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Search results 201 to 300 out of 427 for Irs2

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_12
Specimen Label: euxassay_014216_12
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_13
Specimen Label: euxassay_014216_13
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1811823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_08
Specimen Label: euxassay_014216_08
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1811823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_21
Specimen Label: euxassay_014216_21
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1811823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_22
Specimen Label: euxassay_014216_22
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_06
Specimen Label: euxassay_014216_06
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_18
Specimen Label: euxassay_014216_18
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1790923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_09
Specimen Label: euxassay_014216_09
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1790923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_10
Specimen Label: euxassay_014216_10
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1790923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_11
Specimen Label: euxassay_014216_11
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1790923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_12
Specimen Label: euxassay_014216_12
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1790923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_14
Specimen Label: euxassay_014216_14
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1790923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_15
Specimen Label: euxassay_014216_15
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1790923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_16
Specimen Label: euxassay_014216_16
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1804223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_13
Specimen Label: euxassay_014216_13
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1804223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_14
Specimen Label: euxassay_014216_14
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1804223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_15
Specimen Label: euxassay_014216_15
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1804223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_16
Specimen Label: euxassay_014216_16
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1812323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_22
Specimen Label: euxassay_014216_22
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1811323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_07
Specimen Label: euxassay_014216_07
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1811323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_08
Specimen Label: euxassay_014216_08
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1811323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_21
Specimen Label: euxassay_014216_21
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1811323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_22
Specimen Label: euxassay_014216_22
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_11
Specimen Label: euxassay_014216_11
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_12
Specimen Label: euxassay_014216_12
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_14
Specimen Label: euxassay_014216_14
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825620
Age: embryonic day 14.5
Image: euxassay_014216_15
Specimen Label: euxassay_014216_15
Detected: true
Specimen Num: 13
•
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•
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Publication
- | J:66046
   
First Author: Xu G
Year: 1998
Journal: GenBank Submission
Title: Mus musculus insulin receptor substrate-2 (Irs2) gene, partial cds
Pages: AF090738
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Publication
28833887 | J:251043
First Author: Chirivella L
Year: 2017
Journal: Stem Cells
Title: Cyclin-Dependent Kinase 4 Regulates Adult Neural Stem Cell Proliferation and Differentiation in Response to Insulin.
Volume: 35
Issue: 12
Pages: 2403-2416
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Publication
23702782 | J:214039
First Author: Arroba AI
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice.
Volume: 54
Issue: 6
Pages: 4215-25
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Publication
14755338 | J:87590
First Author: Asilmaz E
Year: 2004
Journal: J Clin Invest
Title: Site and mechanism of leptin action in a rodent form of congenital lipodystrophy.
Volume: 113
Issue: 3
Pages: 414-24
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Publication
16774126 | J:145064
First Author: Hashimoto H
Year: 2006
Journal: Comp Med
Title: Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2.
Volume: 56
Issue: 3
Pages: 176-87
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Publication
24517226 | J:210484
First Author: Togashi Y
Year: 2014
Journal: Endocrinology
Title: β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.
Volume: 155
Issue: 5
Pages: 1643-52
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Publication
24712877 | J:213137
First Author: Shirakawa J
Year: 2014
Journal: Endocrinology
Title: Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β-cell functions, and β-cell proliferation in male mice.
Volume: 155
Issue: 6
Pages: 2102-11
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Publication
15550388 | J:96977
First Author: Suzuki R
Year: 2005
Journal: J Biol Chem
Title: Expression of DGAT2 in white adipose tissue is regulated by central leptin action.
Volume: 280
Issue: 5
Pages: 3331-7
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Publication
7675087 | J:38317
First Author: Sun XJ
Year: 1995
Journal: Nature
Title: Role of IRS-2 in insulin and cytokine signalling.
Volume: 377
Issue: 6545
Pages: 173-7
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Publication
17901049 | J:128457
First Author: Zhang J
Year: 2007
Journal: J Biol Chem
Title: The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation.
Volume: 282
Issue: 47
Pages: 34356-64
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Publication
9495343 | J:46134
First Author: Withers DJ
Year: 1998
Journal: Nature
Title: Disruption of IRS-2 causes type 2 diabetes in mice.
Volume: 391
Issue: 6670
Pages: 900-4
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Publication
17928362 | J:134916
First Author: Selman C
Year: 2008
Journal: FASEB J
Title: Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
Volume: 22
Issue: 3
Pages: 807-18
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Publication
26022372 | J:233930
First Author: Vinué Á
Year: 2015
Journal: Biochim Biophys Acta
Title: Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling.
Volume: 1852
Issue: 9
Pages: 1729-42
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Publication
28003360 | J:240715
First Author: Xi G
Year: 2017
Journal: J Biol Chem
Title: Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.
Volume: 292
Issue: 5
Pages: 2009-2020
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Publication
11078455 | J:65485
First Author: Kubota N
Year: 2000
Journal: Diabetes
Title: Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Volume: 49
Issue: 11
Pages: 1880-9
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Publication
11546755 | J:132899
First Author: Tobe K
Year: 2001
Journal: J Biol Chem
Title: Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.
Volume: 276
Issue: 42
Pages: 38337-40
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Publication
14736890 | J:89532
First Author: Shimoaka T
Year: 2004
Journal: J Biol Chem
Title: Impairment of bone healing by insulin receptor substrate-1 deficiency.
Volume: 279
Issue: 15
Pages: 15314-22
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Publication
12810606 | J:99746
First Author: Kubota T
Year: 2003
Journal: Circulation
Title: Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.
Volume: 107
Issue: 24
Pages: 3073-80
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Publication
11259600 | J:68004
First Author: Miki H
Year: 2001
Journal: Mol Cell Biol
Title: Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.
Volume: 21
Issue: 7
Pages: 2521-32
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Publication
22688336 | J:208534
First Author: Wang Z
Year: 2012
Journal: Diabetes
Title: Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
Volume: 61
Issue: 8
Pages: 2134-45
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Publication
28190325 | J:273780
First Author: Tang CY
Year: 2017
Journal: Mol Cells
Title: IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33.
Volume: 40
Issue: 2
Pages: 123-132
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Publication
12746333 | J:83689
First Author: Lee AV
Year: 2003
Journal: Endocrinology
Title: Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.
Volume: 144
Issue: 6
Pages: 2683-94
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Publication
10801879 | J:63655
First Author: Poltilove RM
Year: 2000
Journal: J Biol Chem
Title: Characterization of Drosophila insulin receptor substrate.
Volume: 275
Issue: 30
Pages: 23346-54
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Publication
34537327 | J:318654
 
First Author: Ochiai T
Year: 2021
Journal: Neurobiol Dis
Title: Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.
Volume: 159
Pages: 105510
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Publication
18288891 | J:135659
First Author: Tanabe K
Year: 2008
Journal: PLoS Biol
Title: Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
Volume: 6
Issue: 2
Pages: e37
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Publication
11018022 | J:66427
First Author: Farhang-Fallah J
Year: 2000
Journal: J Biol Chem
Title: Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein.
Volume: 275
Issue: 51
Pages: 40492-7
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Publication
17636024 | J:125126
First Author: Podcheko A
Year: 2007
Journal: Mol Cell Biol
Title: Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival.
Volume: 27
Issue: 18
Pages: 6484-96
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Publication
22210743 | J:182437
First Author: Burgos-Ramos E
Year: 2012
Journal: Endocrinology
Title: Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.
Volume: 153
Issue: 3
Pages: 1129-40
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Publication
16154098 | J:129682
First Author: Kitamura YI
Year: 2005
Journal: Cell Metab
Title: FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Volume: 2
Issue: 3
Pages: 153-63
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Publication
10642598 | J:59431
First Author: Kido Y
Year: 2000
Journal: J Clin Invest
Title: Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
Volume: 105
Issue: 2
Pages: 199-205
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Publication
33761350 | J:304286
First Author: Stöhr O
Year: 2021
Journal: Cell Rep
Title: FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.
Volume: 34
Issue: 12
Pages: 108893
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Publication
16750510 | J:110785
First Author: Sobel BE
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Insulin resistance increases PAI-1 in the heart.
Volume: 346
Issue: 1
Pages: 102-7
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Publication
10949029 | J:63895
First Author: Shimomura I
Year: 2000
Journal: Mol Cell
Title: Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.
Volume: 6
Issue: 1
Pages: 77-86
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Publication
12869553 | J:128796
First Author: Suzuki R
Year: 2003
Journal: J Biol Chem
Title: Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
Volume: 278
Issue: 44
Pages: 43691-8
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Publication
19542202 | J:154405
First Author: Morris DL
Year: 2009
Journal: Diabetes
Title: SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.
Volume: 58
Issue: 9
Pages: 2039-47
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Publication
23940800 | J:205902
First Author: Tao R
Year: 2013
Journal: PLoS One
Title: Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.
Volume: 8
Issue: 8
Pages: e71997
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Publication
30532187 | J:269453
First Author: Kalvisa A
Year: 2018
Journal: PLoS Biol
Title: Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.
Volume: 16
Issue: 12
Pages: e2006249
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Publication
15821749 | J:98318
First Author: Bard-Chapeau EA
Year: 2005
Journal: Nat Med
Title: Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action.
Volume: 11
Issue: 5
Pages: 567-71
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Publication
25569103 | J:235113
 
First Author: Liu L
Year: 2015
Journal: Cell Death Dis
Title: Tamoxifen reduces fat mass by boosting reactive oxygen species.
Volume: 6
Pages: e1586
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Publication
8649419 | J:110842
First Author: Yamauchi T
Year: 1996
Journal: Mol Cell Biol
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