Dact (dapper) proteins were identified through binding to dishevelled, a cytoplasmic protein central to Wnt signaling. The different dact proteins seem to have distinct signaling and developmental roles. In Zebrafish, dact1 but not dact2 is required to enhance Wnt/beta-catenin activity, while functional interaction with Wnt/Ca2+-PCP signaling has been described for dact2, but not dact1 []. Data from other vertebrates seems to be consistent with a distinct signaling and developmental role for dact1, dact2 and dact3 [].Dact3 (dapper homologue 3) belongs to the dapper family and it is known to be expressed in brain and uterus [].
Dact (dapper) proteins were identified through binding to dishevelled, a cytoplasmic protein central to Wnt signaling. The different dact proteins seem to have distinct signaling and developmental roles. In Zebrafish, dact1 but not dact2 is required to enhance Wnt/beta-catenin activity, while functional interaction with Wnt/Ca2+-PCP signaling has been described for dact2, but not dact1 []. Data from other vertebrates seems to be consistent with a distinct signaling and developmental role for dact1, dact2 and dact3 [].This entry represents dact2.
Dact (dapper) proteins were identified through binding to dishevelled, a cytoplasmic protein central to Wnt signaling. The different dact proteins seem to have distinct signaling and developmental roles. In Zebrafish, dact1 but not dact2 is required to enhance Wnt/beta-catenin activity, while functional interaction with Wnt/Ca2+-PCP signaling has been described for dact2, but not dact1 []. Data from other vertebrates seems to be consistent with a distinct signaling and developmental role for dact1, dact2 and dact3 [].
Dact (dapper) proteins were identified through binding to dishevelled, a cytoplasmic protein central to Wnt signaling. The different dact proteins seem to have distinct signaling and developmental roles. In Zebrafish, dact1 but not dact2 is required to enhance Wnt/beta-catenin activity, while functional interaction with Wnt/Ca2+-PCP signaling has been described for dact2, but not dact1 []. Data from other vertebrates seems to be consistent with a distinct signaling and developmental role for dact1, dact2 and dact3 [].This entry represents dact1. Dact1 is the orthologue of a protein known in Xenopus as dapper or frodo [].
