This entry represents replication factor C subunit 1 (RFC1), which is the large subunit of replication factor C (RF-C), a five subunit DNA polymerase accessory protein. RF-C is a DNA binding protein complex and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon []. It also may have a role in telomere stability [].
This is the C-terminal domain of replication factor C, RFC1. RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo [, ].
