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Search results 701 to 800 out of 899 for Crh

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Hits by Pathway

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Type Details Score
Allele
Irs4<tm1.1(cre)Dolsn> | MGI:6720261
Name: insulin receptor substrate 4; targeted mutation 1.1, David P Olson
Allele Type: Targeted
Attribute String: Recombinase
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Strain
MGI:4457103 | B6;FVB-Tg(Crh-cre)1Kres/J
Attribute String: mutant stock, transgenic
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Strain
MGI:5003752 | STOCK Tg(Crh-EGFP)HS57Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Strain
MGI:6116860 | B6.Cg-Crh<tm1.1(flpo)Bsab>/J
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Crh<tm1.1(cre)Dolsn> | MGI:5559540
Name: corticotropin releasing hormone; targeted mutation 1.1, David P Olson
Allele Type: Targeted
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Crh/Crh<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Crh-cre)1Kres/?
Background: involves: C57BL/6 * FVB
Zygosity: ot
Has Mutant Allele: true
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Publication
26061727 | J:226947
First Author: Nahar J
Year: 2015
Journal: Endocrinology
Title: Rapid Nongenomic Glucocorticoid Actions in Male Mouse Hypothalamic Neuroendocrine Cells Are Dependent on the Nuclear Glucocorticoid Receptor.
Volume: 156
Issue: 8
Pages: 2831-42
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Publication
19455148 | J:225039
First Author: Kimura M
Year: 2010
Journal: Mol Psychiatry
Title: Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep.
Volume: 15
Issue: 2
Pages: 154-65
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Publication
22113086 | J:225019
First Author: Molander A
Year: 2012
Journal: Neuropsychopharmacology
Title: Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking.
Volume: 37
Issue: 4
Pages: 1047-56
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Transgene
MGI:3055441 | Tg(Crh)227.1Pbl
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(Crh)227.1Pbl/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:5562356 | B6;129P2-Crhr1<tm1Wrst>/Ieg
Attribute String: targeted mutation, mutant stock
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Publication
15496472 | J:93458
First Author: Chen Y
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus.
Volume: 101
Issue: 44
Pages: 15782-7
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Publication
17316992 | J:141737
First Author: Schierloh A
Year: 2007
Journal: Neurosci Lett
Title: Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity.
Volume: 416
Issue: 1
Pages: 82-6
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Publication
11988580 | J:76358
First Author: Sillaber I
Year: 2002
Journal: Science
Title: Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.
Volume: 296
Issue: 5569
Pages: 931-3
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Publication
19020499 | J:224810
First Author: Risbrough VB
Year: 2009
Journal: Neuropsychopharmacology
Title: CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues.
Volume: 34
Issue: 6
Pages: 1494-503
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Allele
Hprt1<tm353(Ple274-icre/ERT2)Ems> | MGI:5568222
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 353, Elizabeth M Simpson
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Crhr1/Crhr1<+>
Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crhr1/Crhr1
Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Camk2a-cre/ERT2)2Gsc/?
Background: involves: 129S2/SvPas * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crhr1/Crhr1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Publication
18475271 | J:149207
First Author: Lu A
Year: 2008
Journal: Mol Psychiatry
Title: Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior.
Volume: 13
Issue: 11
Pages: 1028-42
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Publication
19077175 | J:151140
First Author: Kamprath K
Year: 2009
Journal: Genes Brain Behav
Title: Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling.
Volume: 8
Issue: 2
Pages: 203-11
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Publication
8600981 | J:32964
First Author: Slominski A
Year: 1996
Journal: Biochim Biophys Acta
Title: The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin.
Volume: 1289
Issue: 2
Pages: 247-51
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Protein
Q60571
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
Q3UY07
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
A0A217FL62
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Publication
22405007 | -
First Author: Carpenter B
Year: 2012
Journal: Structure
Title: Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.
Volume: 20
Issue: 3
Pages: 487-97
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Publication
28270795 | -
 
First Author: Wauman J
Year: 2017
Journal: Front Endocrinol (Lausanne)
Title: The Leptin Receptor Complex: Heavier Than Expected?
Volume: 8
Pages: 30
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Protein Domain
IPR041182 | LEP-R_IGD
Type: Domain
Description: This is the immunoglobulin-like domain (IGD) found in leptin receptors (LEP-R), also known as obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity [, ].
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Allele
Star<tm1Klp> | MGI:2388706
Name: steroidogenic acute regulatory protein; targeted mutation 1, Keith L Parker
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
8872315 | J:34915
First Author: Giardino L
Year: 1996
Journal: Brain Res Mol Brain Res
Title: CRH-R1 mRNA expression in two strains of inbred mice and its regulation after repeated restraint stress.
Volume: 40
Issue: 2
Pages: 310-4
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HT Experiment
E-GEOD-33457 | Amygdalar gene expression from Mecp2-null and MECP2-transgenic mice
Series Id: GSE33457
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
22992651 | J:190101
First Author: Gafford GM
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Cell-type specific deletion of GABA(A)α1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction.
Volume: 109
Issue: 40
Pages: 16330-5
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Strain
MGI:5568554 | B6.Cg-Hprt1<tm353(Ple274-icre/ERT2)Ems>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5568358 | B6.Cg-Hprt1<tm353(Ple274-icre/ERT2)Ems>/Mmjax
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Hprt1/?
Background: B6.Cg-Hprt1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Irs4/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ot
Has Mutant Allele: true
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Publication
15465594 | J:132461
First Author: Murray SE
Year: 2004
Journal: J Neuroimmunol
Title: Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks.
Volume: 156
Issue: 1-2
Pages: 31-41
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Publication
19379774 | J:149839
First Author: Fenzl T
Year: 2009
Journal: Behav Brain Res
Title: Circadian rhythms of basal orexin levels in the hypothalamus are not influenced by an impaired corticotropin-releasing hormone receptor type 1 system.
Volume: 203
Issue: 1
Pages: 143-5
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Publication
- | J:13615
 
First Author: Mann SJ
Year: 1972
Journal: Mouse News Lett
Title: crh.
Volume: 47
Pages: 64
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Publication
16081071 | J:100335
First Author: Ware CB
Year: 2005
Journal: FEBS Lett
Title: Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis.
Volume: 579
Issue: 20
Pages: 4465-9
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Protein Coding Gene
MGI:102760 | Star
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Star/Star
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Publication
21940453 | J:177121
First Author: Wang XD
Year: 2011
Journal: J Neurosci
Title: Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits.
Volume: 31
Issue: 38
Pages: 13625-34
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Publication
18591672 | J:143954
First Author: Pastor R
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism.
Volume: 105
Issue: 26
Pages: 9070-5
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Publication
26257395 | J:235994
First Author: Hurt RC
Year: 2015
Journal: Genes Brain Behav
Title: Angiotensin type 1a receptors on corticotropin-releasing factor neurons contribute to the expression of conditioned fear.
Volume: 14
Issue: 7
Pages: 526-33
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Nes-cre)1Kln/?
Background: involves: 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh<+> Mc4r/Mc4r
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Crh-cre)1Kres/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Crh-cre)1Kres/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-Bgeo/GFP)21Lbe/? Tg(Crh-cre)1Kres/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Publication
7853396 | -
First Author: van Nuland NA
Year: 1995
Journal: J Mol Biol
Title: High-resolution structure of the phosphorylated form of the histidine-containing phosphocarrier protein HPr from Escherichia coli determined by restrained molecular dynamics from NMR-NOE data.
Volume: 246
Issue: 1
Pages: 180-93
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Publication
1549615 | -
First Author: Herzberg O
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Structure of the histidine-containing phosphocarrier protein HPr from Bacillus subtilis at 2.0-A resolution.
Volume: 89
Issue: 6
Pages: 2499-503
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Publication
7704530 | -
First Author: Liao DI
Year: 1994
Journal: Structure
Title: Refined structures of the active Ser83-->Cys and impaired Ser46-->Asp histidine-containing phosphocarrier proteins.
Volume: 2
Issue: 12
Pages: 1203-16
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Publication
11054290 | -
First Author: Audette GF
Year: 2000
Journal: J Mol Biol
Title: The 1.9 A resolution structure of phospho-serine 46 HPr from Enterococcus faecalis.
Volume: 303
Issue: 4
Pages: 545-53
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Publication
15713472 | -
First Author: Sridharan S
Year: 2005
Journal: J Mol Biol
Title: The HPr proteins from the thermophile Bacillus stearothermophilus can form domain-swapped dimers.
Volume: 346
Issue: 3
Pages: 919-31
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Publication
16316990 | -
First Author: Schumacher MA
Year: 2006
Journal: J Biol Chem
Title: Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation.
Volume: 281
Issue: 10
Pages: 6793-800
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Publication
7556876 | J:27447
First Author: Cortright DN
Year: 1995
Journal: Mol Cell Endocrinol
Title: Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein.
Volume: 111
Issue: 2
Pages: 147-57
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Publication
9703949 | J:49069
First Author: Zídek V
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Quantitative trait loci for compensatory renal hypertrophy in the mouse.
Volume: 248
Issue: 3
Pages: 473-5
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Publication
26135556 | J:248600
First Author: Hooper A
Year: 2016
Journal: Hippocampus
Title: Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone.
Volume: 26
Issue: 1
Pages: 41-53
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Publication
12973355 | J:85745
First Author: Müller MB
Year: 2003
Journal: Nat Neurosci
Title: Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.
Volume: 6
Issue: 10
Pages: 1100-7
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Publication
10500222 | J:57963
First Author: Karolyi IJ
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice.
Volume: 96
Issue: 20
Pages: 11595-600
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Publication
17904108 | J:127335
First Author: Bjursell M
Year: 2007
Journal: Biochem Biophys Res Commun
Title: GPR10 deficiency in mice results in altered energy expenditure and obesity.
Volume: 363
Issue: 3
Pages: 633-8
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Publication
11329063 | J:114061
First Author: Hsu SY
Year: 2001
Journal: Nat Med
Title: Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.
Volume: 7
Issue: 5
Pages: 605-11
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Publication
7956345 | J:22103
First Author: Broad TE
Year: 1995
Journal: Cytogenet Cell Genet
Title: Assignment of five loci from human chromosome 8q onto sheep chromosome 9.
Volume: 68
Issue: 1-2
Pages: 102-6
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Publication
12960076 | J:85769
First Author: Araki O
Year: 2003
Journal: Endocrinology
Title: Expression of type 2 iodothyronine deiodinase in corticotropin-secreting mouse pituitary tumor cells is stimulated by glucocorticoid and corticotropin-releasing hormone.
Volume: 144
Issue: 10
Pages: 4459-65
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Publication
15923664 | J:99194
First Author: Iserentant H
Year: 2005
Journal: J Cell Sci
Title: Mapping of the interface between leptin and the leptin receptor CRH2 domain.
Volume: 118
Issue: Pt 11
Pages: 2519-27
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Publication
25430741 | J:218182
First Author: Romanov RA
Year: 2015
Journal: EMBO J
Title: A secretagogin locus of the mammalian hypothalamus controls stress hormone release.
Volume: 34
Issue: 1
Pages: 36-54
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Publication
30535142 | J:269093
First Author: Kameda H
Year: 2019
Journal: Endocrinology
Title: Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice.
Volume: 160
Issue: 2
Pages: 276-291
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Protein Domain
IPR000032 | HPr-like
Type: Domain
Description: This entry represents a structural domain found in both the histidine-containing phosphocarrier protein HPr, as well as its structural homologues, which includes the catabolite repression protein Crh found in Bacillus subtilis [, ]. This domain has a alpha+beta structure found in two layers with an overall architecture of an open faced β-sandwich in which a β-sheet is packed against three α-helices. The histidine-containing phosphocarrier protein (HPr) is a central component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which transfers metabolic carbohydrates across the cell membrane in many bacterial species [, ]. PTS catalyses the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The general mechanism of the PTS is as follows: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred to Enzyme I (EI) of the PTS, which in turn transfers it to the phosphoryl carrier protein (HPr) [, ]. Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease complex (enzymes EII/EIII). HPr [, ]is a small cytoplasmic protein of 70 to 90 amino acid residues. In some bacteria, HPr is a domain in a larger protein that includes a EIII(Fru) (IIA) domain and in some cases also the EI domain. A conserved histidine in the N-terminal section of HPr serves as an acceptor for the phosphoryl group of EI. In the central part of HPr, there is a conserved serine which (in Gram-positive bacteria only) is phosphorylated by an ATP-dependent protein kinase; a process which probably play a regulatory role in sugar transport. Regulatory phosphorylation at the conserved Ser residue does not appear to induce large structural changes to the HPr domain, in particular in the region of the active site [, ].
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Protein Domain
IPR035895 | HPr-like_sf
Type: Homologous_superfamily
Description: This entry represents a structural domain found in both the histidine-containing phosphocarrier protein HPr, as well as its structural homologues, which includes the catabolite repression protein Crh found in Bacillus subtilis [, ]. This domain has a alpha+beta structure found in two layers with an overall architecture of an open faced β-sandwich in which a β-sheet is packed against three α-helices. The histidine-containing phosphocarrier protein (HPr) is a central component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which transfers metabolic carbohydrates across the cell membrane in many bacterial species [, ]. PTS catalyses the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The general mechanism of the PTS is as follows: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred to Enzyme I (EI) of the PTS, which in turn transfers it to the phosphoryl carrier protein (HPr) [, ]. Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease complex (enzymes EII/EIII). HPr [, ]is a small cytoplasmic protein of 70 to 90 amino acid residues. In some bacteria, HPr is a domain in a larger protein that includes a EIII(Fru) (IIA) domain and in some cases also the EI domain. A conserved histidine in the N-terminal section of HPr serves as an acceptor for the phosphoryl group of EI. In the central part of HPr, there is a conserved serine which (in Gram-positive bacteria only) is phosphorylated by an ATP-dependent protein kinase; a process which probably play a regulatory role in sugar transport. Regulatory phosphorylation at the conserved Ser residue does not appear to induce large structural changes to the HPr domain, in particular in the region of the active site [, ].
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Publication
27240530 | J:339554
First Author: Hartmann J
Year: 2017
Journal: Mol Psychiatry
Title: Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor.
Volume: 22
Issue: 3
Pages: 466-475
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Publication
22030710 | J:225021
First Author: Thoeringer CK
Year: 2012
Journal: Neuropsychopharmacology
Title: Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus.
Volume: 37
Issue: 3
Pages: 787-96
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Publication
29593501 | J:276737
 
First Author: Gong Q
Year: 2018
Journal: Front Cell Neurosci
Title: Chronic Stress Reduces Nectin-1 mRNA Levels and Disrupts Dendritic Spine Plasticity in the Adult Mouse Perirhinal Cortex.
Volume: 12
Pages: 67
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Genotype
Genotype
Symbol: Crh/Crh<+> Mc4r/Mc4r Oxt/Oxt<+>
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129 * C57BL/6J * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Publication
17596444 | J:122977
First Author: Heisler LK
Year: 2007
Journal: J Neurosci
Title: Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.
Volume: 27
Issue: 26
Pages: 6956-64
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