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Search results 2501 to 2600 out of 2736 for Psen1

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Type Details Score
Publication
15223380 | J:102407
First Author: Todd Roach J
Year: 2004
Journal: Brain Res
Title: Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice.
Volume: 1015
Issue: 1-2
Pages: 161-8
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Publication
18596919 | J:140891
First Author: Trinchese F
Year: 2008
Journal: J Clin Invest
Title: Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.
Volume: 118
Issue: 8
Pages: 2796-807
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Publication
11140686 | J:66407
First Author: Morgan D
Year: 2000
Journal: Nature
Title: A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.
Volume: 408
Issue: 6815
Pages: 982-5
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Publication
22042871 | J:180222
First Author: Kiyota T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders.
Volume: 108
Issue: 49
Pages: E1339-48
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Publication
13678662 | J:126842
First Author: Lemere CA
Year: 2003
Journal: Neurobiol Dis
Title: Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.
Volume: 14
Issue: 1
Pages: 10-8
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Publication
17714960 | J:128849
First Author: Cracchiolo JR
Year: 2007
Journal: Neurobiol Learn Mem
Title: Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity.
Volume: 88
Issue: 3
Pages: 277-94
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Publication
20471717 | J:188241
First Author: Lee HJ
Year: 2012
Journal: Neurobiol Aging
Title: Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.
Volume: 33
Issue: 3
Pages: 588-602
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Publication
17434239 | J:140914
First Author: Oberg J
Year: 2008
Journal: Neurobiol Aging
Title: Age related changes in brain metabolites observed by 1H MRS in APP/PS1 mice.
Volume: 29
Issue: 9
Pages: 1423-33
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Publication
15993985 | J:111750
First Author: Ewers M
Year: 2006
Journal: Neurobiol Aging
Title: Associative and motor learning in 12-month-old transgenic APP+PS1 mice.
Volume: 27
Issue: 8
Pages: 1118-28
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Publication
15689237 | J:96659
 
First Author: Dickey CA
Year: 2005
Journal: BMC Neurosci
Title: Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice.
Volume: 6
Pages: 7
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Publication
20371618 | J:162341
First Author: Kiyota T
Year: 2010
Journal: FASEB J
Title: CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice.
Volume: 24
Issue: 8
Pages: 3093-102
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Publication
22595040 | J:190488
First Author: Wang H
Year: 2012
Journal: Behav Brain Res
Title: Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer's disease.
Volume: 233
Issue: 1
Pages: 237-43
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Publication
26010758 | J:237744
First Author: Verma M
Year: 2015
Journal: PLoS One
Title: Chronic Anatabine Treatment Reduces Alzheimer's Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD.
Volume: 10
Issue: 5
Pages: e0128224
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Publication
15215182 | J:135057
First Author: Kowa H
Year: 2004
Journal: Am J Pathol
Title: Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
Volume: 165
Issue: 1
Pages: 273-81
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Publication
22440674 | J:191255
First Author: Yu D
Year: 2012
Journal: Neurobiol Aging
Title: Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease.
Volume: 33
Issue: 12
Pages: 2942-7
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Publication
11164808 | J:128650
First Author: Arendash GW
Year: 2001
Journal: Brain Res
Title: Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.
Volume: 891
Issue: 1-2
Pages: 42-53
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Publication
19805389 | J:153208
First Author: Smith DL
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Reversal of long-term dendritic spine alterations in Alzheimer disease models.
Volume: 106
Issue: 39
Pages: 16877-82
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Publication
20451607 | J:164930
First Author: Braithwaite SP
Year: 2010
Journal: Neurobiol Dis
Title: Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.
Volume: 39
Issue: 3
Pages: 311-7
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Publication
15330337 | J:312751
First Author: Cataldo AM
Year: 2004
Journal: J Neuropathol Exp Neurol
Title: Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.
Volume: 63
Issue: 8
Pages: 821-30
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Publication
23468919 | J:197172
First Author: Wadghiri YZ
Year: 2013
Journal: PLoS One
Title: Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer's disease transgenic mice using magnetic resonance microimaging.
Volume: 8
Issue: 2
Pages: e57097
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Publication
24316473 | J:208026
 
First Author: Marjańska M
Year: 2014
Journal: Neuroscience
Title: Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization.
Volume: 259
Pages: 94-100
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Publication
34659251 | J:312699
 
First Author: Antequera D
Year: 2021
Journal: Front Immunol
Title: Salivary Lactoferrin Expression in a Mouse Model of Alzheimer's Disease.
Volume: 12
Pages: 749468
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Publication
11796757 | J:73607
First Author: Zheng H
Year: 2002
Journal: J Neurochem
Title: Modulation of A(beta) peptides by estrogen in mouse models.
Volume: 80
Issue: 1
Pages: 191-6
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Publication
26315370 | J:232251
First Author: Varnum MM
Year: 2015
Journal: Neurobiol Aging
Title: The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease.
Volume: 36
Issue: 11
Pages: 2995-3007
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Publication
23595759 | J:196964
First Author: Corbett BF
Year: 2013
Journal: J Neurosci
Title: Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.
Volume: 33
Issue: 16
Pages: 7020-6
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Publication
11290552 | J:68670
First Author: Matsuoka Y
Year: 2001
Journal: Am J Pathol
Title: Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.
Volume: 158
Issue: 4
Pages: 1345-54
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Publication
16091461 | J:101060
First Author: Marjanska M
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy.
Volume: 102
Issue: 33
Pages: 11906-10
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Publication
29477640 | J:268459
 
First Author: Zhang L
Year: 2018
Journal: Neurobiol Dis
Title: Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane.
Volume: 114
Pages: 1-16
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Publication
16733088 | J:111313
First Author: Ethell DW
Year: 2006
Journal: Neurobiol Dis
Title: Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice.
Volume: 23
Issue: 2
Pages: 351-61
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Publication
16460878 | J:106997
First Author: Noda-Saita K
Year: 2006
Journal: Neuroscience
Title: Quantitative analysis of amyloid plaques in a mouse model of Alzheimer's disease by phase-contrast X-ray computed tomography.
Volume: 138
Issue: 4
Pages: 1205-13
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Genotype
Genotype
Symbol: Psen1/Psen1
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: C57BL/6 * DBA/2 * SJL * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: C57BL/6 * DBA/2 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PRNP-APPSweInd)8Dwst/? Tg(PSEN1*L286V)1274Citr/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPDutch)#Jckr/? Tg(Thy1-PSEN1*G384A)45Jckr/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPDutch)#Jckr/? Tg(Thy1-PSEN1*G384A)45Jckr/?
Background: involves: C57BL/6 * C57BL/6J * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Hmgcr-PSEN1*M146L)#Lpr/? Tg(Thy1-APPLon)2Vln/?
Background: involves: C57BL/6 * CBA * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: C57BL/6 * DBA/2 * SJL * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/?
Background: involves: C57BL/6 * C57BL/6N * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Tg(PDGFB-PSEN1)1Jhd/?
Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hdac6/Hdac6 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? Trem2/Trem2<+>
Background: involves: C57BL/6J * C57BL/6NTac
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Psen2/Psen2
Background: involves: 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Publication
26566997 | J:340366
 
First Author: Xu G
Year: 2015
Journal: Acta Neuropathol Commun
Title: Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.
Volume: 3
Pages: 72
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Protein Coding Gene
MGI:1913590 | Psenen
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30373880 | J:269026
First Author: Wang ZH
Year: 2018
Journal: J Exp Med
Title: Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
Volume: 215
Issue: 12
Pages: 3038-3056
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Publication
32595447 | J:311244
 
First Author: Loeffler T
Year: 2020
Journal: Front Neurosci
Title: Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value.
Volume: 14
Pages: 579
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Publication
35394029 | J:324255
 
First Author: Koller EJ
Year: 2022
Journal: Dis Model Mech
Title: Temporal and spatially controlled APP transgene expression using Cre-dependent alleles.
Volume: 15
Issue: 5
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Publication
36352225 | J:339995
First Author: Drieu A
Year: 2022
Journal: Nature
Title: Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid.
Volume: 611
Issue: 7936
Pages: 585-593
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Publication
34262178 | J:335093
First Author: McAlpine CS
Year: 2021
Journal: Nature
Title: Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
Volume: 595
Issue: 7869
Pages: 701-706
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Publication
30046111 | J:265289
First Author: Da Mesquita S
Year: 2018
Journal: Nature
Title: Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease.
Volume: 560
Issue: 7717
Pages: 185-191
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Publication
28602351 | J:324482
First Author: Keren-Shaul H
Year: 2017
Journal: Cell
Title: A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Volume: 169
Issue: 7
Pages: 1276-1290.e17
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Publication
37541210 | J:339355
First Author: Yoo Y
Year: 2023
Journal: Cell Stem Cell
Title: A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease.
Volume: 30
Issue: 8
Pages: 1043-1053.e6
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Publication
35573205 | J:328754
First Author: Takahashi F
Year: 2022
Journal: iScience
Title: Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1.
Volume: 25
Issue: 5
Pages: 104278
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Publication
33076948 | J:303244
First Author: Serneels L
Year: 2020
Journal: Mol Neurodegener
Title: Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease.
Volume: 15
Issue: 1
Pages: 60
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Publication
29859094 | J:264653
First Author: Cheng-Hathaway PJ
Year: 2018
Journal: Mol Neurodegener
Title: The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Volume: 13
Issue: 1
Pages: 29
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Publication
30911686 | J:278879
 
First Author: Woo JA
Year: 2019
Journal: Commun Biol
Title: Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics.
Volume: 2
Pages: 112
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Publication
29724785 | J:265685
First Author: Reichenbach N
Year: 2018
Journal: J Exp Med
Title: P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.
Volume: 215
Issue: 6
Pages: 1649-1663
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Strain
MGI:5301810 | FVB.Cg-Abcc1<tm1Bor> Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
16774924 | J:116517
First Author: Culbert AA
Year: 2006
Journal: J Biol Chem
Title: MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.
Volume: 281
Issue: 33
Pages: 23658-67
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Publication
18467698 | J:136190
First Author: Ermini FV
Year: 2008
Journal: Am J Pathol
Title: Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis.
Volume: 172
Issue: 6
Pages: 1520-8
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Publication
14751770 | J:128645
First Author: Boutajangout A
Year: 2004
Journal: Neurobiol Dis
Title: Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.
Volume: 15
Issue: 1
Pages: 47-60
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Publication
15921918 | J:102542
First Author: Köhler C
Year: 2005
Journal: Neurobiol Dis
Title: Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels.
Volume: 20
Issue: 2
Pages: 528-40
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Publication
28637503 | J:312842
First Author: Steffen J
Year: 2017
Journal: Acta Neuropathol Commun
Title: Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.
Volume: 5
Issue: 1
Pages: 49
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Strain
MGI:4452508 | C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:5301852 | FVB.Cg-Abcg2<tm1Ahs> Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Attribute String: congenic, targeted mutation, transgenic
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Publication
31235932 | J:281622
First Author: Leyns CEG
Year: 2019
Journal: Nat Neurosci
Title: TREM2 function impedes tau seeding in neuritic plaques.
Volume: 22
Issue: 8
Pages: 1217-1222
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Publication
23178247 | J:194214
First Author: Vom Berg J
Year: 2012
Journal: Nat Med
Title: Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.
Volume: 18
Issue: 12
Pages: 1812-9
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Publication
23999102 | J:204530
First Author: Heilbronner G
Year: 2013
Journal: EMBO Rep
Title: Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice.
Volume: 14
Issue: 11
Pages: 1017-22
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Publication
23100432 | J:192173
First Author: Cameron B
Year: 2012
Journal: J Neurosci
Title: Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease.
Volume: 32
Issue: 43
Pages: 15112-23
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Publication
19213921 | J:144934
First Author: Thathiah A
Year: 2009
Journal: Science
Title: The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.
Volume: 323
Issue: 5916
Pages: 946-51
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Publication
24893973 | J:241976
 
First Author: Ulrich JD
Year: 2014
Journal: Mol Neurodegener
Title: Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.
Volume: 9
Pages: 20
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Publication
26458768 | J:229027
First Author: Prokop S
Year: 2015
Journal: J Exp Med
Title: Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice.
Volume: 212
Issue: 11
Pages: 1811-8
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Publication
28701326 | J:249736
First Author: Ye L
Year: 2017
Journal: EMBO Rep
Title: Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis.
Volume: 18
Issue: 9
Pages: 1536-1544
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Publication
18077058 | J:152963
First Author: Priller C
Year: 2009
Journal: Neurobiol Aging
Title: Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice.
Volume: 30
Issue: 8
Pages: 1227-37
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Publication
36443293 | J:331959
First Author: Rother C
Year: 2022
Journal: Nat Commun
Title: Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae.
Volume: 13
Issue: 1
Pages: 7333
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Publication
25911278 | J:224496
First Author: Mahler J
Year: 2015
Journal: Neurobiol Aging
Title: Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.
Volume: 36
Issue: 7
Pages: 2241-2247
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Publication
29472246 | J:262255
 
First Author: Steeland S
Year: 2018
Journal: EMBO Mol Med
Title: Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease.
Volume: 10
Issue: 4
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Publication
30667373 | J:270447
First Author: Beckelman BC
Year: 2019
Journal: J Clin Invest
Title: Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.
Volume: 129
Issue: 2
Pages: 820-833
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Publication
28768717 | J:248773
First Author: Agís-Balboa RC
Year: 2017
Journal: EMBO J
Title: Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.
Volume: 36
Issue: 19
Pages: 2815-2828
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Publication
36611872 | J:332599
 
First Author: Rudan Njavro J
Year: 2022
Journal: Cells
Title: Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.
Volume: 12
Issue: 1
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Publication
26663083 | J:259402
First Author: Schnöder L
Year: 2016
Journal: J Biol Chem
Title: Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.
Volume: 291
Issue: 5
Pages: 2067-79
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Publication
25675483 | J:220176
First Author: Han BH
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice.
Volume: 112
Issue: 8
Pages: E881-90
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Publication
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