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Search results 301 to 388 out of 388 for Izumo1

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0.03s
Type Details Score
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264201
Specimen Label: RBRC_264201
Specimen Num: 140
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264065
Specimen Label: RBRC_264065
Specimen Num: 117
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264237
Specimen Label: RBRC_264237
Specimen Num: 158
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_263973
Specimen Label: RBRC_263973
Specimen Num: 26
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_263975
Specimen Label: RBRC_263975
Specimen Num: 27
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_263977
Specimen Label: RBRC_263977
Specimen Num: 28
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264131
Specimen Label: RBRC_264131
Specimen Num: 70
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264133
Specimen Label: RBRC_264133
Specimen Num: 71
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264135
Specimen Label: RBRC_264135
Specimen Num: 72
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264039
Specimen Label: RBRC_264039
Specimen Num: 104
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264041
Specimen Label: RBRC_264041
Specimen Num: 105
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264043
Specimen Label: RBRC_264043
Specimen Num: 106
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264213
Specimen Label: RBRC_264213
Specimen Num: 146
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264215
Specimen Label: RBRC_264215
Specimen Num: 147
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264217
Specimen Label: RBRC_264217
Specimen Num: 148
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_263941
Specimen Label: RBRC_263941
Specimen Num: 10
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Female
Emaps: EMAPS:1915328
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264083
Specimen Label: RBRC_264083
Detected: false
Specimen Num: 46
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264013
Specimen Label: RBRC_264013
Specimen Num: 91
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264173
Specimen Label: RBRC_264173
Specimen Num: 126
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264005
Specimen Label: RBRC_264005
Specimen Num: 42
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264007
Specimen Label: RBRC_264007
Specimen Num: 43
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264167
Specimen Label: RBRC_264167
Specimen Num: 88
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_263999
Specimen Label: RBRC_263999
Detected: true
Specimen Num: 39
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264001
Specimen Label: RBRC_264001
Detected: true
Specimen Num: 40
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264157
Specimen Label: RBRC_264157
Detected: true
Specimen Num: 83
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264159
Specimen Label: RBRC_264159
Detected: true
Specimen Num: 84
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264161
Specimen Label: RBRC_264161
Detected: true
Specimen Num: 85
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264163
Specimen Label: RBRC_264163
Detected: true
Specimen Num: 86
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Female
Emaps: EMAPS:1881228
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_263943
Specimen Label: RBRC_263943
Detected: false
Specimen Num: 11
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Female
Emaps: EMAPS:1881228
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264085
Specimen Label: RBRC_264085
Detected: false
Specimen Num: 47
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264015
Specimen Label: RBRC_264015
Specimen Num: 92
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692255
Age: postnatal adult
Image: RBRC_264175
Specimen Label: RBRC_264175
Specimen Num: 127
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: mutant strain, targeted mutation, congenic
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: coisogenic, targeted mutation
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Strain
Attribute String: endonuclease-mediated mutation, mutant stock
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Allele
Name: IZUMO1 receptor, JUNO; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Strain
Attribute String: coisogenic, targeted mutation
Genotype
Symbol: Izumo1r/Izumo1r
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Izumo1r/Izumo1r
Background: B6.129P2(Cg)-Izumo1r
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Izumo1r/Izumo1r
Background: involves: C57BL/6N * C57BL/6NTac
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Izumo1r/Izumo1r
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Izumo1r/Izumo1r
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Izumo1r/Izumo1r
Background: C57BL/6N-Izumo1r/Rbrc
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Izumo1r/Izumo1r
Background: C57BL/6N-Izumo1r/Wtsi
Zygosity: hm
Has Mutant Allele: true
Allele
Name: transgene insertion 1, Research Institute for Microbial Diseases, Osaka University
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
Publication
First Author: Nishimura K
Year: 2016
Journal: Curr Biol
Title: The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins.
Volume: 26
Issue: 14
Pages: R661-2
Protein
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
Strain
Attribute String: mutant strain, targeted mutation
Strain
Attribute String: endonuclease-mediated mutation, mutant stock
Strain
Attribute String: mutant strain, endonuclease-mediated mutation
Genotype
Symbol: Izumo1r/Izumo1r<+>
Background: C57BL/6N-Izumo1r/Rbrc
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Spiegelstein O
Year: 2000
Journal: Gene
Title: Identification of two putative novel folate receptor genes in humans and mouse.
Volume: 258
Issue: 1-2
Pages: 117-25
Publication
First Author: Chalbi M
Year: 2014
Journal: Development
Title: Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization.
Volume: 141
Issue: 19
Pages: 3732-9
Allele
Name: transgene insertion 1, Naokazu Inoue
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
Strain
Attribute String: mutant strain, transgenic
Publication
First Author: Cherukad J
Year: 2012
Journal: Placenta
Title: Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development.
Volume: 33
Issue: 5
Pages: 440-8
Protein Domain
Type: Domain
Description: This is the immunoglobulin domain on Izumo proteins from higher eukaryotes. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif - glycosylation site. The full-length human IZUMO1 protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilisation []. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204) []. There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific [, ].
Strain
Attribute String: transgenic, mutant stock, targeted mutation
Publication    
First Author: Lamas-Toranzo I
Year: 2020
Journal: Elife
Title: TMEM95 is a sperm membrane protein essential for mammalian fertilization.
Volume: 9
Publication
First Author: Barbaux S
Year: 2020
Journal: Sci Rep
Title: Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion.
Volume: 10
Issue: 1
Pages: 5335
Publication
First Author: Rival CM
Year: 2019
Journal: Nat Commun
Title: Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization.
Volume: 10
Issue: 1
Pages: 4456
Publication
First Author: Ohnami N
Year: 2012
Journal: Biol Open
Title: CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte.
Volume: 1
Issue: 7
Pages: 640-7
Publication
First Author: Noda T
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice.
Volume: 117
Issue: 21
Pages: 11493-11502
Publication
First Author: Fujihara Y
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice.
Volume: 117
Issue: 17
Pages: 9393-9400
Publication
First Author: Lorenzetti D
Year: 2014
Journal: Mamm Genome
Title: A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion.
Volume: 25
Issue: 3-4
Pages: 141-8
Publication
First Author: Marcello MR
Year: 2011
Journal: J Biol Chem
Title: Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.
Volume: 286
Issue: 15
Pages: 13060-70
Publication
First Author: Ito C
Year: 2018
Journal: Reproduction
Title: Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion.
Volume: 156
Issue: 6
Pages: 579-590
Publication
First Author: Hao H
Year: 2022
Journal: Mol Biomed
Title: The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding.
Volume: 3
Issue: 1
Pages: 27
Publication
First Author: Rubinstein E
Year: 2006
Journal: Semin Cell Dev Biol
Title: The molecular players of sperm-egg fusion in mammals.
Volume: 17
Issue: 2
Pages: 254-63
Publication      
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load