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Search results 201 to 253 out of 253 for Hus1

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0.059s

Type

Details

Score

Protein Coding Gene

MGP_PWKPhJ_G0019443 | -

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGP_WSBEiJ_G0019750 | -

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGP_PahariEiJ_G0019460 | -

Type:	protein_coding_gene
Organism:	Mus pahari

•

Protein Coding Gene

MGP_SPRETEiJ_G0019264 | -

Type:	protein_coding_gene
Organism:	Mus spretus

•

Publication

21659603 | -

First Author:	Cotta-Ramusino C
Year:	2011
Journal:	Science
Title:	A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Volume:	332
Issue:	6035
Pages:	1313-7

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Interaction Experiment

Lim PX (2015)

Description:

Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions.

•

Allele

Hus1<tm1e(EUCOMM)Hmgu> | MGI:5497044

Name:	HUS1 checkpoint clamp component; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type:	Targeted
Attribute String:	Null/knockout, Reporter

•

Allele

Hus1<Gt(XS0122)Wtsi> | MGI:4344911

Name:	HUS1 checkpoint clamp component; gene trap XS0122, Wellcome Trust Sanger Institute
Allele Type:	Gene trapped

•

Allele

Hus1<tm1a(EUCOMM)Hmgu> | MGI:5497101

Name:	HUS1 checkpoint clamp component; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type:	Targeted
Attribute String:	Conditional ready, Null/knockout, Reporter

•

Allele

Hus1<tm1(KOMP)Mbp> | MGI:5014521

Name:	HUS1 checkpoint clamp component; targeted mutation 1, Mouse Biology Program, UC Davis
Allele Type:	Targeted
Attribute String:	Null/knockout, Reporter

•

Strain

MGI:7577048 | C57BL/6JGpt-Hus1<em1Gpt>/Gpt

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

Genotype

Symbol:	Hus1/Hus1
Background:	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hus1/Hus1
Background:	involves: 129S4/SvJaeSor * 129S6/SvEvTac
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hus1/Hus1
Background:	involves: 129S6/SvEvTac
Zygosity:	hm
Has Mutant Allele:	true

•

Publication

25911100 | -

First Author:	Lim PX
Year:	2015
Journal:	J Biol Chem
Title:	Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions.
Volume:	290
Issue:	24
Pages:	14826-40

•

Genotype

Symbol:	Hus1/Hus1<+>
Background:	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Cdkn1a/Cdkn1a Hus1/Hus1
Background:	involves: 129S6/SvEvTac
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Hus1/Hus1
Background:	involves: 129S6/SvEvTac * C57BL/6
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Hus1/Hus1 Tg(Hsp70-1-cre)1Arge/?
Background:	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Hus1/Hus1 Trp53/Trp53<+>
Background:	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

14611806 | J:100287

First Author:	Dufault VM
Year:	2003
Journal:	Genomics
Title:	Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene.
Volume:	82
Issue:	6
Pages:	644-51

•

Publication

17145874 | J:116214

First Author:	Ishii H
Year:	2006
Journal:	Cancer Res
Title:	Fhit modulates the DNA damage checkpoint response.
Volume:	66
Issue:	23
Pages:	11287-92

•

Publication

35133274 | J:326477

First Author:	Pereira C
Year:	2022
Journal:	Elife
Title:	Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.
Volume:	11

•

Publication

9180692 | -

First Author:	Kostrub CF
Year:	1997
Journal:	Mol Gen Genet
Title:	Molecular analysis of hus1+, a fission yeast gene required for S-M and DNA damage checkpoints.
Volume:	254
Issue:	4
Pages:	389-99

•

Protein Domain

IPR007150 | Hus1/Mec3

Type:

Family

Description:

This entry consists of the human Hus1 protein and budding yeast Mec3. They are components of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes [, ]. Hus1, Rad1, and Rad9 (which share homology with Mec1, Rad17, Ddc1 in budding yeast) are three evolutionarily conserved proteins required for checkpoint control. These proteins are known to form a stable complex. Structurally, the Ddc1-Mec3-Rad17 complex is similar to the PCNA complex, which forms trimeric ring-shaped clamps. Ddc1-Mec3-Rad17 plays a role in checkpoint activation that permits DNA-repair pathways to prevent cell cycle progression in response to DNA damage and replication stress [, ].

•

Protein Domain

IPR026584 | Rad9

Type:

Family

Description:

This entry includes DNA damage checkpoint proteins Rad9. Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage []. It is worth noting that this entry including the mamalian Rad9, which is homologous to the fission yeast Rad9 and the budding yeast Ddc1. Members of this family do not share the sequence homology with the budding yeast Rad9.Rad9 forms a complex with Hus1 and Rad1, called 9-1-1 complex. In human, 9-1-1 binds to TopBP1 and activates the ATR-Chk1 checkpoint pathway []. Rad9 also shows 3'-5' exonuclease activity []. Besides its function in the 9-1-1 complex, Rad9 can act as a transcriptional factor, participate in immunoglobulin classswitch recombination []. Aberrant Rad9 expression has been associated with prostate, breast, lung, skin, thyroid, and gastric cancers [].

•

Protein

Q9Z0F6

Organism:	Mus musculus/domesticus
Length:	389
Fragment?:	false

•

Protein

Q6WBX7

Organism:	Mus musculus/domesticus
Length:	403
Fragment?:	false

•

Protein

Q8VC54

Organism:	Mus musculus/domesticus
Length:	403
Fragment?:	false

•

Protein

D3Z3W7

Organism:	Mus musculus/domesticus
Length:	366
Fragment?:	false

•

Publication

22034047 | -

First Author:	Broustas CG
Year:	2012
Journal:	J Cell Biochem
Title:	Contributions of Rad9 to tumorigenesis.
Volume:	113
Issue:	3
Pages:	742-51

•

Publication

22925454 | -

First Author:	Ueda S
Year:	2012
Journal:	Genes Cells
Title:	Two serine phosphorylation sites in the C-terminus of Rad9 are critical for 9-1-1 binding to TopBP1 and activation of the DNA damage checkpoint response in HeLa cells.
Volume:	17
Issue:	10
Pages:	807-16

•

Publication

10713044 | -

First Author:	Bessho T
Year:	2000
Journal:	J Biol Chem
Title:	Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease.
Volume:	275
Issue:	11
Pages:	7451-4

•

Publication

20729201 | J:166880

First Author:	An L
Year:	2010
Journal:	J Biol Chem
Title:	Rad9 is required for B cell proliferation and immunoglobulin class switch recombination.
Volume:	285
Issue:	46
Pages:	35267-73

•

Publication

21304913 | J:169551

First Author:	Wit N
Year:	2011
Journal:	PLoS One
Title:	Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.
Volume:	6
Issue:	1
Pages:	e16669

•

Protein

F6VRS2

Organism:	Mus musculus/domesticus
Length:	92
Fragment?:	true

•

Protein

A0A494BAY5

Organism:	Mus musculus/domesticus
Length:	144
Fragment?:	true

•

Protein

A0A494BAL0

Organism:	Mus musculus/domesticus
Length:	73
Fragment?:	false

•

Protein

D3Z515

Organism:	Mus musculus/domesticus
Length:	64
Fragment?:	true

•

Protein

A0A494B9R8

Organism:	Mus musculus/domesticus
Length:	80
Fragment?:	true

•

Protein

Q8QZZ4

Organism:	Mus musculus/domesticus
Length:	122
Fragment?:	true

•

Publication

9755168 | -

First Author:	Vialard JE
Year:	1998
Journal:	EMBO J
Title:	The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.
Volume:	17
Issue:	19
Pages:	5679-88

•

Protein Domain

IPR007268 | Rad9/Ddc1

Type:

Family

Description:

This entry represents the DNA damage checkpoint protein Rad9 and its homologue in budding yeast, Ddc1. Rad9 forms a complex with Hus1 and Rad1 (called 9-1-1 complex). Ddc1 forms a similar complex with Mec1 and Rad17. Structurally, the 9-1-1 / Ddc1-Mec3-Rad17 complex is similar to the PCNA complex, which forms trimeric ring-shaped clamps. The 9-1-1 / Ddc1-Mec3-Rad17 complex plays a role in checkpoint activation that permits DNA-repair pathways to prevent cell cycle progression in response to DNA damage and replication stress [, ].In humans, 9-1-1 binds to TopBP1 and activates the ATR-Chk1 checkpoint pathway []. Besides its function in the 9-1-1 complex, Rad9 can also act as a transcriptional factor and participate in immunoglobulin class switch recombination []. It also shows 3'-5' exonuclease activity []. Aberrant Rad9 expression has been associated with prostate, breast, lung, skin, thyroid, and gastric cancers [].In budding yeast, Ddc1 can activate Mec1 (the principal checkpoint protein kinase, human ATR homologue) in G1 phase. In G2 phase, Ddc1 can either activate Mec1 directly or recruit Dpb11 (the orthologue of human TopBP1) and subsequently activate Mec1 []. Ddc1 does not have DNA exonuclease function [].It is worth noting that the Rad9 proteins referred to in this entry are the mammalian and fission yeast homologues of budding yeast Ddc1. Members of this family do not share the sequence homology another DNA damage-dependent checkpoint protein from budding yeast, confusingly also called Rad9.

•

Publication

9311982 | -

First Author:	Longhese MP
Year:	1997
Journal:	EMBO J
Title:	The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.
Volume:	16
Issue:	17
Pages:	5216-26

•

Publication

21978893 | -

First Author:	Eichinger CS
Year:	2011
Journal:	Trends Biochem Sci
Title:	9-1-1: PCNA's specialized cousin.
Volume:	36
Issue:	11
Pages:	563-8

•

Publication

9891048 | -

First Author:	Kondo T
Year:	1999
Journal:	Mol Cell Biol
Title:	Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway.
Volume:	19
Issue:	2
Pages:	1136-43

•

Publication

20005839 | -

First Author:	Navadgi-Patil VM
Year:	2009
Journal:	Mol Cell
Title:	The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.
Volume:	36
Issue:	5
Pages:	743-53

•

Publication

12604797 | -

First Author:	Majka J
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.
Volume:	100
Issue:	5
Pages:	2249-54

•

Publication

- | J:136110

First Author:	Velocigene
Year:	2008
Journal:	MGI Direct Data Submission
Title:	Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)

•

Publication

- | J:81858

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2003

Title:	Data Curation Using Mouse Genome Assembly

•

Publication

- | J:73796

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Function or Process or Component Unknown following Literature Review

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

•

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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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