publication
15505213 | -
First Author: Nolen BJ
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.
Volume: 101
Issue: 44
Pages: 15627-32
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Publication
9600938 | -
First Author: Mullins RD
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments.
Volume: 95
Issue: 11
Pages: 6181-6
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Publication
11752435 | -
First Author: Dayel MJ
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments.
Volume: 98
Issue: 26
Pages: 14871-6
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Protein Coding Gene
MGP_CAROLIEiJ_G0014702 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016572 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016537 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016532 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016357 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1915021 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015936 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016331 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016437 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016435 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016461 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017029 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015722 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027938 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015509 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15294161 | J:91946
First Author: Mejillano MR
Year: 2004
Journal: Cell
Title: Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end.
Volume: 118
Issue: 3
Pages: 363-73
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Publication
12473693 | J:80756
First Author: DeMali KA
Year: 2002
Journal: J Cell Biol
Title: Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion.
Volume: 159
Issue: 5
Pages: 881-91
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Publication
19521500 | J:149737
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
21281821 | J:169072
First Author: Silverman-Gavrila R
Year: 2011
Journal: Am J Pathol
Title: Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKCα, ARPC5, and RHAMM.
Volume: 178
Issue: 2
Pages: 895-910
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