|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 363 out of 363 for Tnfrsf21

<< First    < Previous  |  Next >    Last >>
0.022s

Categories

Hits by Strain

Hits by Category

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4416751
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828846
Age: embryonic day 14.5
Image: euxassay_012361_19
Specimen Label: euxassay_012361_19
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4416751
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828846
Age: embryonic day 14.5
Image: euxassay_012361_20
Specimen Label: euxassay_012361_20
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4416751
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828846
Age: embryonic day 14.5
Image: euxassay_012361_21
Specimen Label: euxassay_012361_21
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4416751
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828846
Age: embryonic day 14.5
Image: euxassay_012361_22
Specimen Label: euxassay_012361_22
Detected: true
Specimen Num: 22
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002286
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5542840
Age: embryonic day 15.5
Image: GUDMAP:8451
Specimen Label: GUDMAP:8451
Detected: false
Specimen Num: 1
•
•
•
•
•
Publication
- | J:71002
   
First Author: Isogai D
Year: 2000
Journal: GenBank Submission
Title: Mus musculus DR6 mRNA, complete cds
Pages: AF322069
•
•
•
•
•
Publication
- | J:72473
   
First Author: Kim V
Year: 2001
Journal: GenBank Submission
Title: Mus musculus death receptor 6 mRNA, complete cds
Pages: AY043489
•
•
•
•
•
Publication
29526794 | J:280442
 
First Author: Fernandes KA
Year: 2018
Journal: Exp Eye Res
Title: Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.
Volume: 171
Pages: 54-61
•
•
•
•
•
Publication
24806669 | J:211050
First Author: Kallop DY
Year: 2014
Journal: J Neurosci
Title: A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.
Volume: 34
Issue: 19
Pages: 6425-37
•
•
•
•
•
Publication
32963272 | J:296186
First Author: Yong Y
Year: 2020
Journal: Sci Rep
Title: Regulation of degenerative spheroids after injury.
Volume: 10
Issue: 1
Pages: 15472
•
•
•
•
•
Publication
23559013 | J:205745
 
First Author: Hu Y
Year: 2013
Journal: Cell Death Dis
Title: A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death.
Volume: 4
Pages: e579
•
•
•
•
•
Publication
27354516 | J:234406
First Author: Marik SA
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Physiological role for amyloid precursor protein in adult experience-dependent plasticity.
Volume: 113
Issue: 28
Pages: 7912-7
•
•
•
•
•
Publication
22427645 | J:184057
First Author: Boivin GA
Year: 2012
Journal: J Immunol
Title: Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68.
Volume: 188
Issue: 8
Pages: 3949-60
•
•
•
•
•
Publication
31628183 | J:282344
First Author: Yong Y
Year: 2019
Journal: J Neurosci
Title: p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture.
Volume: 39
Issue: 48
Pages: 9503-9520
•
•
•
•
•
Publication
24806670 | J:211049
First Author: Olsen O
Year: 2014
Journal: J Neurosci
Title: Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.
Volume: 34
Issue: 19
Pages: 6438-47
•
•
•
•
•
Publication
27487218 | J:296726
First Author: Strilic B
Year: 2016
Journal: Nature
Title: Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.
Volume: 536
Issue: 7615
Pages: 215-8
•
•
•
•
•
Publication
27622990 | J:345276
First Author: Hao J
Year: 2017
Journal: Kidney Int
Title: Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6.
Volume: 91
Issue: 1
Pages: 106-118
•
•
•
•
•
Publication
11239407 | J:74923
First Author: Locksley RM
Year: 2001
Journal: Cell
Title: The TNF and TNF receptor superfamilies: integrating mammalian biology.
Volume: 104
Issue: 4
Pages: 487-501
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
•
•
•
•
•
Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
•
•
•
•
•
Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
•
•
•
•
•
Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Allele
Tnfrsf21<em1Smoc> | MGI:7292887
Name: tumor necrosis factor receptor superfamily, member 21; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Publication
22567163 | -
First Author: Yang K
Year: 2012
Journal: PLoS One
Title: DR6 as a diagnostic and predictive biomarker in adult sarcoma.
Volume: 7
Issue: 5
Pages: e36525
•
•
•
•
•
Publication
9714541 | -
First Author: Pan G
Year: 1998
Journal: FEBS Lett
Title: Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.
Volume: 431
Issue: 3
Pages: 351-6
•
•
•
•
•
Publication
23084432 | -
First Author: Qiu CW
Year: 2012
Journal: Med Hypotheses
Title: A new therapy for the reduction of axon and neuron loss and promotion of axon and oligodendrocyte regeneration through inhibition of death receptor 6 pathway after ischemic cerebral stroke.
Volume: 79
Issue: 6
Pages: 853-5
•
•
•
•
•
Protein Domain
IPR034034 | TNFRSF21_N
Type: Domain
Description: Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also known as death receptor 6 (DR6), CD358, or BM-018, is highly expressed in differentiating neurons as well as in the adult brain, and is upregulated in injured neurons []. DR6 negatively regulates neuron, axon, and oligodendrocyte survival, hinders axondendrocyte and oligodendrocyte regeneration and its inhibition has a neuro-protective effect in nerve injury []. It activates nuclear factor kappa-B (NFkB) and mitogen-activated protein kinase 8 (MAPK8, also called c-Jun N-terminal kinase 1), and induces cell apoptosis by associating with TNFRSF1A-associated via death domain (TRADD), which is known to mediate signal transduction of tumor necrosis factor receptors []. TNFRSF21 plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation []. It binds alpha-amyloid precursor protein (APP); when released, APP binds in an autocrine/paracrine manner to activate a caspase-dependent self-destruction program that removes unnecessary or connectionless axons []. Increasing beta-catenin levels in brain endothelium upregulates TNFRSF21 and TNFRSF19, indicating that these death receptors are downstream target genes of Wnt/beta-catenin signaling, which has been shown to be required for blood-brain barrier development []. DR6 is up-regulated in numerous solid tumors as well as in tumor vascular cells, including ovarian cancer and may be a clinically useful diagnostic and predictive serum biomarker for some adult sarcoma subtypes [].This entry represents the N-terminal domain of TNFRSF21. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].
•
•
•
•
•
Publication
18353537 | J:136076
First Author: Courter LA
Year: 2008
Journal: Cancer Lett
Title: The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Volume: 265
Issue: 1
Pages: 135-47
•
•
•
•
•
Protein
Q3UPV2
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
•
•
•
•
•
Protein
Q9EPU5
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
•
•
•
•
•
Publication
9538693 | -
First Author: Naismith JH
Year: 1998
Journal: Trends Biochem Sci
Title: Modularity in the TNF-receptor family.
Volume: 23
Issue: 2
Pages: 74-9
•
•
•
•
•
Publication
11796220 | -
First Author: Bodmer JL
Year: 2002
Journal: Trends Biochem Sci
Title: The molecular architecture of the TNF superfamily.
Volume: 27
Issue: 1
Pages: 19-26
•
•
•
•
•
Publication
8387891 | -
First Author: Banner DW
Year: 1993
Journal: Cell
Title: Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Volume: 73
Issue: 3
Pages: 431-45
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom