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Search results 1 to 100 out of 171 for Scap

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0.037s

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Type Details Score
Gene
22937 | SCAP
Type: gene
Organism: human
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Gene
460334 | SCAP
Type: gene
Organism: chimpanzee
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Gene
507878 | SCAP
Type: gene
Organism: cattle
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Gene
420380 | SCAP
Type: gene
Organism: chicken
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Gene
558292 | scap
Type: gene
Organism: zebrafish
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Gene
711528 | SCAP
Type: gene
Organism: macaque, rhesus
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Gene
100145201 | scap
Type: gene
Organism: frog, western clawed
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Gene
301024 | Scap
Type: gene
Organism: rat
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Gene
484782 | SCAP
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:2135958 | Scap
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR030225 | SCAP
Type: Family
Description: Sterol regulatory element-binding protein cleavage-activating protein (SCAP) is a escort protein required for cholesterol and lipid homeostasis []. It is an endoplasmic reticulum protein with eight transmembrane helices that serves as a cholesterol sensor []. In cholesterol-depleted cells, SCAP transports sterol regulatory element-binding proteins (SREBPs) to the Golgi, where the active fragment of SREBP is liberated by proteases so that it can activate genes for cholesterol synthesis [].A homologue of SCAP exists in Schizosaccharomyces pombe, named Scp1, which together with Sre1 (homologue to SREBP), may mediate a hypoxic response by monitoring oxygen-dependent sterol synthesis []..
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Publication
11358865 | J:69592
First Author: Matsuda M
Year: 2001
Journal: Genes Dev
Title: SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.
Volume: 15
Issue: 10
Pages: 1206-16
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Protein
Q6GQT6
Organism: Mus musculus/domesticus
Length: 1276  
Fragment?: false
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Publication
21454655 | -
First Author: Motamed M
Year: 2011
Journal: J Biol Chem
Title: Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis.
Volume: 286
Issue: 20
Pages: 18002-12
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Publication
19948958 | J:155526
First Author: Verheijen MH
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: SCAP is required for timely and proper myelin membrane synthesis.
Volume: 106
Issue: 50
Pages: 21383-8
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Publication
25896350 | J:225543
First Author: McFarlane MR
Year: 2015
Journal: J Lipid Res
Title: Scap is required for sterol synthesis and crypt growth in intestinal mucosa.
Volume: 56
Issue: 8
Pages: 1560-71
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Publication
16054043 | J:129815
First Author: Kuriyama H
Year: 2005
Journal: Cell Metab
Title: Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.
Volume: 1
Issue: 1
Pages: 41-51
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Publication
26900919 | J:247225
First Author: Chen W
Year: 2016
Journal: PLoS Pathog
Title: ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs.
Volume: 12
Issue: 2
Pages: e1005462
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Publication
33227706 | J:308923
 
First Author: Li Z
Year: 2021
Journal: Biomed Pharmacother
Title: SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth.
Volume: 133
Pages: 111011
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Publication
37024487 | J:334528
First Author: Zheng G
Year: 2023
Journal: Cell Death Dis
Title: SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
Volume: 14
Issue: 4
Pages: 249
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Publication
19074148 | J:147592
First Author: Besnard V
Year: 2009
Journal: J Biol Chem
Title: Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.
Volume: 284
Issue: 6
Pages: 4018-30
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Publication
23585733 | J:197684
First Author: Suzuki R
Year: 2013
Journal: PLoS Biol
Title: Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
Volume: 11
Issue: 4
Pages: e1001532
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Publication
30462530 | J:288003
First Author: Li D
Year: 2019
Journal: FASEB J
Title: SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE-/- mice.
Volume: 33
Issue: 3
Pages: 3437-3450
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Publication
29899135 | J:264124
 
First Author: Tsushima H
Year: 2018
Journal: Development
Title: Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.
Volume: 145
Issue: 13
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Publication
12242332 | J:79403
First Author: Yabe D
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Volume: 99
Issue: 20
Pages: 12753-8
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Protein
A0A0G2JFZ9
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: true
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Protein
A0A0G2JEV4
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Publication
17428920 | -
First Author: Radhakrishnan A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.
Volume: 104
Issue: 16
Pages: 6511-8
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Publication
15797383 | -
First Author: Hughes AL
Year: 2005
Journal: Cell
Title: SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.
Volume: 120
Issue: 6
Pages: 831-42
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Protein
E9PY17
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
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Publication
22751013 | J:211761
First Author: Camargo N
Year: 2012
Journal: FASEB J
Title: High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism.
Volume: 26
Issue: 10
Pages: 4302-15
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Publication
35380992 | J:325010
 
First Author: Kawamura S
Year: 2022
Journal: J Clin Invest
Title: Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.
Volume: 132
Issue: 11
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Publication
29068315 | J:249975
   
First Author: Zhang L
Year: 2017
Journal: Elife
Title: Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.
Volume: 6
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Publication
22326225 | J:182284
First Author: Moon YA
Year: 2012
Journal: Cell Metab
Title: The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.
Volume: 15
Issue: 2
Pages: 240-6
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Publication
27866836 | J:251961
First Author: Papazyan R
Year: 2016
Journal: Cell Metab
Title: Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.
Volume: 24
Issue: 6
Pages: 863-874
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Publication
37267109 | J:341034
First Author: Fei X
Year: 2023
Journal: Cell Rep
Title: The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB.
Volume: 42
Issue: 6
Pages: 112586
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Publication
27601673 | J:238350
First Author: Shimizu-Albergine M
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.
Volume: 113
Issue: 38
Pages: E5685-93
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Publication
24806461 | J:216084
First Author: Bridges JP
Year: 2014
Journal: PLoS One
Title: Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation.
Volume: 9
Issue: 5
Pages: e91376
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Publication
20739508 | J:170224
First Author: Rudolph MC
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium.
Volume: 299
Issue: 6
Pages: E918-27
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Publication
27137100 | J:344770
 
First Author: Hashimoto M
Year: 2016
Journal: J Steroid Biochem Mol Biol
Title: Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.
Volume: 163
Pages: 121-8
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Protein Coding Gene
MGP_CAROLIEiJ_G0032729 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035345 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035257 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035321 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035029 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2135958 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035843 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034335 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034996 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035155 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035102 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035234 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035142 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034042 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034456 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015596 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033877 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
28920951 | J:305308
First Author: Assmann N
Year: 2017
Journal: Nat Immunol
Title: Srebp-controlled glucose metabolism is essential for NK cell functional responses.
Volume: 18
Issue: 11
Pages: 1197-1206
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GXD Expression
GXD Expression
   
Probe: MGI:6111794
Assay Type: RT-PCR
Annotation Date: 2018-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6111878
Age: postnatal
Image: 5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6111794
Assay Type: RT-PCR
Annotation Date: 2018-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6111878
Age: postnatal
Image: 5
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1653615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7464095
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7464101
Age: embryonic day 14.5
Image: 1C lung SCAP+/+
Specimen Label: 1C lung SCAP+/+
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:7464095
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7464101
Age: embryonic day 14.5
Image: 1C lung SCAPfl/fl
Specimen Label: 1C lung SCAPfl/fl
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610515
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7464095
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7464101
Age: embryonic day 14.5
Image: 1C liver SCAP+/+
Specimen Label: 1C liver SCAP+/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7464095
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7464101
Age: embryonic day 14.5
Image: 1C liver SCAPfll/fl
Specimen Label: 1C liver SCAPfll/fl
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7464095
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7464101
Age: embryonic day 14.5
Image: 1C aorta SCAP+/+
Specimen Label: 1C aorta SCAP+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7464095
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-18
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:1620422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7464101
Age: embryonic day 14.5
Image: 1C aorta SCAPfl/fl
Note: Expression levels significantly lower than in +/+ mice.
Specimen Label: 1C aorta SCAPfl/fl
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3609776
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3610156
Age: embryonic day 14.5
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3609776
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3610156
Age: embryonic day 16.5
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1654315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1638815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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Publication
37244259 | J:337727
First Author: Yan C
Year: 2023
Journal: Cancer Cell
Title: Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.
Volume: 41
Issue: 7
Pages: 1276-1293.e11
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Publication
21195348 | J:169478
First Author: Tang JJ
Year: 2011
Journal: Cell Metab
Title: Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques.
Volume: 13
Issue: 1
Pages: 44-56
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Publication
26686653 | J:227982
First Author: York AG
Year: 2015
Journal: Cell
Title: Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.
Volume: 163
Issue: 7
Pages: 1716-29
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Publication
31303399 | J:282652
First Author: Kusnadi A
Year: 2019
Journal: Immunity
Title: The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.
Volume: 51
Issue: 2
Pages: 241-257.e9
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Publication
31270208 | J:281312
First Author: Xiaoli AM
Year: 2019
Journal: J Biol Chem
Title: Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms.
Volume: 294
Issue: 34
Pages: 12743-12753
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Publication
17666524 | J:128622
First Author: Li J
Year: 2007
Journal: Physiol Genomics
Title: Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia.
Volume: 31
Issue: 2
Pages: 273-80
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Publication
28846071 | J:252691
First Author: Rong X
Year: 2017
Journal: J Clin Invest
Title: ER phospholipid composition modulates lipogenesis during feeding and in obesity.
Volume: 127
Issue: 10
Pages: 3640-3651
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Publication
22337502 | J:181551
First Author: Verdier V
Year: 2012
Journal: Glia
Title: Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways.
Volume: 60
Issue: 5
Pages: 751-60
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Publication
23563690 | J:196681
First Author: Kidani Y
Year: 2013
Journal: Nat Immunol
Title: Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Volume: 14
Issue: 5
Pages: 489-99
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Publication
28747429 | J:244377
     
First Author: Zhang Y
Year: 2017
Journal: Genes Dev
Title: The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ.
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Publication
14512514 | J:86192
First Author: Horton JD
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.
Volume: 100
Issue: 21
Pages: 12027-32
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Publication
37066875 | J:335125
 
First Author: Guan D
Year: 2023
Journal: J Clin Invest
Title: Hepatocyte SREBP signaling mediates clock communication within the liver.
Volume: 133
Issue: 8
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Publication
32694855 | J:321860
First Author: Gong XM
Year: 2019
Journal: Nat Metab
Title: Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.
Volume: 1
Issue: 5
Pages: 570-583
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Publication
25593129 | J:241200
First Author: Tarling EJ
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2.
Volume: 35
Issue: 4
Pages: 787-95
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Publication
27251289 | J:233670
First Author: Sallam T
Year: 2016
Journal: Nature
Title: Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.
Volume: 534
Issue: 7605
Pages: 124-8
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Publication
28244871 | J:241873
   
First Author: Rong S
Year: 2017
Journal: Elife
Title: Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.
Volume: 6
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Publication
30057115 | J:272719
First Author: Guan D
Year: 2018
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