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Search results 101 to 190 out of 190 for Bag3

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Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691516
Age: postnatal adult
Image: MRC Harwell_901075
Specimen Label: MRC Harwell_901075
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691516
Age: postnatal adult
Image: MRC Harwell_901099
Specimen Label: MRC Harwell_901099
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691516
Age: postnatal adult
Image: MRC Harwell_901093
Specimen Label: MRC Harwell_901093
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691516
Age: postnatal adult
Image: MRC Harwell_901099
Specimen Label: MRC Harwell_901099
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691516
Age: postnatal adult
Image: MRC Harwell_901095
Specimen Label: MRC Harwell_901095
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691516
Age: postnatal adult
Image: MRC Harwell_901083
Specimen Label: MRC Harwell_901083
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691516
Age: postnatal adult
Image: MRC Harwell_901085
Specimen Label: MRC Harwell_901085
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691516
Age: postnatal adult
Image: MRC Harwell_901095
Specimen Label: MRC Harwell_901095
Detected: true
Specimen Num: 13
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Publication
33572816 | J:305951
 
First Author: Yun HH
Year: 2021
Journal: Int J Mol Sci
Title: An Adult Mouse Model of Dilated Cardiomyopathy Caused by Inducible Cardiac-Specific Bis Deletion.
Volume: 22
Issue: 3
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Publication
10597216 | J:58551
First Author: Lee JH
Year: 1999
Journal: Oncogene
Title: Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Volume: 18
Issue: 46
Pages: 6183-90
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Publication
36948186 | J:334906
First Author: Chua BA
Year: 2023
Journal: Cell Stem Cell
Title: Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis.
Volume: 30
Issue: 4
Pages: 460-472.e6
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Publication
17942418 | J:172174
First Author: Wood AJ
Year: 2007
Journal: Nucleic Acids Res
Title: Allele-specific demethylation at an imprinted mammalian promoter.
Volume: 35
Issue: 20
Pages: 7031-9
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Publication
20060297 | J:156684
First Author: Arndt V
Year: 2010
Journal: Curr Biol
Title: Chaperone-assisted selective autophagy is essential for muscle maintenance.
Volume: 20
Issue: 2
Pages: 143-8
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Publication
11527400 | J:94503
First Author: Antoku K
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein.
Volume: 286
Issue: 5
Pages: 1003-10
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Publication
33742095 | J:305082
First Author: Pathak P
Year: 2021
Journal: Commun Biol
Title: Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation.
Volume: 4
Issue: 1
Pages: 355
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Publication
27171814 | J:243708
First Author: Bang ML
Year: 2017
Journal: J Cell Physiol
Title: Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.
Volume: 232
Issue: 1
Pages: 38-52
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Publication
36109497 | J:328990
First Author: Patel T
Year: 2022
Journal: Nat Commun
Title: Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.
Volume: 13
Issue: 1
Pages: 5427
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Publication
30104731 | J:267025
First Author: Jung H
Year: 2018
Journal: Nat Neurosci
Title: Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice.
Volume: 21
Issue: 9
Pages: 1218-1228
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Publication
11591653 | J:103507
First Author: Suzuki H
Year: 2001
Journal: Genome Res
Title: Protein-protein interaction panel using mouse full-length cDNAs.
Volume: 11
Issue: 10
Pages: 1758-65
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Tg(Myh6*/tetO-BAG3)69Atsa | MGI:6294697
Name: transgene insertion 69, Atsushi Sanbe
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Allele
Bag3<tm2.1Chen> | MGI:6369096
Name: BCL2-associated athanogene 3; targeted mutation 2.1, Ju Chen
Allele Type: Targeted
Attribute String: No functional change
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Allele
Tg(Myh6-BAG3*P209L)#Mswi | MGI:6324028
Name: transgene insertion, Monte S Willis
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
26541455 | J:233197
First Author: Liu J
Year: 2015
Journal: Biochem Biophys Res Commun
Title: MiR-143 enhances the antitumor activity of shikonin by targeting BAG3 expression in human glioblastoma stem cells.
Volume: 468
Issue: 1-2
Pages: 105-12
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Publication
35857625 | J:330799
First Author: Yang J
Year: 2022
Journal: Sci Transl Med
Title: Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy.
Volume: 14
Issue: 652
Pages: eabl5654
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Genotype
Genotype
Symbol: Tg(Myh6-BAG3*P209L)#Mswi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Allele
Bag3<tm1c(EUCOMM)Hmgu> | MGI:5760384
Name: BCL2-associated athanogene 3; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready
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Interaction Experiment
Hishiya A (2010)
Description: BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress.
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Publication
26159920 | -
First Author: Jin YH
Year: 2015
Journal: Biochem Biophys Res Commun
Title: BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress.
Volume: 464
Issue: 2
Pages: 561-7
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Transgene
MGI:6324027 | Tg(Myh6-BAG3*P209L)#Mswi
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Bag3/Bag3 Tg(Myhca-cre)1Abel/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bag3/Bag3 Tg(Myhca-cre)1Abel/?
Background: involves: C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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DO Term
DOID:0110448 | dilated cardiomyopathy 1HH
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DO Term
DOID:0080097 | myofibrillar myopathy 6
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Allele
Bag3<em1Smoc> | MGI:7288428
Name: BCL2-associated athanogene 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Bag3<tm1Chen> | MGI:6107851
Name: BCL2-associated athanogene 3; targeted mutation 1, Ju Chen
Allele Type: Targeted
Attribute String: Humanized sequence
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Publication
17304582 | -
First Author: Hu Z
Year: 2007
Journal: J Neurosci Res
Title: Structure, function, property, and role in neurologic diseases and other diseases of the sHsp22.
Volume: 85
Issue: 10
Pages: 2071-9
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Publication
18006506 | -
First Author: Carra S
Year: 2008
Journal: J Biol Chem
Title: HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.
Volume: 283
Issue: 3
Pages: 1437-44
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Publication
18094623 | -
First Author: Carra S
Year: 2008
Journal: Autophagy
Title: HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy.
Volume: 4
Issue: 2
Pages: 237-9
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Publication
18832141 | -
First Author: Houlden H
Year: 2008
Journal: Neurology
Title: Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2.
Volume: 71
Issue: 21
Pages: 1660-8
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Publication
23796487 | -
First Author: Nakhro K
Year: 2013
Journal: Neuromuscul Disord
Title: A novel Lys141Thr mutation in small heat shock protein 22 (HSPB8) gene in Charcot-Marie-Tooth disease type 2L.
Volume: 23
Issue: 8
Pages: 656-63
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Publication
17718384 | -
First Author: Laskowska E
Year: 2007
Journal: Postepy Biochem
Title: [Small heat shock proteins--role in apoptosis, cancerogenesis and diseases associated with protein aggregation].
Volume: 53
Issue: 1
Pages: 19-26
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Publication
22521623 | -
First Author: Acunzo J
Year: 2012
Journal: Int J Biochem Cell Biol
Title: Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death.
Volume: 44
Issue: 10
Pages: 1622-31
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Protein Domain
IPR042790 | HspB8_ACD
Type: Domain
Description: This entry represents the alpha-crystallin domain (ACD) found in mammalian 21.6 kDa small heat shock protein (sHsp) HspB8, also known as Hsp22 in humans []. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits []. A chaperone complex formed of HspB8 and Bag3 stimulates degradation of protein complexes by macroautophagy [, ]. HspB8 also forms complexes with Hsp27 (HspB1), MKBP (HspB2), HspB3, alphaB-crystallin (HspB5), Hsp20 (HspB6), and cvHsp (HspB7). These latter interactions may depend on phosphorylation of the respective partner sHsp. HspB8 may participate in the regulation of cell proliferation, cardiac hypertrophy, apoptosis, and carcinogenesis [, ].Point mutations in HspB8 have been correlated with the development of several congenital neurological diseases, including Charcot Marie tooth disease and distal motor neuropathy type II [, ].
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Publication
30559469 | J:271313
First Author: Fu H
Year: 2019
Journal: Nat Neurosci
Title: A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.
Volume: 22
Issue: 1
Pages: 47-56
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Publication
14594798 | -
First Author: Sun X
Year: 2004
Journal: J Biol Chem
Title: Interaction of human HSP22 (HSPB8) with other small heat shock proteins.
Volume: 279
Issue: 4
Pages: 2394-402
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Publication
24180415 | J:308149
First Author: Banerjee Mustafi S
Year: 2014
Journal: Antioxid Redox Signal
Title: Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system.
Volume: 20
Issue: 18
Pages: 2891-906
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Publication
24130164 | J:316053
First Author: Chuma M
Year: 2014
Journal: Carcinogenesis
Title: Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor-κB/mitogen-activated protein kinase.
Volume: 35
Issue: 2
Pages: 272-81
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Publication
26490709 | J:254480
 
First Author: Rusmini P
Year: 2015
Journal: Sci Rep
Title: Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy.
Volume: 5
Pages: 15174
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Publication
24324403 | J:313658
 
First Author: Crippa V
Year: 2013
Journal: Front Cell Neurosci
Title: Differential autophagy power in the spinal cord and muscle of transgenic ALS mice.
Volume: 7
Pages: 234
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Publication
29311767 | J:256069
 
First Author: Sebastiani A
Year: 2017
Journal: Front Neurosci
Title: Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice.
Volume: 11
Pages: 678
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Publication
27169926 | J:251175
First Author: Diaz-Hidalgo L
Year: 2016
Journal: Biochim Biophys Acta
Title: Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions.
Volume: 1863
Issue: 8
Pages: 2084-92
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Protein
Q9JK92
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: false
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