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Search results 101 to 200 out of 322 for Scn1a

0.053s
Type Details Score
Publication
First Author: Martin MS
Year: 2007
Journal: Hum Mol Genet
Title: The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.
Volume: 16
Issue: 23
Pages: 2892-9
Publication  
First Author: Makinson CD
Year: 2014
Journal: Neurobiol Dis
Title: Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.
Volume: 68
Pages: 16-25
Publication
First Author: Lenk GM
Year: 2020
Journal: Ann Neurol
Title: Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.
Volume: 87
Issue: 3
Pages: 339-346
Publication
First Author: De Stasi AM
Year: 2016
Journal: Cereb Cortex
Title: Unaltered Network Activity and Interneuronal Firing During Spontaneous Cortical Dynamics In Vivo in a Mouse Model of Severe Myoclonic Epilepsy of Infancy.
Volume: 26
Issue: 4
Pages: 1778-94
Publication    
First Author: Mattis J
Year: 2022
Journal: Elife
Title: Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome.
Volume: 11
Publication  
First Author: Liebergall SR
Year: 2024
Journal: J Neurosci
Title: Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome.
Volume: 44
Issue: 17
Publication
First Author: Calhoun JD
Year: 2017
Journal: Epilepsia
Title: Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome.
Volume: 58
Issue: 8
Pages: e111-e115
Publication
First Author: Hawkins NA
Year: 2016
Journal: PLoS Genet
Title: Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq.
Volume: 12
Issue: 10
Pages: e1006398
Publication
First Author: Favero M
Year: 2018
Journal: J Neurosci
Title: A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome.
Volume: 38
Issue: 36
Pages: 7912-7927
Publication
First Author: Beretta S
Year: 2022
Journal: Mol Autism
Title: Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).
Volume: 13
Issue: 1
Pages: 1
Publication
First Author: Miljanovic N
Year: 2021
Journal: Epilepsia
Title: Metabolomic signature of the Dravet syndrome: A genetic mouse model study.
Volume: 62
Issue: 8
Pages: 2000-2014
Publication  
First Author: Miljanovic N
Year: 2021
Journal: Neurobiol Dis
Title: Proteomic signature of the Dravet syndrome in the genetic Scn1a-A1783V mouse model.
Volume: 157
Pages: 105423
Publication
First Author: Shapiro L
Year: 2019
Journal: Epilepsia
Title: Reduced cannabinoid 2 receptor activity increases susceptibility to induced seizures in mice.
Volume: 60
Issue: 12
Pages: 2359-2369
Publication  
First Author: Satta V
Year: 2020
Journal: Front Mol Neurosci
Title: Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments.
Volume: 13
Pages: 602801
Publication  
First Author: Alonso C
Year: 2022
Journal: Neuropharmacology
Title: Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome.
Volume: 205
Pages: 108914
Publication
First Author: Cheah CS
Year: 2019
Journal: J Neurosci
Title: Impairment of Sharp-Wave Ripples in a Murine Model of Dravet Syndrome.
Volume: 39
Issue: 46
Pages: 9251-9260
Publication
First Author: Papale LA
Year: 2013
Journal: Epilepsia
Title: Altered sleep regulation in a mouse model of SCN1A-derived genetic epilepsy with febrile seizures plus (GEFS+).
Volume: 54
Issue: 4
Pages: 625-34
Publication
First Author: Ogiwara I
Year: 2013
Journal: Hum Mol Genet
Title: Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.
Volume: 22
Issue: 23
Pages: 4784-804
Publication
First Author: Hawkins NA
Year: 2011
Journal: Neurobiol Dis
Title: Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.
Volume: 41
Issue: 3
Pages: 655-60
Publication
First Author: Voskobiynyk Y
Year: 2021
Journal: PLoS Genet
Title: Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.
Volume: 17
Issue: 1
Pages: e1009195
Publication
First Author: Yamagata T
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.
Volume: 491
Issue: 4
Pages: 1070-1076
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Yu FH
Year: 2006
Journal: Nat Neurosci
Title: Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.
Volume: 9
Issue: 9
Pages: 1142-9
Publication
First Author: Osteen JD
Year: 2016
Journal: Nature
Title: Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.
Volume: 534
Issue: 7608
Pages: 494-9
Publication
First Author: Jansen NA
Year: 2020
Journal: Epilepsia
Title: Focal and generalized seizure activity after local hippocampal or cortical ablation of NaV 1.1 channels in mice.
Volume: 61
Issue: 4
Pages: e30-e36
Publication  
First Author: Alonso C
Year: 2023
Journal: Neuropharmacology
Title: Disease-modifying effects of cannabidiol, β-caryophyllene and their combination in Syn1-Cre/Scn1a(WT/A1783V) mice, a preclinical model of Dravet syndrome.
Volume: 237
Pages: 109602
Publication  
First Author: Aiba I
Year: 2023
Journal: JCI Insight
Title: A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice.
Volume: 8
Issue: 15
Publication
First Author: Fadila S
Year: 2020
Journal: Epilepsia
Title: Convulsive seizures and some behavioral comorbidities are uncoupled in the Scn1aA1783V Dravet syndrome mouse model.
Volume: 61
Issue: 10
Pages: 2289-2300
Publication
First Author: Patra PH
Year: 2020
Journal: Br J Pharmacol
Title: Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice.
Volume: 177
Issue: 12
Pages: 2779-2792
Publication
First Author: Anderson LL
Year: 2014
Journal: Epilepsia
Title: Antiepileptic activity of preferential inhibitors of persistent sodium current.
Volume: 55
Issue: 8
Pages: 1274-83
Publication  
First Author: Mahadevan A
Year: 2022
Journal: Front Neurosci
Title: Xenon LFP Analysis Platform Is a Novel Graphical User Interface for Analysis of Local Field Potential From Large-Scale MEA Recordings.
Volume: 16
Pages: 904931
Publication  
First Author: Denomme N
Year: 2020
Journal: Neurosci Lett
Title: The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6.
Volume: 724
Pages: 134853
Publication  
First Author: Anderson LL
Year: 2022
Journal: Neuropharmacology
Title: The endocannabinoid system impacts seizures in a mouse model of Dravet syndrome.
Volume: 205
Pages: 108897
Publication  
First Author: Roberts NS
Year: 2023
Journal: Epilepsy Behav
Title: Anti-seizure efficacy of perampanel in two established rodent models of early-life epilepsy.
Volume: 143
Pages: 109194
Publication  
First Author: Yan WW
Year: 2021
Journal: eNeuro
Title: Enhanced Synaptic Transmission in the Extended Amygdala and Altered Excitability in an Extended Amygdala to Brainstem Circuit in a Dravet Syndrome Mouse Model.
Volume: 8
Issue: 3
Publication
First Author: Nomura T
Year: 2019
Journal: J Physiol
Title: Potentiating α2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet syndrome.
Volume: 597
Issue: 16
Pages: 4293-4307
Publication
First Author: Takado Y
Year: 2022
Journal: J Cereb Blood Flow Metab
Title: MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice.
Volume: 42
Issue: 1
Pages: 197-212
Publication
First Author: Kim Y
Year: 2018
Journal: J Clin Invest
Title: Severe peri-ictal respiratory dysfunction is common in Dravet syndrome.
Volume: 128
Issue: 3
Pages: 1141-1153
Publication  
First Author: Goisis RC
Year: 2022
Journal: Front Cell Neurosci
Title: GABA tonic currents and glial cells are altered during epileptogenesis in a mouse model of Dravet syndrome.
Volume: 16
Pages: 919493
Publication  
First Author: Rubinstein M
Year: 2015
Journal: Neurobiol Dis
Title: Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.
Volume: 73
Pages: 106-17
Publication  
First Author: Kalume F
Year: 2015
Journal: Neurobiol Dis
Title: Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.
Volume: 77
Pages: 141-54
Publication  
First Author: Cheah CS
Year: 2021
Journal: Front Cell Neurosci
Title: Sharp-Wave Ripple Frequency and Interictal Epileptic Discharges Increase in Tandem During Thermal Induction of Seizures in a Mouse Model of Genetic Epilepsy.
Volume: 15
Pages: 751762
Publication
First Author: Oakley JC
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy.
Volume: 106
Issue: 10
Pages: 3994-9
Publication
First Author: Richards KL
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.
Volume: 115
Issue: 34
Pages: E8077-E8085
Publication  
First Author: Uchino K
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Astrocyte Ca(2+) signaling is facilitated in Scn1a(+/-) mouse model of Dravet syndrome.
Volume: 643
Pages: 169-174
Publication
First Author: Cestèle S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Nonfunctional NaV1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects.
Volume: 110
Issue: 43
Pages: 17546-51
Publication
First Author: Jansen NA
Year: 2021
Journal: J Neurosci
Title: Impaired θ-γ Coupling Indicates Inhibitory Dysfunction and Seizure Risk in a Dravet Syndrome Mouse Model.
Volume: 41
Issue: 3
Pages: 524-537
Publication  
First Author: Arribas-Blázquez M
Year: 2021
Journal: Neuropharmacology
Title: Regulation of the voltage-dependent sodium channel Na(V)1.1 by AKT1.
Volume: 197
Pages: 108745
Publication
First Author: Duflocq A
Year: 2008
Journal: Mol Cell Neurosci
Title: Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments.
Volume: 39
Issue: 2
Pages: 180-92
GXD Expression    
Probe: MGI:3055546
Assay Type: RT-PCR
Annotation Date: 2004-10-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:3055554
Age: embryonic day 13.0
Image: 5
Specimen Label: Cx
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:3055546
Assay Type: RT-PCR
Annotation Date: 2004-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691021
Stage: TS21
Assay Id: MGI:3055554
Age: embryonic day 13.0
Image: 5
Specimen Label: H
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3707864
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610525
Stage: TS25
Assay Id: MGI:3708950
Age: embryonic day 17.5
Specimen Label: Fetus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3707864
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3708950
Age: postnatal day 1
Specimen Label: Neonate
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3707864
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Male
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3708950
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:3804461
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3804461
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804461
Age: postnatal day 9
Specimen Label: P9
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804461
Age: postnatal day 38
Specimen Label: P38
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804461
Age: postnatal day 76
Specimen Label: P76
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804461
Age: postnatal day 126
Specimen Label: P126
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:3804474
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3804474
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804474
Age: postnatal day 9
Specimen Label: P9
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804474
Age: postnatal day 38
Specimen Label: P38
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804474
Age: postnatal day 76
Specimen Label: P76
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804474
Age: postnatal day 126
Specimen Label: P126
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3804483
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804639
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804649
Age: postnatal day 76
Specimen Label: H
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804652
Age: postnatal day 76
Specimen Label: H
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715728
Stage: TS28
Assay Id: MGI:3804649
Age: postnatal day 76
Specimen Label: G
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715728
Stage: TS28
Assay Id: MGI:3804652
Age: postnatal day 76
Specimen Label: G
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3804403
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1857728
Stage: TS28
Assay Id: MGI:3804649
Age: postnatal day 76
Specimen Label: N
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3804411
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1857728
Stage: TS28
Assay Id: MGI:3804652
Age: postnatal day 76
Specimen Label: N
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1614747
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1603911
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:3828772
Age: embryonic day 7.5
Image: E7.5
Note: Expression is weak to non-existent.
Specimen Label: E7.5
Specimen Num: 1
GXD Expression  
Probe: MGI:1614747
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3828772
Age: embryonic day 8.5
Image: E8.5
Note: Expression is weak to non-existent.
Specimen Label: E8.5
Specimen Num: 2
GXD Expression  
Probe: MGI:6182849
Assay Type: RNA in situ
Annotation Date: 2023-11-28
Strength: Present
Sex: Male
Emaps: EMAPS:3583128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7561848
Age: postnatal day 56
Image: S3
Specimen Label: S3
Detected: true
Specimen Num: 1
Publication    
First Author: Jover E
Year: 1995
Journal: GenBank Submission
Title: Mus musculus sodium channel 3 mRNA, complete cds
Pages: L42339
Publication
First Author: Planells-Cases R
Year: 2000
Journal: Biophys J
Title: Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.
Volume: 78
Issue: 6
Pages: 2878-91
Publication
First Author: Xu D
Year: 2018
Journal: J Exp Med
Title: Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy.
Volume: 215
Issue: 4
Pages: 1169-1186
Publication  
First Author: Hawkins NA
Year: 2016
Journal: Epilepsy Res
Title: Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations.
Volume: 119
Pages: 20-3
Publication
First Author: Tran CH
Year: 2020
Journal: J Neurosci
Title: Interneuron Desynchronization Precedes Seizures in a Mouse Model of Dravet Syndrome.
Volume: 40
Issue: 13
Pages: 2764-2775
Publication
First Author: Kaplan JS
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.
Volume: 114
Issue: 42
Pages: 11229-11234