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Search results 301 to 328 out of 328 for Fto

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0.023s

Type

Details

Score

Protein Domain

IPR024366 | FTO_C

Type:

Domain

Description:

Alpha-ketoglutarate-dependent dioxygenase FTO, also known as Fat mass and obesity-associated protein, is a nucleus protein which belongs to the FTO family. This enzyme is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation []. FTO activity is highest towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. FTO has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine [], ]. FTO has no activity towards 1-methylguanine. It has no detectable activity towards double-stranded DNA. FTO requires molecular oxygen, alpha-ketoglutarate and iron. FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. It contributes to the regulation of body size and body fat accumulation as well [].FTO contains two well-defined domains: an N- (residues 32-326) and a C- (residues 327-498) terminal domain. The N-terminal domain of this protein is a DNA demethylase []. This entry represents the C-terminal domain (CTD). This domain is α-helical with α7, α8 and α10 forming a three-helix bundle. One end of the helix bundle interacts with the N-terminal domain of FTO, and it has been suggested that the CTD plays a role in stabilising the NTD's conformation since the NTD only exhibits enzymatic activity when co-expressed with the CTD [].

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Genotype

Symbol:	Emx1/Emx1<+> Fto/Fto
Background:	involves: 129S2/SvPas * C57BL/6J
Zygosity:	cn
Has Mutant Allele:	true

•

Allele

Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc> | MGI:4879001

Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Roger D Cox
Allele Type:	Targeted
Attribute String:	Inserted expressed sequence, Reporter

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Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background:	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background:	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Zygosity:	hm
Has Mutant Allele:	true

•

HT Experiment

GSE154992 | Combined analysis of ribo-seq and rna-seq reveals that Mettl3 regulates embryonic cerebral cortex development in mice by controlling the proliferation and differentiation of neural progenitor cells


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

Genotype

Symbol:	Fto/Fto Speer6-ps1/Speer6-ps1<+>
Background:	involves: C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

16174769 | J:104108

First Author:	Lee DH
Year:	2005
Journal:	J Biol Chem
Title:	Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.
Volume:	280
Issue:	47
Pages:	39448-59

•

Publication

23572141 | J:198968

First Author:	Solberg A
Year:	2013
Journal:	J Mol Cell Biol
Title:	Deletion of mouse Alkbh7 leads to obesity.
Volume:	5
Issue:	3
Pages:	194-203

•

Publication

23666923 | -

First Author:	Fu D
Year:	2013
Journal:	Genes Dev
Title:	Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis.
Volume:	27
Issue:	10
Pages:	1089-100

•

Publication

25122757 | -

First Author:	Wang G
Year:	2014
Journal:	J Biol Chem
Title:	The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism.
Volume:	289
Issue:	40
Pages:	27924-36

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Protein Domain

IPR032870 | ALKBH7

Type:

Family

Description:

Nine mammalian AlkB homologues exist, ALKBH1-8 and FTO [, ]. Differently to other AlkB homologues, AlkB homologue 7 (ALKBH7) does not exhibit any demethylase activity in DNA or RNA []and its substrate is still unknown []. ALKBH7 is located in the mitochondrial matrix. It is a key protein for programmed necrosis and fat metabolism [, , ]. After agent-induced DNA-damage, it triggers the collapse of mitochondrial membrane potential and large-scale loss of mitochondrial function that lead to energy depletion and cellular demise [].

•

Publication

33220174 | J:300512

First Author:	Du J
Year:	2020
Journal:	Dev Cell
Title:	N⁶-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Volume:	55
Issue:	6
Pages:	737-753.e7

•

Publication

31037292 | J:294398

First Author:	Song T
Year:	2019
Journal:	Nucleic Acids Res
Title:	Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.
Volume:	47
Issue:	12
Pages:	6130-6144

•

Publication

34083488 | J:311509

First Author:	Sobreira DR
Year:	2021
Journal:	Science
Title:	Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Volume:	372
Issue:	6546
Pages:	1085-1091

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Protein

Q9D6Z0

Organism:	Mus musculus/domesticus
Length:	221
Fragment?:	false

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Publication

17241623 | J:134435

First Author:	Anselme I
Year:	2007
Journal:	Dev Biol
Title:	Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes.
Volume:	304
Issue:	1
Pages:	208-20

•

Publication

29466054 | J:267915

First Author:	Carli JFM
Year:	2018
Journal:	FASEB J
Title:	The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function.
Volume:	32
Issue:	7
Pages:	3946-3956

•

Publication

30538277 | J:280171

First Author:	Bjune JI
Year:	2019
Journal:	Int J Obes (Lond)
Title:	IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.
Volume:	43
Issue:	11
Pages:	2151-2162

•

Publication

24488767 | J:210677

First Author:	Lin L
Year:	2014
Journal:	Hum Mol Genet
Title:	Fat mass and obesity-associated (FTO) protein interacts with CaMKII and modulates the activity of CREB signaling pathway.
Volume:	23
Issue:	12
Pages:	3299-306

•

Publication

28724990 | J:251732

First Author:	Zillikens MC
Year:	2017
Journal:	Nat Commun
Title:	Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Volume:	8
Issue:	1
Pages:	80

•

Publication

29777057 | J:267135

First Author:	Faulds KJ
Year:	2018
Journal:	J Biol Chem
Title:	Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells.
Volume:	293
Issue:	27
Pages:	10731-10743

•

Publication

36115924 | J:334589

First Author:	Son JE
Year:	2022
Journal:	Int J Obes (Lond)
Title:	Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities.
Volume:	46
Issue:	11
Pages:	2029-2039

•

Publication

30319684 | J:303159

First Author:	Mulligan MK
Year:	2018
Journal:	Front Genet
Title:	Genetic Contribution to Initial and Progressive Alcohol Intake Among Recombinant Inbred Strains of Mice.
Volume:	9

Pages:	370

•

Publication

34657574 | J:326443

First Author:	Liang D
Year:	2022
Journal:	Autophagy
Title:	m⁶A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Volume:	18
Issue:	6
Pages:	1318-1337

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

•

Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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