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Search results 301 to 344 out of 344 for Rack1

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0.041s

Type

Details

Score

Publication

21098678 | -

First Author:	Guo J
Year:	2011
Journal:	Plant Physiol
Title:	Involvement of Arabidopsis RACK1 in protein translation and its regulation by abscisic acid.
Volume:	155
Issue:	1
Pages:	370-83

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Publication

28245531 | -

First Author:	Kershner L
Year:	2017
Journal:	Dev Neurobiol
Title:	RACK1 is necessary for the formation of point contacts and regulates axon growth.
Volume:	77
Issue:	9
Pages:	1038-1056

•

Publication

24726876 | J:209955

First Author:	Long L
Year:	2014
Journal:	Immunity
Title:	Recruitment of phosphatase PP2A by RACK1 adaptor protein deactivates transcription factor IRF3 and limits type I interferon signaling.
Volume:	40
Issue:	4
Pages:	515-29

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Publication

11279199 | -

First Author:	Chang BY
Year:	2001
Journal:	J Biol Chem
Title:	The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1.
Volume:	276
Issue:	23
Pages:	20346-56

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Interaction Experiment

Dell EJ (2002)

Description:

The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.

•

Interaction Experiment

Cao J (2019)

Description:

RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog.

•

GO Term

GO:1990630 | IRE1-RACK1-PP2A complex

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Allele

Rack1<tm1Smoc> | MGI:7291959

Name:	receptor for activated C kinase 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type:	Targeted
Attribute String:	Conditional ready, No functional change

•

Publication

28132843 | -

First Author:	Sundaramoorthy E
Year:	2017
Journal:	Mol Cell
Title:	ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation.
Volume:	65
Issue:	4
Pages:	751-760.e4

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Publication

12359736 | -

First Author:	Dell EJ
Year:	2002
Journal:	J Biol Chem
Title:	The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.
Volume:	277
Issue:	51
Pages:	49888-95

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Publication

30809310 | -

First Author:	Cao J
Year:	2019
Journal:	Theranostics
Title:	RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog.
Volume:	9
Issue:	3
Pages:	811-828

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Publication

14699138 | -

First Author:	Nery FC
Year:	2004
Journal:	J Biol Chem
Title:	Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.
Volume:	279
Issue:	12
Pages:	11444-55

•

Publication

17502419 | -

First Author:	Gaboreanu AM
Year:	2007
Journal:	J Cell Biol
Title:	Myelin protein zero/P0 phosphorylation and function require an adaptor protein linking it to RACK1 and PKC alpha.
Volume:	177
Issue:	4
Pages:	707-16

•

Publication

30012863 | -

First Author:	Dobrikov MI
Year:	2018
Journal:	Mol Cell Biol
Title:	Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.
Volume:	38
Issue:	19

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Protein Domain

IPR045223 | Asc1/RACK1

Type:

Family

Description:

This entry includes Asc1 from yeasts and RACK1 from animals. They are core 40S ribosomal proteins that repress gene expression []. The seven-bladed β-propeller structure of RACK1 is located near the mRNA exit tunnel where it makes contacts with the ribosomal RNA through lysine and arginine residues and neighbouring ribosomal proteins []. RACK1 also serves as a scaffold protein for a wide range of kinases and membrane bound receptors [, ]. It has been shown to regulates axonal growth []and is essential for development in mice, Drosophila melanogaster and Arabidopsis thaliana [, , ].

•

Publication

10206977 | J:54867

First Author:	Wood LC
Year:	1999
Journal:	J Biol Chem
Title:	Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae.
Volume:	274
Issue:	17
Pages:	11653-9

•

Protein

O55135

Organism:	Mus musculus/domesticus
Length:	245
Fragment?:	false

•

Protein

Q9R071

Organism:	Mus musculus/domesticus
Length:	245
Fragment?:	false

•

Protein

Q545K4

Organism:	Mus musculus/domesticus
Length:	245
Fragment?:	false

•

Protein

Q3U818

Organism:	Mus musculus/domesticus
Length:	245
Fragment?:	false

•

Protein

A6PWZ2

Organism:	Mus musculus/domesticus
Length:	58
Fragment?:	true

•

Protein

Q3UA13

Organism:	Mus musculus/domesticus
Length:	245
Fragment?:	false

•

Protein

Q3U740

Organism:	Mus musculus/domesticus
Length:	245
Fragment?:	false

•

Protein

B1AZQ4

Organism:	Mus musculus/domesticus
Length:	81
Fragment?:	false

•

Protein

Q3UBJ6

Organism:	Mus musculus/domesticus
Length:	245
Fragment?:	false

•

Protein

D6RJJ3

Organism:	Mus musculus/domesticus
Length:	71
Fragment?:	false

•

Publication

9891075 | -

First Author:	Si K
Year:	1999
Journal:	Mol Cell Biol
Title:	The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor.
Volume:	19
Issue:	2
Pages:	1416-26

•

Publication

11238882 | -

First Author:	Basu U
Year:	2001
Journal:	Mol Cell Biol
Title:	The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis.
Volume:	21
Issue:	5
Pages:	1453-62

•

Publication

9405604 | -

First Author:	Si K
Year:	1997
Journal:	Proc Natl Acad Sci U S A
Title:	Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6.
Volume:	94
Issue:	26
Pages:	14285-90

•

Publication

11524672 | -

First Author:	Paoli M
Year:	2001
Journal:	Nat Struct Biol
Title:	An elusive propeller-like fold.
Volume:	8
Issue:	9
Pages:	744-5

•

Protein Domain

IPR002769 | eIF6

Type:

Family

Description:

This family includes eukaryotic translation initiation factor 6 (eIF6) as well as presumed archaeal homologues.The assembly of 80S ribosomes requires joining of the 40S and 60S subunits, which is triggered by the formation of an initiation complex on the 40S subunit. This event is rate-limiting for translation, and depends on external stimuli and the status of the cell. Eukaryotic translation initiation factor 6 (eIF6) binds specifically to the free 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit ribosomes []. Furthermore, eIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C (PKC). RACK1 is a major component of translating ribosomes, which harbour significant amounts of PKC. Loading 60S subunits with eIF6 caused a dose-dependent translational block and impairment of 80S formation, which are reversed by expression of RACK1 and stimulation of PKC in vivo and in vitro. PKC stimulation leads to eIF6 phosphorylation and its release, promoting 80S subunit formation. RACK1 provides a physical and functional link between PKC signalling and ribosome activation [, , ].All members of this family have a conserved pentameric fold referred to as a beta/alpha propeller. The eukaryotic IF6 members have a moderately conserved C-terminal extension which is not required for ribosomal binding, and may have an alternative function [].

•

Protein Domain

IPR026250 | ITPRIP_fam

Type:

Family

Description:

The inositol 1,4,5-trisphosphate receptor (IP(3)R) is a large, endoplasmic reticulum (ER)-resident protein that is a key regulator of intracellular Ca(2+) signalling []. Inositol 1,4,5-trisphosphate is formed in response to the activation of G protein-coupled receptors or tyrosine kinase receptors located in the plasma membrane, which elicit IP(3)R-mediated Ca(2+) release from ER stores [].The IP(3)R contains an N-terminal IP(3) recognition site and a C-terminal Ca(2+)-channel domain; between them is a large interaction domain for regulatory proteins, including calmodulin, chromgranins, glyceraldehyde-3- phosphate dehydrogenase, RACK1 and caldendrin []. These proteins regulate IP(3)R in diverse ways, but only two regulators have been shown to influence Ca(2+) sensitivity [].A protein termed DANGER has been identified as a novel IP(3)R-interacting protein []. DANGER is membrane-associated and predicted to contain a partial MAB-21 domain. It is expressed in a wide variety of neuronal cell lineages, where it localises with IP(3)R to membranes in the cell periphery. DANGER interacts with IP(3)R in vitro and co-immuno- precipitates with IP(3)R from cellular preparations; it robustly enhances Ca(2+)-mediated inhibition of IP(3)R Ca(2+) release without affecting IP(3) binding in microsomal assays, and inhibits gating in single-channel recordings of IP(3)R. The protein appears to allosterically modulate the sensitivity of IP(3)R to Ca(2+) inhibition, which probably alters IP(3)R-mediated Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed [].

•

Publication

19917775 | J:154974

First Author:	Knezevic N
Year:	2009
Journal:	J Exp Med
Title:	The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.
Volume:	206
Issue:	12
Pages:	2761-77

•

Publication

24584330 | J:225232

First Author:	Leggio GM
Year:	2014
Journal:	Neuropsychopharmacology
Title:	Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone.
Volume:	39
Issue:	8
Pages:	2017-28

•

Publication

23874892 | J:204393

First Author:	Kurabayashi A
Year:	2013
Journal:	PLoS One
Title:	Conditional VHL gene deletion causes hypoglycemic death associated with disproportionately increased glucose uptake by hepatocytes through an upregulated IGF-I receptor.
Volume:	8
Issue:	7
Pages:	e69139

•

Publication

24624118 | J:312013

First Author:	Ozoe A
Year:	2014
Journal:	Front Endocrinol (Lausanne)
Title:	Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis.
Volume:	5

Pages:	24

•

Publication

16380450 | J:131240

First Author:	Pick M
Year:	2006
Journal:	Blood
Title:	Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis.
Volume:	107
Issue:	8
Pages:	3397-406

•

Publication

20074551 | J:157863

First Author:	Charlton HK
Year:	2010
Journal:	Biochem Biophys Res Commun
Title:	ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling.
Volume:	392
Issue:	2
Pages:	234-9

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Protein Coding Gene

MGI:1930134 | Ern1

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

P68040

Organism:	Mus musculus/domesticus
Length:	317
Fragment?:	false

•

Protein

Q3TNL8

Organism:	Mus musculus/domesticus
Length:	555
Fragment?:	false

•

Protein

A2ASA8

Organism:	Mus musculus/domesticus
Length:	547
Fragment?:	false

•

Protein

Q3UV16

Organism:	Mus musculus/domesticus
Length:	535
Fragment?:	false

•

Publication

16990268 | J:118203

First Author:	van Rossum DB
Year:	2006
Journal:	J Biol Chem
Title:	DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity.
Volume:	281
Issue:	48
Pages:	37111-6

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