The Caskin1 protein interacts with the CASK protein via this region []. CASK and Caskin1 are synaptic scaffolding proteins. The binding motif on human Caskin1 is EEIWVLRK. A similar motif is found on protein MINT1 and protein TIAM1, both shown to be able to bind to CASK though the motif. However, MINT1 and TIAM1 are not included in this entry []. This region is predicted to be natively unstructured.This entry also matches Caskin2, a Caskin1 homologue deprived of the CASK interaction domain (CID) []. Caskin1 and caskin2 consist of multiple ankyrin repeats, two SAM domains and one SH3 domain. In Caskin1 the CID is located between the SH3 and SAM domains [].
