Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Zhu QS |
Year: |
1990 |
Journal: |
Nucleic Acids Res |
Title: |
Unique organization of the human BCR gene promoter. |
Volume: |
18 |
Issue: |
23 |
Pages: |
7119-25 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
46
|
Fragment?: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
BCR activator of RhoGEF and GTPase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Ubelhart R |
Year: |
2010 |
Journal: |
Nat Immunol |
Title: |
N-linked glycosylation selectively regulates autonomous precursor BCR function. |
Volume: |
11 |
Issue: |
8 |
Pages: |
759-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuo PY |
Year: |
2018 |
Journal: |
Blood |
Title: |
SOX11 augments BCR signaling to drive MCL-like tumor development. |
Volume: |
131 |
Issue: |
20 |
Pages: |
2247-2255 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poe JC |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
EndoU is a novel regulator of AICD during peripheral B cell selection. |
Volume: |
211 |
Issue: |
1 |
Pages: |
57-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Minguet S |
Year: |
2017 |
Journal: |
Nat Immunol |
Title: |
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1150-1159 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang CA |
Year: |
2021 |
Journal: |
Cell Mol Immunol |
Title: |
STING regulates BCR signaling in normal and malignant B cells. |
Volume: |
18 |
Issue: |
4 |
Pages: |
1016-1031 |
|
•
•
•
•
•
|
Publication |
First Author: |
Minguet S |
Year: |
2008 |
Journal: |
Eur J Immunol |
Title: |
Enhanced B-cell activation mediated by TLR4 and BCR crosstalk. |
Volume: |
38 |
Issue: |
9 |
Pages: |
2475-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Avalos AM |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. |
Volume: |
211 |
Issue: |
2 |
Pages: |
365-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du Z |
Year: |
2020 |
Journal: |
Cell Commun Signal |
Title: |
AKT2 deficiency impairs formation of the BCR signalosome. |
Volume: |
18 |
Issue: |
1 |
Pages: |
56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen H |
Year: |
2020 |
Journal: |
Nature |
Title: |
BCR selection and affinity maturation in Peyer's patch germinal centres. |
Volume: |
582 |
Issue: |
7812 |
Pages: |
421-425 |
|
•
•
•
•
•
|
Allele |
Name: |
BCR activator of RhoGEF and GTPase; targeted mutation 1, Theodora S Ross |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bolger-Munro M |
Year: |
2019 |
Journal: |
Elife |
Title: |
Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation. |
Volume: |
8 |
|
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Yam-Puc JC |
Year: |
2021 |
Journal: |
iScience |
Title: |
Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death. |
Volume: |
24 |
Issue: |
2 |
Pages: |
102038 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ulivieri C |
Year: |
2003 |
Journal: |
Eur J Immunol |
Title: |
Normal B-1 cell development but defective BCR signaling in Lck-/- mice. |
Volume: |
33 |
Issue: |
2 |
Pages: |
441-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Łyszkiewicz M |
Year: |
2019 |
Journal: |
Front Immunol |
Title: |
LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking. |
Volume: |
10 |
|
Pages: |
497 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang C |
Year: |
2019 |
Journal: |
EBioMedicine |
Title: |
Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response. |
Volume: |
45 |
|
Pages: |
578-587 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amin R |
Year: |
2014 |
Journal: |
Oncotarget |
Title: |
The class-specific BCR tonic signal modulates lymphomagenesis in a c-myc deregulation transgenic model. |
Volume: |
5 |
Issue: |
19 |
Pages: |
8995-9006 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murn J |
Year: |
2009 |
Journal: |
BMC Genomics |
Title: |
A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering. |
Volume: |
10 |
|
Pages: |
323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Torres RM |
Year: |
1996 |
Journal: |
Science |
Title: |
Aberrant B cell development and immune response in mice with a compromised BCR complex. |
Volume: |
272 |
Issue: |
5269 |
Pages: |
1804-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su TT |
Year: |
2002 |
Journal: |
Nat Immunol |
Title: |
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. |
Volume: |
3 |
Issue: |
8 |
Pages: |
780-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castello A |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. |
Volume: |
14 |
Issue: |
9 |
Pages: |
966-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen TT |
Year: |
2017 |
Journal: |
Nat Immunol |
Title: |
The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR. |
Volume: |
18 |
Issue: |
3 |
Pages: |
321-333 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kraus M |
Year: |
2004 |
Journal: |
Cell |
Title: |
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. |
Volume: |
117 |
Issue: |
6 |
Pages: |
787-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kometani K |
Year: |
2011 |
Journal: |
J Exp Med |
Title: |
CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway. |
Volume: |
208 |
Issue: |
7 |
Pages: |
1447-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Capasso M |
Year: |
2010 |
Journal: |
Nat Immunol |
Title: |
HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. |
Volume: |
11 |
Issue: |
3 |
Pages: |
265-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsiantoulas D |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development. |
Volume: |
7 |
Issue: |
1 |
Pages: |
3540 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gasparrini F |
Year: |
2016 |
Journal: |
EMBO J |
Title: |
Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling. |
Volume: |
35 |
Issue: |
3 |
Pages: |
258-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Avramidou A |
Year: |
2007 |
Journal: |
Cell Death Differ |
Title: |
The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis. |
Volume: |
14 |
Issue: |
11 |
Pages: |
1936-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sacquin A |
Year: |
2017 |
Journal: |
Eur J Immunol |
Title: |
The strength of BCR signaling shapes terminal development of follicular helper T cells in mice. |
Volume: |
47 |
Issue: |
8 |
Pages: |
1295-1304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2014 |
Journal: |
Int Immunol |
Title: |
A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells. |
Volume: |
26 |
Issue: |
1 |
Pages: |
47-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gross AJ |
Year: |
2011 |
Journal: |
Eur J Immunol |
Title: |
Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. |
Volume: |
41 |
Issue: |
12 |
Pages: |
3645-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rowland SL |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation. |
Volume: |
207 |
Issue: |
3 |
Pages: |
607-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li N |
Year: |
2020 |
Journal: |
Cell Mol Life Sci |
Title: |
CX3CR1 positively regulates BCR signaling coupled with cell metabolism via negatively controlling actin remodeling. |
Volume: |
77 |
Issue: |
21 |
Pages: |
4379-4395 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zou X |
Year: |
2001 |
Journal: |
Int Immunol |
Title: |
Truncation of the mu heavy chain alters BCR signalling and allows recruitment of CD5+ B cells. |
Volume: |
13 |
Issue: |
12 |
Pages: |
1489-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heisterkamp N |
Year: |
2001 |
Journal: |
Int J Mol Med |
Title: |
The Bcr N-terminal oligomerization domain contributes to the full oncogenicity of P190 Bcr/Abl in transgenic mice. |
Volume: |
7 |
Issue: |
4 |
Pages: |
351-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu X |
Year: |
2008 |
Journal: |
Eur J Immunol |
Title: |
Transgenic expression of Spi-C impairs B-cell development and function by affecting genes associated with BCR signaling. |
Volume: |
38 |
Issue: |
9 |
Pages: |
2587-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmidt C |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright. |
Volume: |
28 |
Issue: |
6 |
Pages: |
711-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrews SF |
Year: |
2012 |
Journal: |
Eur J Immunol |
Title: |
Developmentally regulated expression of MEF2C limits the response to BCR engagement in transitional B cells. |
Volume: |
42 |
Issue: |
5 |
Pages: |
1327-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yi SJ |
Year: |
2011 |
Journal: |
BMC Biochem |
Title: |
Bcr is a substrate for Transglutaminase 2 cross-linking activity. |
Volume: |
12 |
|
Pages: |
8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shih TA |
Year: |
2002 |
Journal: |
Nat Immunol |
Title: |
Role of BCR affinity in T cell dependent antibody responses in vivo. |
Volume: |
3 |
Issue: |
6 |
Pages: |
570-5 |
|
•
•
•
•
•
|
Pathway |
|
•
•
•
•
•
|
Publication |
First Author: |
Cicchetti P |
Year: |
1992 |
Journal: |
Science |
Title: |
Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. |
Volume: |
257 |
Issue: |
5071 |
Pages: |
803-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cornall RJ |
Year: |
1998 |
Journal: |
Immunity |
Title: |
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. |
Volume: |
8 |
Issue: |
4 |
Pages: |
497-508 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller AT |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction. |
Volume: |
182 |
Issue: |
8 |
Pages: |
4696-704 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kreslavsky T |
Year: |
2017 |
Journal: |
Nat Immunol |
Title: |
Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. |
Volume: |
18 |
Issue: |
4 |
Pages: |
442-455 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo W |
Year: |
2019 |
Journal: |
Nat Immunol |
Title: |
The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells. |
Volume: |
20 |
Issue: |
6 |
Pages: |
736-746 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun T |
Year: |
2002 |
Journal: |
Immunity |
Title: |
A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling. |
Volume: |
16 |
Issue: |
2 |
Pages: |
245-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dal Porto JM |
Year: |
2004 |
Journal: |
Immunity |
Title: |
Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck. |
Volume: |
21 |
Issue: |
3 |
Pages: |
443-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manno B |
Year: |
2016 |
Journal: |
Eur J Immunol |
Title: |
The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner. |
Volume: |
46 |
Issue: |
11 |
Pages: |
2520-2530 |
|
•
•
•
•
•
|
Publication |
First Author: |
Biram A |
Year: |
2019 |
Journal: |
Nat Immunol |
Title: |
BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer's patches. |
Volume: |
20 |
Issue: |
4 |
Pages: |
482-492 |
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•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Bléry M |
Year: |
2006 |
Journal: |
J Exp Med |
Title: |
Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy. |
Volume: |
203 |
Issue: |
7 |
Pages: |
1773-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enders A |
Year: |
2003 |
Journal: |
J Exp Med |
Title: |
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. |
Volume: |
198 |
Issue: |
7 |
Pages: |
1119-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iacovelli S |
Year: |
2015 |
Journal: |
Blood |
Title: |
Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL. |
Volume: |
125 |
Issue: |
10 |
Pages: |
1578-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Glassford J |
Year: |
2005 |
Journal: |
Eur J Immunol |
Title: |
Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes. |
Volume: |
35 |
Issue: |
9 |
Pages: |
2748-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo B |
Year: |
2013 |
Journal: |
Eur J Immunol |
Title: |
A novel Lyn-protein kinase Cδ/ε-protein kinase D axis is activated in B cells by signalosome-independent alternate pathway BCR signaling. |
Volume: |
43 |
Issue: |
6 |
Pages: |
1643-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rowland SL |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling. |
Volume: |
185 |
Issue: |
8 |
Pages: |
4570-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Caucheteux SM |
Year: |
2005 |
Journal: |
Int Immunol |
Title: |
Pregnancy-induced alterations of B cell maturation and survival are differentially affected by Fas and Bcl-2, independently of BcR expression. |
Volume: |
17 |
Issue: |
1 |
Pages: |
55-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Z |
Year: |
2020 |
Journal: |
Cell Immunol |
Title: |
Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells. |
Volume: |
352 |
|
Pages: |
104100 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato M |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Augmentation of signaling through BCR containing IgE but not that containing IgA due to lack of CD22-mediated signal regulation. |
Volume: |
178 |
Issue: |
5 |
Pages: |
2901-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuraoka M |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. |
Volume: |
18 |
Issue: |
7 |
Pages: |
1627-1635 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yachimovich N |
Year: |
2002 |
Journal: |
Eur J Immunol |
Title: |
The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status. |
Volume: |
32 |
Issue: |
4 |
Pages: |
1164-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Falk L |
Year: |
2014 |
Journal: |
Biol Open |
Title: |
Mutations of Cx43 that affect B cell spreading in response to BCR signaling. |
Volume: |
3 |
Issue: |
3 |
Pages: |
185-94 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Bcr/Bcr<+> |
Background: |
C57BL/6-Bcr |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferry H |
Year: |
2005 |
Journal: |
Eur J Immunol |
Title: |
Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival. |
Volume: |
35 |
Issue: |
12 |
Pages: |
3655-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
McWhirter JR |
Year: |
1993 |
Journal: |
Mol Cell Biol |
Title: |
A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. |
Volume: |
13 |
Issue: |
12 |
Pages: |
7587-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bergmann H |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A. |
Volume: |
210 |
Issue: |
1 |
Pages: |
31-40 |
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; wild type |
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; gene trap YHC044, BayGenomics |
Allele Type: |
Gene trapped |
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•
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; gene trap RRO181, BayGenomics |
Allele Type: |
Gene trapped |
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; gene trap RRR173, BayGenomics |
Allele Type: |
Gene trapped |
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•
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; gene trap RRA019, BayGenomics |
Allele Type: |
Gene trapped |
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Publication |
First Author: |
Ghosh D |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Regulation of the BCR signalosome by the class II peptide editor, H2-M, affects the development and repertoire of innate-like B cells. |
Volume: |
38 |
Issue: |
4 |
Pages: |
110200 |
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•
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•
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Publication |
First Author: |
Inui S |
Year: |
2002 |
Journal: |
Int Immunol |
Title: |
BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation. |
Volume: |
14 |
Issue: |
2 |
Pages: |
177-87 |
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Publication |
First Author: |
Castiblanco DP |
Year: |
2017 |
Journal: |
Front Immunol |
Title: |
Co-Stimulation of BCR and Toll-Like Receptor 7 Increases Somatic Hypermutation, Memory B Cell Formation, and Secondary Antibody Response to Protein Antigen. |
Volume: |
8 |
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Pages: |
1833 |
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Publication |
First Author: |
Guo B |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. |
Volume: |
178 |
Issue: |
8 |
Pages: |
4726-30 |
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Publication |
First Author: |
Volgina VV |
Year: |
2007 |
Journal: |
Mol Immunol |
Title: |
Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain. |
Volume: |
44 |
Issue: |
6 |
Pages: |
1417-28 |
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GO Term |
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GO Term |
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Genotype |
Symbol: |
Bcr/Bcr Tg(Vav1-cre)#Cgp/? |
Background: |
involves: C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Gene Segment |
Type: |
gene_segment |
Organism: |
mouse, laboratory |
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; gene trap E063C04, German Gene Trap Consortium |
Allele Type: |
Gene trapped |
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; gene trap EUCJ0019g11, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Gene trapped |
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; targeted mutation 1, Nora Heisterkamp |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; endonuclease-mediated mutation 10, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; gene trap PST13827, Mammalian Functional Genomics Centre |
Allele Type: |
Gene trapped |
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•
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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•
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Allele |
Name: |
BCR activator of RhoGEF and GTPase; targeted mutation 1, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
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•
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Genotype |
Symbol: |
Bcr/Bcr<+> Tg(CMV-cre)1Cgn/? |
Background: |
involves: BALB/c * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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•
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Publication |
First Author: |
Mizuno T |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma. |
Volume: |
174 |
Issue: |
10 |
Pages: |
6062-70 |
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•
•
•
•
•
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Genotype |
Symbol: |
Bcr/Bcr<+> Tg(Mx1-cre)1Cgn/? |
Background: |
involves: C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Genotype |
Symbol: |
Bcr/Bcr<+> Tg(Vav1-cre)#Cgp/? |
Background: |
involves: C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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