This entry represents the N-terminal region of Ge-1, also known as EDC4 (enhancer of mRNA-decapping protein 4). This WD40-repeat region is involved in protein-protein interactions [].
Ge-1, also known as EDC4 (enhancer of mRNA-decapping protein 4), is a regulator of mRNA decapping to function in the mRNA P-bodies within the cytoplasm. It has been shown to interact with mTORC1 [], coenzyme A synthase []and MARF1 []. It is also involved in the regulation of immune system [].This entry also includes EDC4 homologues from fungi and plants [].
An essential step in mRNA turnover is decapping. In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2. Dcp1 is a coactivator that binds to the decapping enzyme Dcp2 and forms a decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation []. Yeast Dcp1 interact directly with Dcp2, however, the Dcp1-Dcp2 interaction is promoted by an additional factor, EDC4 []. In the nervous system, it promotes neurons' lifespan through the negative regulation of the insulin-like peptide ins-7 expression [].
