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Search results 201 to 300 out of 302 for Ros1

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Hits by Strain

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2840725
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8C
Note: Expression is at the terminal endings of the ureteric tubules.
Specimen Label: 8C
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2840725
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8E
Note: Expression is at the terminal endings of the ureteric tubules.
Specimen Label: 8E
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6506833
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672820
Stage: TS20
Assay Id: MGI:6506834
Age: embryonic day 12.5
Specimen Label: 6 - Category C - E12.5
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3809680
Age: postnatal adult
Image: 7A,B
Specimen Label: 7A,B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8A
Specimen Label: 8A
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8B
Specimen Label: 8B
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6144286
Assay Type: RNA in situ
Annotation Date: 2018-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6144287
Age: embryonic day 12.5
Specimen Label: not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6144286
Assay Type: RNA in situ
Annotation Date: 2018-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6144287
Age: embryonic day 12.5
Note: Same as in the control.
Specimen Label: not shown
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6144286
Assay Type: RNA in situ
Annotation Date: 2018-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6144287
Age: embryonic day 14.5
Note: Same as in the control.
Specimen Label: not shown
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6506833
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:6506834
Age: embryonic day 15.5
Note: There is a broad domain of tip expression.
Specimen Label: 3 - Class II
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6506833
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6506834
Age: embryonic day 12.5
Specimen Label: 5 - E12.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6506833
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6506834
Age: embryonic day 15.5
Specimen Label: 5 - E15.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2823925
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8D
Specimen Label: 8D
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2823925
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8E
Specimen Label: 8E
Detected: false
Specimen Num: 6
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•
GXD Expression
GXD Expression
 
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8G
Specimen Label: 8G
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8H
Specimen Label: 8H
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3809680
Age: embryonic day 17.5
Image: 8J
Specimen Label: 8J
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:16449
Assay Type: RNA in situ
Annotation Date: 2008-10-06
Strength: Present
Sex: Male
Emaps: EMAPS:3148828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3809680
Age: postnatal adult
Image: 7A,B
Specimen Label: 7A,B
Detected: true
Specimen Num: 1
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Publication
25401476 | J:219378
First Author: Ali ZA
Year: 2014
Journal: J Clin Invest
Title: Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1.
Volume: 124
Issue: 12
Pages: 5159-74
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Publication
37531264 | J:343008
     
First Author: Kiyozumi D
Year: 2023
Journal: Biol Reprod
Title: ADGRG2 is dispensable for lumicrine signalling regulating epididymal initial segment differentiation and gene expression†.
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Publication
32499443 | J:290452
First Author: Kiyozumi D
Year: 2020
Journal: Science
Title: NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility.
Volume: 368
Issue: 6495
Pages: 1132-1135
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Publication
37095084 | J:335479
First Author: Kiyozumi D
Year: 2023
Journal: Nat Commun
Title: A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility.
Volume: 14
Issue: 1
Pages: 2354
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Publication
12890734 | J:86162
First Author: Cooper TG
Year: 2003
Journal: Biol Reprod
Title: Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice.
Volume: 69
Issue: 5
Pages: 1750-62
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Publication
11266449 | J:67582
First Author: Keilhack H
Year: 2001
Journal: J Cell Biol
Title: Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Volume: 152
Issue: 2
Pages: 325-34
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Publication
9021139 | J:38058
First Author: Bryda EC
Year: 1997
Journal: Mamm Genome
Title: A high-resolution genetic map around waltzer on mouse chromosome 10 and identification of a new allele of waltzer.
Volume: 8
Issue: 1
Pages: 1-4
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Publication
10051318 | J:53815
First Author: Vacher J
Year: 1999
Journal: Mamm Genome
Title: Genetic localization and transmission of the mouse osteopetrotic grey-lethal mutation.
Volume: 10
Issue: 3
Pages: 239-43
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Publication
7854358 | J:21389
First Author: Chen F
Year: 1994
Journal: Mol Endocrinol
Title: Cloning of a novel orphan receptor (GCNF) expressed during germ cell development.
Volume: 8
Issue: 10
Pages: 1434-44
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Publication
7705639 | J:22501
First Author: Lee GH
Year: 1995
Journal: Genetics
Title: Identification of hepatocarcinogen-resistance genes in DBA/2 mice.
Volume: 139
Issue: 1
Pages: 387-95
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Publication
7990960 | J:21884
First Author: Stark K
Year: 1994
Journal: Nature
Title: Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.
Volume: 372
Issue: 6507
Pages: 679-83
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Publication
33246328 | J:301719
First Author: Su J
Year: 2021
Journal: Biol Reprod
Title: ZC3H4-a novel Cys-Cys-Cys-His-type zinc finger protein-is essential for early embryogenesis in mice†.
Volume: 104
Issue: 2
Pages: 325-335
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Publication
8812055 | J:31897
First Author: Fan CM
Year: 1996
Journal: Mol Cell Neurosci
Title: Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.
Volume: 7
Issue: 1
Pages: 1-16
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Publication
10575223 | J:58636
First Author: Karayianni E
Year: 1999
Journal: Cytogenet Cell Genet
Title: Transcriptional map of chromosome region 6q16-->q21.
Volume: 86
Issue: 3-4
Pages: 263-6
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Publication
9151674 | J:40187
First Author: Miner JH
Year: 1997
Journal: J Cell Biol
Title: The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.
Volume: 137
Issue: 3
Pages: 685-701
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Publication
1975791 | J:10716
First Author: Justice MJ
Year: 1990
Journal: Genetics
Title: A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.
Volume: 125
Issue: 4
Pages: 855-66
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Publication
1370487 | J:2596
First Author: Haefliger JA
Year: 1992
Journal: J Biol Chem
Title: Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.
Volume: 267
Issue: 3
Pages: 2057-64
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Publication
1673105 | J:11120
First Author: Siracusa LD
Year: 1991
Journal: Genetics
Title: Identification and applications of repetitive probes for gene mapping in the mouse.
Volume: 127
Issue: 1
Pages: 169-79
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Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
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Publication
28705898 | J:243411
First Author: Rutledge EA
Year: 2017
Journal: Development
Title: Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Volume: 144
Issue: 17
Pages: 3177-3188
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
26372962 | J:226993
First Author: Davare MA
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.
Volume: 112
Issue: 39
Pages: E5381-90
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Publication
28717217 | J:258365
First Author: Ogura H
Year: 2017
Journal: Sci Rep
Title: TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
Volume: 7
Issue: 1
Pages: 5519
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Allele
Ros1<+> | MGI:2431962
   
Name: Ros1 proto-oncogene; wild type
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Allele
Ros1<tm1Char> | MGI:5500168
 
Name: Ros1 proto-oncogene; targeted mutation 1, Alain Charest
Allele Type: Targeted
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Allele
Ros1<tm1.1Char> | MGI:5500177
Name: Ros1 proto-oncogene; targeted mutation 1.1, Alain Charest
Allele Type: Targeted
Attribute String: Hypomorph
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Allele
Ros1<tm1Cbm> | MGI:2450566
Name: Ros1 proto-oncogene; targeted mutation 1, Carmen Birchmeier
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ros1<tm2Cbm> | MGI:2450662
Name: Ros1 proto-oncogene; targeted mutation 2, Carmen Birchmeier
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
24155752 | -
 
First Author: Qüesta JI
Year: 2013
Journal: Front Plant Sci
Title: DDM1 and ROS1 have a role in UV-B induced- and oxidative DNA damage in A. thaliana.
Volume: 4
Pages: 420
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Publication
25240767 | -
First Author: Hong S
Year: 2014
Journal: J Mol Biol
Title: The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activity.
Volume: 426
Issue: 22
Pages: 3703-3712
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Publication
33470193 | -
   
First Author: Halter T
Year: 2021
Journal: Elife
Title: The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions.
Volume: 10
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Allele
Ros1<tm1e(KOMP)Wtsi> | MGI:4457516
Name: Ros1 proto-oncogene; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ros1<tm1a(KOMP)Wtsi> | MGI:4456658
Name: Ros1 proto-oncogene; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Ros1<tm1c(KOMP)Wtsi> | MGI:7444939
Name: Ros1 proto-oncogene; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Ros1/Ros1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ros1/Ros1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ros1/Ros1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ros1/Ros1
Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL
Zygosity: hm
Has Mutant Allele: true
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Allele
Ros1<em1Osb> | MGI:6460274
Name: Ros1 proto-oncogene; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6344876 | C57BL/6N-A<tm1Brd> Ros1<tm1a(KOMP)Wtsi>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6460275 | B6;D2-Ros1<em1Osb>/Osb
Attribute String: endonuclease-mediated mutation, mutant stock
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Genotype
Genotype
Symbol: Ros1/Ros1
Background: involves: C57BL/6NJcl * DBA/2NJcl
Zygosity: hm
Has Mutant Allele: true
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Allele
Tg(SFTPC-CD74/ROS1)125Tno | MGI:5806502
Name: transgene insertion 125, Tetsuo Noda
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Protein Domain
IPR028924 | Perm-CXXC
Type: Domain
Description: This is a permuted version of a single unit of the zf-CXXC domain that is detected in the Demeter-like proteins and ROS1 (REPRESSOR OF SILENCING 1) from plants []. Demeter and ROS1 proteins catalyse the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism []. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases []. The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides.
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Strain
MGI:5806504 | C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno
Attribute String: transgenic, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Tg(SFTPC-CD74/ROS1)125Tno/?
Background: C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno
Zygosity: ot
Has Mutant Allele: true
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Publication
16624880 | -
First Author: Morales-Ruiz T
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases.
Volume: 103
Issue: 18
Pages: 6853-8
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Publication
25228464 | -
First Author: Lee J
Year: 2014
Journal: Nucleic Acids Res
Title: AP endonucleases process 5-methylcytosine excision intermediates during active DNA demethylation in Arabidopsis.
Volume: 42
Issue: 18
Pages: 11408-18
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Publication
30275307 | -
First Author: Liu J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Mutations in the DNA demethylase OsROS1 result in a thickened aleurone and improved nutritional value in rice grains.
Volume: 115
Issue: 44
Pages: 11327-11332
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Publication
32528522 | -
 
First Author: Kong W
Year: 2020
Journal: Front Genet
Title: Impact of DNA Demethylases on the DNA Methylation and Transcription of Arabidopsis NLR Genes.
Volume: 11
Pages: 460
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Publication
29784956 | -
First Author: Zhang H
Year: 2018
Journal: Nat Rev Mol Cell Biol
Title: Dynamics and function of DNA methylation in plants.
Volume: 19
Issue: 8
Pages: 489-506
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Publication
12526807 | -
First Author: Gong Z
Year: 2002
Journal: Cell
Title: ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase.
Volume: 111
Issue: 6
Pages: 803-14
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Protein Domain
IPR044811 | DME/ROS1
Type: Family
Description: DNA glycosylases are required to regulate the DNA methylation pathway at discrete regions across the plant genome, and probably protect the genome from excess methylation []. Arabidopsis encodes four active demethylases with 5-methylcytosine DNA glycosylase/lyase activities, namely DEMETER (DME), DME-Like 1 (DML1)/ROS1 (Repressor of Silencing 1), DML2 and DML3 [, , , ]. Both ROS1 and DME actively remove DNA methylation in all methylated cytosine contexts through a base excision repair (BER) mechanism [, ]. DML2/3 and ROS1 play important roles in the regulation of nucleotide-binding leucine-rich repeat (NLR) genes, a class of important plant disease resistance genes [].DEMETER functions mainly in the central cells of female gametophytes involved in gene imprinting, which allows the expression of the maternal copy of the imprinted MEA gene before fertilization, possibly by antagonizing or suppressing DNA methylation on target promoter []and acts in a sequence nonspecific manner. The other three demethylases, ROS1, DML2, and DML3, were shown to be largely active in somatic cells []. ROS1 is constitutively expressed and regulates gene expression by preventing the spread of DNA methylation and transcriptional silencing from transposons and is involved in UV-B induced- and oxidative DNA damage repair []. It also regulates defence genes by demethylation of RMG1 (disease resistance gene) and RLP43 (an orphan immune receptor gene) promoters [].
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Publication
26964870 | J:231770
First Author: Inoue M
Year: 2016
Journal: Carcinogenesis
Title: Mouse models for ROS1-fusion-positive lung cancers and their application to the analysis of multikinase inhibitor efficiency.
Volume: 37
Issue: 5
Pages: 452-60
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Publication
24132104 | J:205211
First Author: Shaw AT
Year: 2013
Journal: Nat Rev Cancer
Title: Tyrosine kinase gene rearrangements in epithelial malignancies.
Volume: 13
Issue: 11
Pages: 772-87
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Publication
24154728 | J:202905
First Author: Saborowski A
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target.
Volume: 110
Issue: 48
Pages: 19513-8
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Publication
37244438 | J:336409
 
First Author: Giaccone G
Year: 2023
Journal: Semin Cancer Biol
Title: Current knowledge of small cell lung cancer transformation from non-small cell lung cancer.
Volume: 94
Pages: 1-10
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Publication
21507349 | -
 
First Author: Iyer LM
Year: 2011
Journal: Prog Mol Biol Transl Sci
Title: Natural history of eukaryotic DNA methylation systems.
Volume: 101
Pages: 25-104
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Publication
23418494 | J:199415
First Author: Arai Y
Year: 2013
Journal: PLoS One
Title: Mouse model for ROS1-rearranged lung cancer.
Volume: 8
Issue: 2
Pages: e56010
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